Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Muscle degeneration"”.
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Selective Muscle Degeneration in a Drosophila Model of Cachexia; A Role for the Transcriptional Regulator cabut
… metabolic syndrome characterized by progressive muscle wasting. Cachectic muscle wasting presents as a comorbidity with pathological illnesses like cancer, chronic inflammation, and type 2 diabetes. The development of cachexia complicates treatment of these diseases and worsens clinical outcomes. …
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Synthesis of Protected Amino Alcohols and Amino Aldehydes.
Muscle degeneration and wasting in muscular dystrophy (MD) has been shown to be associated with high levels of proteolytic enzymes called Cathepsins. Antipain and leupeptin, naturally occurring peptide aldehydes, have been shown to be of possible therapeutic value in treatment of MD. The cost of …
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Mitochondrial Biology in Sporadic Inclusion Body Myositis
… Body Myositis (sIBM) is an inflammatory muscle disease that strikes individuals at random and accounts for approximately 1/3 of all idiopathic inflammatory myopathies. It is characterized by progressive weakness of distal and proximal muscles and is the most common muscle disorder in …
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AGE-RELATED GUT DYSBIOSIS ACCELERATES THYMIC INVOLUTION AND ALTERS PERIPHERAL T CELL REPERTOIRE IN DUCHENNE MUSCULAR DYSTROPHY
… interplay between the immune system and skeletal muscle, particularly in the context of inflammatory muscle disorders and dystrophic conditions like Duchenne Muscular Dystrophy (DMD), as well as during the natural process of muscle regeneration. Conventionally, immune system activation was …
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Dissecting the signaling and mechanical functions of the dystrophin-glycoprotein complex in skeletal muscle
… disorder characterized by severe and progressive muscle degeneration, which is caused by mutations in the gene encoding the dystrophin protein. Dystrophin is required for assembly of the dystrophin-glycoprotein complex (DGC) and provides a mechanically strong link between the cytoskeleton and the …
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Cardiorespiratory abnormalities in early and advances stage mouse models of Duchenne muscular dystrophy
… muscular dystrophy (DMD) is an X-linked severe muscle disease caused by dystrophin gene mutations affecting 1 in 3,500 newborn males worldwide every year. DMD is characterized by progressive skeletal muscle degeneration and weakness. In advanced disease, respiratory insufficiency and dilated …
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Sphingolipids Modulate the Inflammatory and Functional Response in mdx Mice
… Dystrophy (DMD) is characterized by progressive muscle degeneration and a chronic inflammatory response. Sphingolipid metabolites are associated with the generation or perpetuation of low-grade chronic inflammation critical in atherosclerosis, obesity and cancer. Dietary sphingolipids, however, …
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An Alpha7beta1 Integrin-Based Treatment of Muscular Dystrophy
Efficient muscle function depends on the attachment of myofibers to their surrounding basement membranes. Two complexes that mediate such interactions in adult skeletal muscles are the alpha7beta1 integrin complex and the dystrophin protein complex. Both act as molecular chains that connect the …
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Proteomic Characterisation of the mdx-4cv mouse model of Duchenne Muscular Dystrophy
… as a stabilising support network during normal muscle excitation-contraction-relaxation cycles. In Duchenne muscular dystrophy, the loss of dystrophin and its associated protein complex leads to membrane instability and micro-rupturing, the influx of excessive levels of calcium ions, the …
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Variable stiffness orthosis for gait normalization in patients with toe walking
… neuro-muscular disorder that causes progressive muscle degeneration. DMD patients tend to walk on their tip toes because of their weak calf muscles and currently do not have many options for managing the fatigue induced by supporting most of the foot strike impact with the ball of their feet. …
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Evaluating the effects of acoustic stimulation on fibroblast cell migration and muscle fibre formation.
… mechanical stimulation be used to encourage muscle cell growth? The data generated in this thesis will be completely new knowledge which will help us develop our understanding of mechanotransduction and help us develop new approaches and devices to address medical challenges such as …
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Cellular and molecular regulation of skeletal muscle regeneration
<p>Skeletal muscle regeneration provides a powerful model to study the cellular and molecular mechanism governing stem cell function since the whole process is mediated by a population of muscle-resident stem cells called satellite cells. The overall aim of this dissertation is to explore the roles …
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Green tea extract and epigallocatechin gallate decrease muscle pathology and NF-κB immunostaining in regenerating muscle fibers of mdx mice
… genetic disorder characterized by severe muscle wasting and early death in affected boys. The primary cause of this disease is mutations in the dystrophin gene resulting in the loss of the dystrophin protein from the plasma membrane of muscle fibers. In the absence of dystrophin, muscles …
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IMPACT OF DRP1 ACTIVATION, UNFOLDED PROTEIN RESPONSE INDUCTION AND FGF21 LEVELS IN DMD PROGRESSION
… dystrophy (DMD) is a severe genetic progressive muscle-wasting disease. The transmission of this pathology is X-linked recessive with an incidence of at least 1:5000 newborn boys. Patients typically present the first symptoms related to motor impairments very early in childhood and if not …
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CORRECTION OF THE GENETIC DEFECT IN INDUCED PLURIPOTENT STEM CELL LINES THROUGH CHROMOSOME TRANSPLANTATION
… is expressed primarily in skeletal and cardiac muscles, where is part of the dystrophin-associated protein complex (DAPC) or dystrophin glycoprotein complex (DGC) and plays a structural role by linking the cytoskeleton to the extracellular matrix (ECM) to maintain the sarcolemma integrity. …
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A Neuromuscular Look Into Genetics of Muscle Aging
… age throughout their life, they experience muscle tissue loss that impacts their quality of life such as a decrease in their physical capabilities and sometimes even their mental capacity. The process of muscle aging is the key point of this study. This involves the individual’s muscles and …