Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 90 for “"Muscle Weakness"”.
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Skeletal muscle weakness and mitochondrial dysfunction in the osteogenesis imperfecta murine (oim) model
… the most prominent manifestation of OI, skeletal muscle weakness, cardiopulmonary complications, short stature, and craniofacial abnormalities are also common. There is currently no cure for OI and therapeutic options rely on mitigating symptoms, primarily through the use of bone anti-resorptive …
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Neuromuscular electrical stimulation to improve muscle weakness in hip osteoarthritis: A feasibility study
… of neuromuscular activation required to induce a muscle strength adaption before and after surgery and therefore innovations are required. Neuromuscular electrical stimulation (NMES) is the elicitation of muscle contraction using electric impulses that can restore and increase skeletal muscle mass …
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The effect of inspiratory muscle training on clinical outcomes and health-related quality of life in children with neuromuscular disease and respiratory muscle weakness.
Background: Progressive respiratory muscle weakness and ineffective cough contributes to pulmonary morbidity and mortality in children with neuromuscular disease. Inspiratory muscle training aims to preserve or improve respiratory muscle strength, reduce respiratory complications and improve …
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Skeletal Muscle Function, Morphology, and Biochemistry in Ts65Dn Mice: A Model of Down Syndrome
… stages is hypotonia and generalized muscle weakness. The cause of muscle weakness in Down syndrome is not known and there is an immediate need to establish an acceptable animal model to explore the muscle dysfunction that is widely reported in the human population. Using a combination …
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Factors limiting the exercise tolerance of patients with end-stage renal failure undergoing maintenance haemodialysis
… others suggest that peripheral (skeletal muscle) limitations including impaired substrate utilization, muscle weakness caused by peripheral neuropathy and myopathy, malnutrition and general physical deconditioning are responsible for the poor exercise tolerance. The present thesis was …
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Parallels and Divergences in Multisystem Proteinopathy Genes: Stress Granules, Autophagy, and Myogenic Deficits
… modifier with SQSTM1P392L leading to distal muscle weakness rather than proximal muscle weakness seen with monogenic SQSTM1 mutations. Here we show that the same TIA1 variant is able to act as a modifier with VCP R159H to produce the same distal weakness. We established three major findings: …
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Vliv funkční elektrické stimulace na svalovou sílu kriticky nemocných
Introduction: Muscle weakness is a manifestation of multi-organ dysfunction at peripheral nerve and muscle level, and its severity is that it prolongs weaning and reduces rehabilitation options in critically ill patient. New approaches to the treatment of critically ill patient lie primarily in …
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A novel compound heterozygous NEB mutationin Korean patients with intellectual disability, epilepsy,and acongenital myopathy
… intellectualdisability,epilepsy,and generalized muscle weakness of early childhood onset. I performed several conventional genetic tests to detect chromosomal aberrations, gene copy number variations, and candidate gene and mitochondrial gene mutations. After finding no abnormality ,I conducted …
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Muscle Activation During High and Low Intensity Strength Training In Older Adults With Knee Osteoarthritis
Introduction: Muscle weakness is a common impairment in the knee osteoarthritis (OA) population that is partially due to an impairment in the central nervous systems ability to activate a muscle fully. The effect of resistance training intensities on muscle activation in the knee OA population has …
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Acute hypoxia-induced diaphragm dysfunction is prevented by antioxidant pre-treatment
Diaphragm weakness is a strong predictor of poor outcome in patients. Acute hypoxia is a feature of respiratory conditions such as acute respiratory distress syndrome and ventilator-associated lung injury. However, the effects of acute hypoxia on the diaphragm are largely unknown despite the …
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Neuropsychiatric symptoms in thymoma-associated and non-thymoma myasthenia gravis
… neuromuscular junction resulting in fatigable muscle weakness. A number of reports have suggested a high prevalence of psychiatric symptoms amongst MG patients. Approximately 10% of MG subjects are found to have an associated thymoma and despite thymomectomy, the MG persists. The presence of …
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Microtubule Regulation of Mitochondrial Bioenergetics in Cardiac and Skeletal Muscles
… key mitochondrial functions that are critical to muscle cells. VDAC is also believed to be central to the formation of the mitochondrial permeability transition pore (mPTP) which releases pro-apoptotic factors that trigger cell death. To date, a direct measure of a tubulin-VDAC interaction has yet …
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ANALYSIS OF AXONAL TRANSPORT DEFECTS IN A ZEBRAFISH MODEL FOR SPINAL MUSCULAR ATROPHY
… loss of α-motor neurons (MNs), leading to muscle weakness, atrophy, and in the worst cases death. SMN is a ubiquitously expressed protein that is involved in spliceosome assembly. A decrease in SMN protein levels leads to the dysregulation of splicing of downstream genes and thereby impairs …
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Muscle Strength, Motor Units, and Aging
Introduction: The interrelationship between muscle strength, motor units, and aging is not well known. Methods: This investigation utilized the motor unit number index technique (MUNIX) to elucidate this relationship. Beforehand, an experiment was conducted to assess the absolute and relative …
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THE ASSESSMENT AND DEVELOPMENT OF FOLLISTATIN AS A GENE THERAPY AND ITS POTENTIAL ORTHOPEDIC APPLICATIONS
… of inherited disorders that are characterized by muscle weakness and loss of muscle tissue with the symptoms generally worsening over time. Most therapies that have been invented and researched until now have aimed at targeting dystrophin which is the gene that is defective in muscular dystrophy …
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The ALS Genes TDP-43 and FUS/TLS Regulate a Common Pathway in the Nervous System of Drosophila Melanogaster
… with this condition commonly experiences muscle weakness that progresses to generalized paralysis. Although most ALS cases are sporadic, mutations in several human genes of divergent molecular function have been linked to the development of ALS. Recently, two new ALS genes, TDP-43 and FUS, …
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Analysis of The Demographics, Pathways to Diagnosis, Burden of Disease and Long-term Outcomes of Patients with Spinal Muscular Atrophy Managed at Red Cross War Memorial Children's Hospital
… cell degeneration which results in symmetrical muscle weakness that affects multiple systems. This study was conducted to determine the burden of disease of SMA on children under the neuromuscular service at Red Cross War Memorial Children's Hospital. A quantitative retrospective audit …
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Admittance control of the intelligent assist robot manipulator for people with duchenne muscular dystrophy
… 1 in 3500 male births, results in characteristic muscle weakness which is progressive with age and leads to loss of independence. And, in this population, maintaining optimal quality of life depends on the preservation of self-sufficiency. Despite the loss of function, non-ambulant people with DMD …
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MACROPHAGE RESPONSE TO INITIAL MUSCLE DENERVATION IN THE SOD1-G93A MOUSE MODEL OF AMYTROPHIC LATERAL SCLEROSIS.
… and lower MNs. Loss of the connections of MN to muscle at the neuromuscular junction (NMJ) underlies the characteristic muscle weakness seen in ALS. NMJs from fast-fatigable (FF) MNs preferentially denervate early in the disease process compared to fast-fatigue resistant (FR) and slow (S) NMJs. …
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Predictors of Knee Extensor Strength in Patients with Chronic Obstructive Pulmonary Disease
Skeletal muscle weakness of the lower extremities is frequently observed in chronic obstructive pulmonary disease (COPD) patients when compared to healthy age matched controls. PURPOSE: To determine predictors of knee extensor strength in COPD patients. METHODS: Knee extensor strength was measured …
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