Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Muscle Physiology"”.
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Nitric oxide influences muscle physiology and meat quality
… to have high levels of activity in skeletal muscle and the activity of the neuronal isoform of NOS was higher in muscle than in the brain. Roles for NO in the regulation of muscle contractility, energy metabolism, calcium homeostasis, and proteolysis have emerged. Since many of these …
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The Role of Two Homologous E3 Ligases In Muscle Physiology
… z-disc protein expressed in cardiac and skeletal muscle that is critical to proper structure and function of muscles. Through preliminary experiments, we identified TCAP as a novel shared target substrate of FBXL3 and FBXL21. Here we report that FBXL3 and FBXL21 both accelerate TCAP degradation; …
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NOVEL ROLES FOR GRK2 IN METABOLIC HOMEOSTASIS AND SKELETAL MUSCLE PHYSIOLOGY
… protein-coupled receptor kinase 2 (GRK2) in the physiology and pathophysiology of the heart. Adrenergic receptors are the primary target for GRK2 activity in the heart; phosphorylation by GRK2 leads to desensitization of these receptors. As such, levels of GRK2 activity in the heart directly …
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Understanding adaptive regulation of skeletal muscle physiology in the Weddell seal: a proteomics approach
… adults. Proteins from the primary swimming muscle (M. longissimus dorsi) of two distinct age classes, pups (3-5 weeks/nondivers) and adults (7+ years/expert divers), were visualized using two dimensional gel electrophoresis (2DE), quantified, and identified. This study validated the use of …
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The development of an in vivo nerve-muscle model in the rat : and an experiment "The interaction between rocuronium and thiopentone" to test the validity of the model
… of our current understanding of nerve - muscle physiology. This dissertation describes the development of an in vivo model of the rat nerve interface at the Faculty of Health Sciences at the University of Cape Town. Such a model was not previously available to the faculty. The development …
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Aerobic Exercise-Mediated Prevention Against Glucocorticoid Myopathy in Aged Skeletal Muscle
… adults are vulnerable to glucocorticoid-induced muscle atrophy and weakness, with sex potentially influencing susceptibility to those effects. Aerobic exercise can reduce glucocorticoid-induced muscle atrophy in young rodents. However, it is unknown whether aerobic exercise can antagonize …
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Transcriptomic Signatures of Skeletal Muscle Adaptation: Disuse, Rehabilitation, and Resistance Exercise Intervention
Skeletal muscle, a dynamic tissue essential for movement and metabolic regulation, undergoes significant changes with age, leading to sarcopenia characterized by muscle mass decline and functional impairment. Moreover, short-term inactivity exacerbates sarcopenia, necessitating effective …
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Oxygen Generating Materials for Tissue Restoration and Regeneration
Traumatic injury to skeletal muscle produces a physiological deficit resulting in deterioration of tissue structure and function. The restoration or regeneration (i.e., tissue engineering) technologies required to effectively treat these injuries would benefit from provision of oxygen in situations …
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The role of individual protein turnover in skeletal muscle adaptation
Skeletal muscle tissue demonstrates a remarkable malleability and can adjust its metabolic and contractile makeup in response to alterations in functional demands. As a result, great diversity exists in muscle physiology, biochemistry and energy metabolism, all of which are underpinned by the …
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Synthesis and characterization of amino acid complexes of physiological metal ions to be used as ergogenic aids
… acids also play a crucial role in regulating muscle physiology during and after increased muscle exercise. Amino acid-based complexes with metal ions could overcome the current limitations in hydration therapy and also function as ergogenic aids during extended physical exercise. The current …
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Activation of smooth muscle and theories of contraction
… model of regulation of contraction of smooth muscle. The model involves twenty one parameters: sixteen rate constants, three initial conditions, and NT$\sb3$ and NT$\sb4$, where N is the number of crossbridges, and T$\sb3$ and T$\sb4$ are the tension of phosphorylated and dephosphorylated …
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Lattice Boltzmann method for integrating the Bloch equation in muscle fibers and microvessels
… diffusion and lipid concentration in the human muscle. Strong correlations have also been found between overall fitness and MRI measurements related to the transport of water inside the muscle fibers. In addition to water diffusion within the muscle, MR imaging has been used to obtain …
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The Role of BiP Co-chaperone SIL1 in Marinesco-Sjögren Syndrome Pathogenesis
… affected multiple pathways critical to muscle physiology. We observed an increase in ER chaperones prior to the onset of muscle weakness, which was complemented by up-regulation of multiple protein degradation pathways. These responses were inadequate to maintain normal expression of …
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Molecular Regulation of Mitochondrial Biogenesis in Exercised and Fasted Human Skeletal Muscle: an Examination of Emerging Regulatory Protein
… regulation of mitochondrial biogenesis in human muscle by examining the impact of exercise and fasting on regulatory protein with emerging roles in mitochondrial biogenesis. We first review the literature to critically evaluate the ability of PGC-1alpha to coordinate mitochondrial biogenesis in …
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Force potentiation as a modulator of contractile performance: Implications for control of skeletal muscle force and energetics of work
… contractile function during ramp shortening, and muscles were frozen during parallel incubations for biochemical analysis. The central feature of this research was the comparison of fast hindlimb muscles from wildtype and skeletal myosin light chain kinase knockout (skMLCK-/-) mice that does not …
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An exploration of muscle oxygen kinetics in professional boxing
… 1, the peripheral response of the rectus femoris muscle was investigated using NIRS wearable technology to determine the physiological demands of typical training modalities and a repeated sprint protocol in a sports science setting. 10 experienced professional boxers (age: 26±5 years, height: …
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Non-invasive Assessment of Swallowing and Phonation using High-density Electromyography
… (sEMG) provides detailed insights into muscle physiology and motor activity. However, the rapid, dynamic contractions and complex musculature involved present unique challenges for the application, processing, and analysis of high-density sEMG. This thesis developed two flexible …
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The Relative Importance of Four Muscle Groups for Rock Climbing Performance
The purpose of this study was to determine which muscle groups are most important for rock climbing. Eleven skilled male climbers were familiarized with an indoor climbing route before five separate days of testing. On testing days, subjects were randomly assigned a pre-fatiguing exercise designed …
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THE ROLE of THE CIRCADIAN CLOCK IN DISEASE and TISSUE FUNCTION
… tissue-specific gene expression and downstream physiology. The central pacemaker located in the hypothalamic suprachiasmatic nuclei (SCN) synchronizes the peripheral clocks in different tissues. This dissertation aims to uncover specific circadian regulatory mechanisms in the brain and skeletal …
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