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Showing 1 to 12 of 12 for “"Muscle biology"”.
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Discovery of New Regulatory Proteins and Mechanisms in Muscle Biology and Disease
In an effort to discover new regulators of muscle function, we identified a novel muscle-specific protein, Klhl40. Genetic deletion of Klhl40 in mice results in a nemaline myopathy-like phenotype with disruption of sarcomere function causing neonatal lethality. Nemaline myopathy (NM) typically …
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Effects of Extrinsic and Intrinsic Factors on Meat Quality and Muscle Biology of Livestock
… most common factors to improve meat quality and muscle growth. The objective of this thesis is to perform a horizontal comparison of the effects of crude protein levels, breeds, and topsoil on the growth performance, muscle development, and meat quality of livestock, and also a longitudinal …
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FROM MUSCLE TO MEAT: MORPHO-FUNCTIONAL FOUNDATIONS FOR APPLICATIVE ASPECTS.
The transformation of muscle into meat is a biologically complex mechanism with deep implications for animal physiology, the meat industry, and food science. Understanding the morpho-functional foundations of this process -including structural, cellular, and molecular characteristics of muscle …
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Myogenic Effectors and Disease
Skeletal muscle is essential for life. Inside muscle fibers, filaments of actin and myosin slide on each other to generate the mechanical forces that drive muscle contraction, movement, and breathing. Mutations in muscle-related genes can cause severe diseases in humans. Here we characterize the …
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A High-Throughput Approach to Uncover Novel Roles of APOBEC2, a Functional Orphan of the AID/APOBEC Family
… diverse organisms and cellular processes such as muscle biology (in Mus musculus), regeneration (in Danio rerio), and development (in Xenopus laevis). APOBEC2 has also been implicated in cancer. However the enzymatic activity, substrate or physiological target(s) of APOBEC2 are unknown. For this …
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THE ROLE OF INNERVATION IN ENGINEERED MUSCLE
Skeletal muscle injuries span a wide spectrum, from minor strains to devastating traumatic events, and represent a significant clinical challenge worldwide. Millions of individuals experience severe muscle deficits each year, including volumetric muscle loss (VML) resulting from ballistic trauma, …
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Diet, inflammation and skeletal muscle mass in women
… Sarcopenia is the progressive decline of muscle mass, strength and function that occurs with healthy ageing. The ageing process is also associated with a gradual increasing production of pro-inflammatory cytokines, which may potentially enhance the development of sarcopenia. Dietary …
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Postmortem energy metabolisms' role in calpain activation, inhibition, and subsequent function
… Among the various proteolytic systems active in muscle after exsanguination, the calpain system, particularly calpain-1, is considered central to the tenderization process. However, the specific biochemical conditions that govern calpain-1 activation and its ability to degrade myofibrillar …
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EFFECTS OF HISTONE DEACETYLASE INHIBITORS ON ENERGY METABOLISM
… between the insulin responsiveness of skeletal muscle, liver, adipose tissue and glucose-stimulated insulin secretion by pancreatic beta cells. Defects in these organs are responsible for insulin resistance and progression to hyperglycemia. Understanding the integrated pathophysiology initiating …
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3D Human Skeletal Muscle Model for Studying Satellite Cell Quiescence and Pompe disease
<p>Tissue-engineered skeletal muscle presents promising opportunities for developing high-fidelity in vitro models for investigating human muscle biology in the areas of regeneration and disease. In muscle regeneration, satellite cells (SCs) are essential for new muscle fiber formation; however, …
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The Role of BiP Co-chaperone SIL1 in Marinesco-Sjögren Syndrome Pathogenesis
… affected multiple pathways critical to muscle physiology. We observed an increase in ER chaperones prior to the onset of muscle weakness, which was complemented by up-regulation of multiple protein degradation pathways. These responses were inadequate to maintain normal expression of …