Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Muscle Repair"”.
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Perivascular cell contribution to skeletal muscle repair following physiological injury
PURPOSE: We have previously demonstrated that muscle-derived mesenchymal stem cells (MSCs; Sca-1+CD45-) accelerate Pax7+ satellite cell expansion and fiber repair during the initial stages of eccentric exercise training in mice. MSCs are a heterogeneous population of perivascular stromal cells, …
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Development of novel strategies to improve skeletal muscle repair and adaptation following eccentric exercise
… as well as daily activities, can injure skeletal muscle. The repair of muscle damage is essential for effective remodeling, tissue maintenance, and initiation of beneficial adaptations post-exercise. We have previously demonstrated that transgenic overexpression of the α7BX2 integrin in skeletal …
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DEVELOPMENT OF A TISSUE ENGINEERED SKELETAL MUSCLE REPAIR CONSTRUCT FEATURING BIOMIMETIC PHYSICAL, CHEMICAL, AND MECHANICAL CUES
Volumetric muscle loss (VML) injuries are particularly debilitating, and commonly result from trauma, infection, congenital defect, or surgical side effect. Unfortunately, current medical treatments for these injuries are lacking. The "gold standard" for treatment of critical-size defects remains …
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Naturally Derived Scaffolds for Treatment of Volumetric Muscle Loss
Volumetric muscle loss (VML) is defined as the irrecoverable loss of function in skeletal muscle as a result of tissue loss. Herein, cell and growth factor loaded keratin hydrogels and Tissue Engineered Muscle Repair (TEMR) constructs consisting of cell seeded, cyclic stretched bladder acellular …
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T cell mediated satellite cell function: implications for age-associated changes in skeletal muscle regeneration
Sarcopenia is an age-associated loss of skeletal muscle mass and strength. Recent evidence suggests that an age-associated loss of muscle precursor cell (MPC) functionality contributes to sarcopenia. Current research also suggests that T cells of the immune system may influence skeletal muscle …
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Post-Translational Modifications of the Paired Box Transcription Factor 7 (Pax7) in Satellite Cells During the Repair of Injured Skeletal Muscle
Satellite cells are normally a quiescent skeletal muscle stem cell pool that upon activation rapidly proliferate and differentiate to repair damaged muscle fibers. The paired box transcription factor 7 (Pax7) is the canonical biomarker for quiescent, activated, and proliferating satellite cells and …
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The effects of tributyrin and butyrate on equine skeletal muscle
… for supplements that can improve performance and muscle recovery. Tributyrin and butyrate affect satellite cells and oxidative metabolism in other species. To assess the effects of tributyrin on equine muscle repair, Thoroughbred horses were supplemented tributyrin, and a submaximal exercise test …
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Skeletal muscle pericyte response to acute and chronic electrical stimulation
… studies suggest that pericytes in skeletal muscle may contribute to myofiber repair in response to injury. However, the pericyte response to exercise remains largely unexplored. PURPOSE: The purpose of this study was to evaluate pericyte quantity and gene expression in skeletal muscle …
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The effects of water immersion on recovery in Australian football
… as well as increases in psychometric measures, muscle damage and inflammation. The use of both cold water immersion (CWI) and contrast water therapy (CWT) as a means of post-exercise recovery is becoming more prevalent in the team sport environment. Both modalities are utilised in an attempt to …
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Regulatory Immune Responses and Repair Mechanisms in Atherosclerosis
… atherosclerosis-related antigens and smooth muscle repair responses play important roles. This thesis contains studies focusing on both regulatory immune responses and tissue repair mechanisms in experimental models of atherosclerosis as well as in patient cohorts. The first part of this …
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The Physiological and Genetic Factors Underpinning the Response to Muscle Damaging Exercise
… variability in the response to exercise-induced muscle damage (EIMD), even when tested in a homogeneous cohort accounting for age, sex, ethnicity and physical activity. The response to EIMD is very complex as several tissues, including skeletal muscle fibres, the extra-cellular matrix (ECM), and …
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Impact of Leucine and HMB on Acute Muscle Damage: Focus on Repair and Regeneration in vivo and in vitro
Introduction: Skeletal muscle is an amalgamation of multiple terminally differentiated myofibers which are capable of regeneration after injury. The satellite cell is the driving factor for muscle regeneration, influenced by their internal and external environment. The majority of these processes …
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The Relationships of Age, Physical Activity Level, Adiposity, and Diet, with Human Satellite Myogenesis, and Metabolism
… satellite cells are partly responsible for muscle repair and preventing atrophy. Previous studies have linked the loss of muscle mass associated with aging to satellite cell dysfunction, postulating that satellite cell function diminishes with age. New evidence suggests that this may not be …
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Behaviour of human myoblasts in vitro: role of ageing and inflammatory cytokines
Ageing is associated with a loss of muscle mass, a processes known as “sarcopenia”. It has been postulated that one of the reasons underlying this muscle loss is a decreased ability to repair itself in response to damage. Repair of muscle is facilitated by a specific population of progenitor adult …
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Investigating the use of omega three fish oils as protective agents against cytokine-induced skeletal muscle damage
IntroductionMuscle injury and disease impacts on the lives of adults and children, contributing tosevere morbidity and increased mortality e.g. Muscular dystrophy affects over 70,000people UK wide (Muscular Dystrophy UK). Treatment of muscle disorders contributeto unemployment rates and cost the …
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Treatment-resistant ophthalmoplegia in Myasthenia gravis: extraocular muscle pathology, the role of TGFβ1 and the derivation of induced pluripotency towards 'disease-in-a-dish' modeling
… of patients has antibodies directed against muscle-specific tyrosine kinase (MuSK). In MG the pathogenic antibodies result in failure of neuromuscular transmission with consequent fatiguable skeletal muscle weakness. MG frequently affects the extraocular muscles (EOMs) early in the course of …
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Evidence-based design, physiological efficacy testing and consumer analysis of an exemplar model of a fruit derived bioactive functional food for use in physical performance and exercise settings
… particularly in the form of bovine milk, for muscle repair and regeneration post-exercise. RCTs have consistently shown the benefits of consuming between 1.2-1.6g/kg/day of high-quality protein for those undergoing frequent exercise. While there's growing evidence to support the use of …
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Investigation of plant protein functionality for food applications and health benefits
… versus animal protein (whey and egg white) on muscle repair, recovery, and performance following intense exercise. A 12-week randomized controlled trial with 24 participants (18-35 years) included resistance training and protein supplementation. Muscle function and recovery were assessed using …
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Effects of pulsed electromagnetic field therapy on symptoms associated with eccentric exercise-induced muscle damage
… consisting of eccentric contractions induces muscle damage that is characterised by muscle weakness, soreness, swelling and increased muscle stiffness. These symptoms affect daily activities and athletic performance; therefore, interventions to attenuate the symptoms and enhance recovery from …