Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"Muscle development"”.
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Comparative embryology and muscle development of polyclad flatworms (Platyhelminthes: Rhabditophora)
… an interesting and useful group for research in developmental biology. Although polyclads, together with catenulids and macrostomids, have been argued to be most closely related to the ancestral flatworm and hold the key to understand the relationship between development and evolution, knowledge …
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Methodologies to promote muscle development for engineering functional skeletal muscle tissue
The student, Eunkyung Ko, accepted the attached license on 2019-04-11 at 16:50.
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The impact of maternal immune activation on pig muscle development and postnatal immune function
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo terms
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Regulation of Cardiac Fibroblast and Coronary Vascular Smooth Muscle Development by Platelet Derived Growth Factor Receptors
Coronary vascular smooth muscle cells (cVSMC) and cardiac fibroblasts are essential for coronary artery development and are important mediators of myocardial pathogenesis. These cells form when a subset of epicardial cells undergoes an epithelial-to-mesenchymal transition (EMT) and migrates into …
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Examining the roles of resident non-myogenic mesenchymal cell populations in skeletal muscle development and injury
<p>The success of muscle development and regeneration requires cooperation from both myogenic and their supportive niche cells. The muscular niche is complex. At the cellular level it is composed of a broad number of cell types including: endothelial vessels, nerve and nerve-supporting cells, …
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Characterization of C. Elegans Pat-9 and Frg-1, Genes Critical for Body Wall Muscle Development
… human FRG1. Interestingly, in adult body wall muscle, FRG-1 associated with the cytoplasmic dense bodies whose primary function in C. elegans is to transfer mechanical force from muscle contraction to the cuticle by attaching the muscle fiber to the muscle cell membrane and the surrounding …
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The Expression of the Alpha(7)beta(1) Integrin in Skeletal Muscle Development and Muscular Dystrophy
The last two sections of this thesis will convey the importance of my work with respect to its contribution and significance to science, as well as future questions that need to be addressed.
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Characterization of C. elegans PAT-9 and FRG-1, which are critical for body wall muscle development
… cell polarity, metabolism, aging, and development. Transgenic C. elegans have been broadly utilized as a human disease model to study mechanisms of pathology for diseases such as obesity, diabetes, cancer, Duchenne’s muscular dystrophy, and several neurodegenerative diseases. In these …
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Role of SH3 and Cysteine-Rich Domain 3 (STAC3) in Skeletal Muscle Development, Postnatal Growth and Contraction
… gene is expressed specifically in skeletal muscle and essential for skeletal muscle contraction and postnatal life in mice. In this dissertation project, I conducted two studies to further understand the role of STAC3 in skeletal muscle development, growth, and contraction. In the first …
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Genomic characterization of Six1 function during skeletal muscle differentiation
… Six1 to Six6). Six1 is important for skeletal muscle development: Six1-/- mouse neonates die at birth because of severe muscle hypoplasia. However, the molecular targets of Six1 are poorly characterized systematically. The Myogenic Regulatory Factors (MRFs) are critical transcription factors in …
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Linking genome organization to nuclear function in astrocytes and muscle cells
… chromatin structures change throughout mammalian development remains to be determined. I have mapped genome-wide chromatin interactions in mouse muscle progenitor cells (myoblasts) and in terminally differentiated muscle cells (myotubes) using HiC, in order to uncover chromatin reorganization …
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FROM MUSCLE TO MEAT: MORPHO-FUNCTIONAL FOUNDATIONS FOR APPLICATIVE ASPECTS.
The transformation of muscle into meat is a biologically complex mechanism with deep implications for animal physiology, the meat industry, and food science. Understanding the morpho-functional foundations of this process -including structural, cellular, and molecular characteristics of muscle …
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Defining the Role of Pannexin1 in Skeletal Muscle and Satellite Cell Function in vivo and ex vivo Using a Novel Conditional Knockout Mouse Model
… a key role in myogenesis. However, its role in muscle development remains to be elucidated. Using a novel skeletal-muscle-specific Panx1 knockout (Panx1^smKO) mouse model, this thesis highlights the influences Panx1 plays in muscular development and maintenance, as well as in muscle function. …
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Investigating the molecular function of Akirin during skeletal myogenesis in Drosophila melanogaster
<p>The specification and differentiation of muscle precursor cells, or myoblasts, by the action of the mesodermal and muscle transcription regulator Twist is a key event in the formation of the <em>Drosophila </em>larval musculature. Akirin, a highly conserved nuclear protein, appears to play a …
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Effect of mechanical stretching on the maturation of 3-D fascicle-like muscle tissue
Skeletal muscle is well known for a rapid adaptation to mechanical environmental changes. Understanding the effects of the mechanical stimulation such as stretching to muscle tissues is important for understanding the nature of muscle development and muscle diseases. While there are many reports …
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The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
… related to physiological activities and the development of diseases. Emerging evidence has shown that PGE2 plays an important role in regulating the survival and proliferation of hematopoietic stem cells, suggesting that PGE₂ signaling could be essential for tissue development and …
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Roles of Myocardin-Related Transcription Factors in Muscle and Brain
… cofactors govern gene transcription in various developmental and tissue contexts, particularly during cardiovascular and neuronal development. This dissertation aims at studying the in vivo relevance of the partnership between Serum response Factor (SRF) and its Myocardin Related Transcription …
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