Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"Muscle, Smooth"”.
-
Structure-activity relationships of serotonin receptors in isolated smooth muscle
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Mechanism of Action of Pentobarbital Induced Attenuation of Vascular Smooth Muscle Contraction
… (10 Hz, 0.3 ms, 50 V, 30 sec), and direct smooth muscle (MEFS) stimulation in the presence of TTX (10 Hz, 3 ms, 50 V, 30 sec). Rings, preloaded at 1 g, were immersed in an organ bath filled with Krebs solution at 37°C, and aerated with 95% 02:5% CO<sub>2</sub>. PB (1 mM) attenuated only the …
-
Regulation of smooth muscle contraction by protein phosphorylation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Altered smooth muscle intracellular calcium signaling mechanisms in metabolic syndrome induced coronary artery disease
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
The roles of O₂, H⁺, and K⁺ in skeletal muscle functional vasodilation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Comparison of Receptor Efficacies on Vascular Smooth Muscle Contraction
<p>Vascular smooth muscle contraction involves multiple signal-transduction pathways, the interrelations of which are not completely understood. Our objectives in this project were to compare the effects of phenylephrine (alpha<sub>1</sub>-adrenergic agonist, angiotensin II (AT<sub>1 …
-
Regulation of Cardiac Fibroblast and Coronary Vascular Smooth Muscle Development by Platelet Derived Growth Factor Receptors
Coronary vascular smooth muscle cells (cVSMC) and cardiac fibroblasts are essential for coronary artery development and are important mediators of myocardial pathogenesis. These cells form when a subset of epicardial cells undergoes an epithelial-to-mesenchymal transition (EMT) and migrates into …
-
Mesothelial and Mural Cell Contribution to Vascular Development through PDGF Signaling
Vascular development during embryogenesis and adulthood occurs through vasculogenesis and angiogenesis. Vasculogenesis is the de novo formation of blood vessels from mesoderm precursor cells. Angiogenesis is the formation of new vessels from existing vessels. Both processes involve hematopoietic, …
-
An Intramural, Tension-modulating Reflex in the Rat Caudal Artery
… This relaxation is of either neuronal, vascular smooth muscle, and/or endothelial origins. We have shown that EFS-induced relaxation of intact, phenylephrine (PE) preconstricted rat tail artery (RTA) rings was dependent upon the extracellular concentration of Ca++. Inhibiting either nitric oxide …
-
Regulation of Ca2+-Activated K+ Channel: Changes with Development
<p>In ovine middle cerebral arteries, it has been shown that the [Ca<sup>2+</sup>]<sub>i</sub> change in response to iberiotoxin, a selective BK channel blocker, is significantly different between adult and fetal VSMCs. Our study of basilar VSMCs in whole-cell preparations showed that the total …
-
Isolation of the Cytosolic C-Terminus Segment of Mammalian Kca Channel a Subunit
<p>The last 20 years of research into ion channels has unraveled unexpected features of the BK<sub>ca</sub> channel as a rheostast for cell activity in excitable tissues and homeostatically fine tuning many biological activation processes in the cell. Great attention has been dedicated to the …
-
Postnatal Maturation Modulates Cerebrovascular Myogenic Tone
<p>The present study focused on the main hypothesis that maturation decreases contractile reliance on calcium influx and myofilament Ca2+ sensitivity, and increases reliance on release of calcium from intracellular stores to develop and maintain pressure-evoked myogenic tone in rat cerebral blood …
-
The Role of VEGF and Smooth Muscle Phenotype in Hypoxic Remodeling of Ovine Carotid and Cerebral Arteries
… in changes in status or behavior of the vascular smooth muscle within the vessel wall, likely secondary to changes in smooth muscle phenotype. This investigation examines the hypothesis that hypoxia induces vascular remodeling through transformation of vascular smooth muscle cell phenotype …