Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"Muscle Atrophy"”.
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Drosophila Model to Study Muscle Atrophy
<p>Muscle atrophy (MA) is a phenomenon of muscle mass loss due to accelerated protein degradation in muscle fibers. Some pathological conditions, such as chronic inflammation or cancer, induce accelerated MA, which complicates medical treatment, hampers recovery of fragile patients, and ultimately …
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Cellular signalling pathways involved in muscle atrophy in cancer cachexia
… weight loss, characterised by the debilitating atrophy of adipose and skeletal muscle mass. Skeletal muscle proteolysis in cancer cachexia is mediated by a sulphated glycoprotein with a relative molecular mass of 24kDa, termed Proteolysis-Inducing Factor (PIF). PIF induced a significant increase …
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Investigation into the mechanisms responsible for muscle atrophy in cancer cachexia
… inducing factor (PIF), which induces skeletal muscle atrophy via increased protein degradation and decreased protein synthesis. The objective of this study was to investigate the signalling pathway by which PIF reduces protein synthesis in skeletal muscle and to determine the link, if any, to …
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Comparative Plasma Proteomics in Muscle Atrophy Induced by Cancer Cachexia and Hindlimb Unloading
<p>Introduction: Muscle atrophy results from a dysfunction in protein turnover that leads to loss of mass and function and occurs concurrently with multiple pathologies such as cancer and extended bed rest. Atrophy reduces overall quality of life while increasing morbidity and mortality. Currently, …
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Exploring The Relationship Between Mitochondrial-linked Cell Death And Muscle Atrophy During Ovarian Cancer Progression
The mechanisms underlying muscle atrophy during ovarian cancer are not fully understood. This study investigated the role of mitochondrial hydrogen peroxide (mH2O2)-mediated apoptosis and necroptosis in muscle atrophy using an orthotopic epithelial ovarian cancer (EOC) model at 40 and 80 days of …
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The Role of DNA Methylation in the Regulation of Skeletal Muscle Atrophy, Hypertrophy and Epigenetic ‘Memory’
Skeletal muscle mass is vitally important for the maintenance of health and quality of life into old age, with a plethora of disorders and diseases linked to the loss of this tissue. As a consequence, molecular biologists have extensively investigated both atrophying and hypertrophying skeletal …
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The Effects of Chronic Stress and Exercise on Mouse Pancreatic Islet of Langerhans Morphology and Muscle Atrophy Gene Expression
… increase insulin sensitivity at the level of the muscle and improve or maintain beta cell function and mass. To date, no published research has examined the effects of chronic stress in combination with voluntary wheel running on murine islet morphology and skeletal muscle atrophy. The purpose of …
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Sex-Based Differences in ACVR2B and GRB10 Expression in Skeletal Muscle During Induced Cancer Cachexia and Disuse
<p>Background: Muscle atrophy is the shrinkage of muscle fibers that are largely maintained by a balance of protein synthesis and degradation. Imbalances in protein synthesis and degradation are observed in different muscle atrophy disorders such as cancer cachexia and disuse. These forms of muscle …
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Aerobic Exercise-Mediated Prevention Against Glucocorticoid Myopathy in Aged Skeletal Muscle
… adults are vulnerable to glucocorticoid-induced muscle atrophy and weakness, with sex potentially influencing susceptibility to those effects. Aerobic exercise can reduce glucocorticoid-induced muscle atrophy in young rodents. However, it is unknown whether aerobic exercise can antagonize …
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The temporal relationship between cardiolipin biosynthesis and remodeling enzymes and cardiolipin content during unloading atrophy in mouse soleus
Skeletal muscle is a heterogeneous tissue that consists of individual fibers that differ in contractile and metabolic properties. Skeletal muscle is also dynamic in its ability to adapt to external stimuli through changes in cell size, number, and/or fiber type composition, which are matched by …
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Muscle structure and function in older adults with a rotator cuff tear
… age. Symptoms of a rotator cuff tear include muscle atrophy, fatty infiltration, decreased strength, and a loss of functional ability. However, a healthy aging process is also associated with atrophy, reduced strength, and declines in physical function. The goals of this dissertation were to …
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Contraction and cation contents of skeletal soleus and EDL muscles in age-matched control and diabetic rats
Skeletal muscle atrophy and neuropathy are two major long term complications of diabetes mellitus (DM). This study investigated the effect of streptozotocin (STZ) - induced type I DM on the characteristics of the animals and on contraction, cation contents, morphology and muscle proteins of …
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Development of a functional neuromuscular stimulation (FNS) muscle training program to prepare paraplegics for standing
… pressure, renal dysfunction, pressure sores, muscle atrophy and osteoporosis. Thus it would be beneficial, physiologically and psychologically, for a paraplegic to be able to stand for temporary periods of time. As a result of the muscle atrophy and functional degeneration that follows a …
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Enhanced dynamic load sensor for the International Space Station : design, development, musculoskeletal modeling and experimental evaluation
… leads to a reduction in bone mineral density, muscle mass, strength and endurance. Such deconditioning may impede critical astronaut activities and presents an increased injury risk during flight and when exposed to increased gravity like that of Earth or Mars. Exercise countermeasures are used …
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The effects of testosterone propionate on hindlimb immobilized rats
… been repeatedly demonstrated to cause pronounced atrophy of skeletal muscle. In animals and humans, disuse of a leg due to immobilization can cause pronounced catabolism of many skeletal muscle proteins. Strength, V02 max, oxidative enzyme activities, protein synthesis, and muscle weight are all …
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Sex Differences in Cancer Cachexia and a Novel Mitochondrial Target for Cancer-Induced Muscle Wasting
… by marked weight loss including skeletal muscle atrophy that affects approximately 80% of cancer patients. Current therapeutic treatments including pharmacological and nutritional intervention are insufficient to prevent or reverse it. Prior studies demonstrated lower muscle mass, impaired …
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An investigation of NADPH oxidase in normal and diseased skeletal muscle
… degenerative conditions, such as skeletal muscle wasting and therefore this study sought to determine a role for the superoxide generating NADPH oxidase and antioxidant enzyme systems in conditions of skeletal muscle wasting. The results of these studies indicated changes in the gene …
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Development of a device for whole body stimulation of the otoliths
… to Earth after prolonged spaceflight, extensive muscle atrophy due to adaptation to conditions of microgravity many times decreases a person's ability to walk or even stand, With an understanding of the anatomical mechanisms that provide postural control, the proper stimulation, resulting in a …
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