Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 409 for “"Muscle cells."”.
-
Direct Reprogramming of Fibroblasts into Smooth Muscle Cells
The generation of induced pluripotent stem (iPS) cells is a useful tool for regenerative medicine. However, the risk of tumor development of the aforementioned cells should be addressed before they can be used for clinical applications. During the reprogramming process a number of signal pathways …
-
Roles of Zinc in Skeletal Muscle Cells Growth
Zinc deficiency impairs skeletal muscle growth in both humans and animals independently of decreased food intake. Insulin-like growth factor (IGF) is the primary regulator of postnatal muscle growth and there is substantial evidence that the effects of zinc deficiency alter IGF mediated muscle …
-
Dedifferentiation of muscle cells during Trichinella spiralis infection
… Trichinella spiralis invades host skeletal muscle cells and reside intracellularly. The host cell is dedifferentiated, losing its muscular specialisation, and re-entering the cell cycle transiently. Over a period of around 20 days post-invasion the host cell is converted into a “nurse cell” …
-
Tensile Properties of Single Vaginal Smooth Muscle Cells
… In this study, we tested single vaginal smooth muscle cells (SMCs) to quantify their elastic moduli. Cells were enzymatically isolated from vaginal walls of freshly sacrificed, virgin Long Evans rats and cultured using well-established methods. A custom-built experimental setup was used to …
-
Epigenetic Modification of Phenotype in Intestinal Smooth Muscle Cells
… causes proliferation of intestinal smooth muscle cells (ISMC), contributing to the thickened intestinal wall and the dysmotility symptoms observed in inflammatory bowel disease (IBD). A unique consequence of Crohn’s disease (CD), a subset of IBD characterized by chronic, transmural …
-
Cytokine-Induced Igf-I Resistance in Progenitor Muscle Cells
… promotes growth and regeneration of skeletal muscle. Conversely, elevated levels of proinflammatory cytokines are associated with reduced anabolic activity of IGF-I and increased loss of muscle mass that occurs during aging and more prominently in cachectic AIDS and cancer patients. The loss …
-
Effects of heparinoids on bovine aortic smooth muscle cells
Smooth muscle cells (SMCs) comprise the bulk of the tunica media of all blood vessels. Upon injury to the overlying endothelial monolayer of blood vessels, SMCs proliferate into the lumen of the vessel and cause dangerous occlusions. The glycosaminoglycan (GAG) heparin has been shown to be …
-
Mitochondrial function in atherosclerosis and vascular smooth muscle cells
… function in atherosclerosis and vascular smooth muscle cells Johannes Reinhold Atherosclerosis is the leading cause of death in the Western world. Although mitochondrial DNA (mtDNA) damage has been implicated in atherosclerosis, it is unclear whether the damage is sufficient to impair …
-
Pathways of intracellular protein degradation in cultured muscle cells
… responsible for the turnover of endogenous muscle protein, lysosomotropic proteinase inhibitors have been employed to elucidate the relative contributions of lysosomal and non-lysosomal degradation pathways functioning under varying nutritional states and for different classes of …
-
The instructive roles of muscle cells in planarian regeneration
… maintain tissue homeostasis. Dividing cells, neoblasts, are the source of all new tissue, whereas positional information is hypothesized to be harbored by post-mitotic muscle, including the subepidermal body wall musculature. Single-muscle-cell mRNA sequencing along the …
-
Biosynthesis and degradation of proteoglycans in cultured smooth muscle cells
Smooth muscle cells isolated from neonatal rat hearts synthesize and secrete radioactively labelled proteoglycans into two distinct extracellular compartments, the pericellular (cell surface/matrix layer) and the culture medium (extracellular). Cultures grown in the presence of ascorbic acid …
-
The effects of linoleate on insulin action in skeletal muscle cells
… insulin resistance in L6 rat skeletal muscle cells, the inhibition of IRS-1-dependent signalling arises via effects on both the phosphorylation status and degradation of IRS-1, which are mediated, in part, by IKKb. In addition, the reduction of IRS-1 mRNA levels allude to …
-
Characterizing the Mechanisms Regulating Enhancer Commissioning by MyoD in Muscle Cells
… refers to the cellular process required for muscle formation and repair of damaged muscle tissue. During this process, the activation of muscle gene expression is tightly regulated to ensure efficient transitions between cell fates. This activation is promoted by large groups of neighbouring …
-
Effects of naringenin on glucose uptake in L6 skeletal muscle cells
… in the classic target tissues (adipose, muscle, liver), as well as defects in a-cells and kidney, brain, and gastrointestinal tissue. Present oral treatments, which aim at mimicking the effects of insulin, remain limited in their efficacy and therefore the study of the effects of novel …
-
Linking genome organization to nuclear function in astrocytes and muscle cells
… genome-wide chromatin interactions in mouse muscle progenitor cells (myoblasts) and in terminally differentiated muscle cells (myotubes) using HiC, in order to uncover chromatin reorganization patterns during muscle development. I observe extensive switches between A and B compartments during …
Page 1 of 21