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Showing 1 to 20 of 172 for “"Muscle contraction"”.
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Modeling vascular smooth muscle contraction
… to investigate issues regarding vascular smooth muscle contraction. The overall structure of this thesis consists of (1) a model of single vascular smooth muscle cell membrane electrophysiology, contractile system kinetics and cell mechanics; (2) a model of signal transduction of nitric-oxide …
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A control model of muscle contraction
… that are currently thought to cause a muscular contraction. The model is developed with the hypothesis that a series of disturbing signals (or inputs) simply propagate faster than the respective controlling signals can correct for them. Transfer functions for each system are developed, with …
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Regulation of smooth muscle contraction by protein phosphorylation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Comparison of Receptor Efficacies on Vascular Smooth Muscle Contraction
<p>Vascular smooth muscle contraction involves multiple signal-transduction pathways, the interrelations of which are not completely understood. Our objectives in this project were to compare the effects of phenylephrine (alpha<sub>1</sub>-adrenergic agonist, angiotensin II (AT<sub>1 …
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Developmental regulation of smooth muscle contraction in the urinary bladder
Smooth muscle cells in the urinary bladder are involved in the control of urine filling and emptying. We have used mice to study the contractile regulation of urinary bladder smooth muscle during the fetal period. We found that nerve-induced contractions are mainly dependent on muscarinic receptor …
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Closed Loop Control of Muscle Contraction using Functional Electrical Stimulation
… Stimulation works by stimulating the atrophied muscle or group of muscles directly by current when the transmission lines between the central nervous system are disrupted. This technique helps maintain muscle mass and promote blood flow in the absence of a functioning nervous system. The goal of …
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Mechanism of Action of Pentobarbital Induced Attenuation of Vascular Smooth Muscle Contraction
… (10 Hz, 0.3 ms, 50 V, 30 sec), and direct smooth muscle (MEFS) stimulation in the presence of TTX (10 Hz, 3 ms, 50 V, 30 sec). Rings, preloaded at 1 g, were immersed in an organ bath filled with Krebs solution at 37°C, and aerated with 95% 02:5% CO<sub>2</sub>. PB (1 mM) attenuated only the tonic …
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Disrupting dynamic f-actin enhances skeletal muscle contraction due to mechanical softening
Skeletal muscle wasting disorders such as sarcopenia affect the daily mobility of millions of aging people globally due to decreased muscle mass and decreased muscle efficiency. In this study we discover a novel target to improve the efficiency of skeletal muscle by targeting the dynamic f-actin …
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A Kinetic Investigation of the Mechanism of Muscle Contraction with a Series of Nucleotides
<p>Muscle contraction is thought to be accomplished by sliding of myosin filaments along actin filaments. Although actomyosin naturally uses ATP as an energy source, it can also use other nucleoside triphosphates (NTP) as substrates. In this work, the dependence of rate and equilibrium constants of …
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The Pedunculopontine Nucleus: A Potential Site of Respiratory Modulation During Muscle Contraction and Hypoxia
… respiratory adjustments that accompany skeletal muscle contraction in anesthetized rats. Extracellular single-unit electrophysiologic recordings were employed in the first group of studies to demonstrate that individual PPN neurons exhibited increases in firing rate during activation of muscle …
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The Effect of Isotonic and Isometric Muscle Contraction Training on Speed, Force, and Strength
Made available in DSpace on 2014-12-04T21:57:14Z (GMT). No. of bitstreams: 1 5902038.pdf: 5905753 bytes, checksum: e735154eb814b21e8266e548854a0af5 (MD5) Previous issue date: 1959
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Characterisation of dynamics associated with skeletal muscle contraction initiated by Acetylcholine injection Ghabiba Modak.
… in flaccid paralysis in which the affected muscles are unable to be stimulated artificially via the supplying nerve. Such damage is common in patients who suffer from spinal cord injury and Multiple Sclerosis. Current practice for artificial recovery of muscle function involves stimulating …
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An Investigation of Three Behavioral Approaches Used in the Treatment of Chronic Muscle Contraction Headaches
… and Systematic Desensitization) of treating muscle contraction headache pain in individual chronic headache patients. Procedure. Nine chronic muscle contraction headache patients were treated with behavioral methods as an adjunct to regular medical treatment at the Mercy Hospital Pain Center. …
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The investigation of phase synchronization in the cortex during a fatiguing muscle contraction using EEG
Includes bibliographical references (leaves 140-157).
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Pyruvate dehydrogenase activity in response to skeletal muscle contraction at two stimulation frequencies in pyruvate dehydrogenase kinase 2 knockout mice
… in regulating carbohydrate oxidation in skeletal muscle. PD H is deactivated by a set of PD H kinases (PD K 1-4) with PDK2 and 4 being the predominant isoforms in skeletal muscle. PDK2 is highly sensitive to pyruvate inhibition, and is the most abundant isoform, while PDKI and 4 protein content …
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Stretch-Shortening Cycle in Human Muscle Contraction: The Role of the Stretch Reflex in Force Production in Various Vertical Jumps
… the stretch reflex and the elasticity of the muscle contribute to the effectiveness and efficiency of human performances, the relative contributions of each have not been determined, because no direct measurements have been utilized. Therefore, the purpose of this study was to investigate the …
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Interactions of Smooth Muscle Myosin Filaments with Actin and Myosin Light Chain Kinase: Insights into the Mechanics of Smooth Muscle Contraction
The functional form of smooth muscle myosin (SMM) within cells is the filament. Smooth muscle contraction is thick (myosin) filament-regulated by phosphorylation of the myosin regulatory light chain (RLC). Upon phosphorylation of Serine 19 of the RLC of SMM by myosin light chain kinase (MLCK), SMM …
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Collective Force Generator Model of Muscle Contraction: Theoretical and Experimental Support for Factors Beyond Detachment Kinetics that Influence Unloaded Shortening Velocities of Muscle
… of how single molecule properties of muscle myosin collectively generate unloaded shortening velocities, V. Theory, experimentation, and simulation results all contributed to answering fundamental muscle research questions. These questions focused on addressing how single myosin …
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