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Showing 1 to 20 of 27 for “"Muscle, Skeletal"”.
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Design, construction and testing of an innovative mechanism for manual wheelchair propulsion
… a standard wheelchair with less effort and muscle strain are being developed.;An innovative mechanism has been conceived, designed, built, and tested. It allows the user to propel a standard wheelchair in both the push and pull strokes of the handle. This new design will allow for a more …
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Regulation of Skeletal Muscle Innervation and ALS Pathogenesis by MicroRNA 206
Motor neurons and the skeletal muscle fibers they innervate maintain an intimate relationship that requires bidirectional signaling for the establishment and maintenance of neuromuscular synapses and muscle function. Abnormalities in the regulation of neuromuscular gene expression often result in …
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Control of Skeletal Muscle Fiber Types by Calcium Signaling Pathways
… drive distinctive programs of gene expression in skeletal muscles, thereby establishing a high degree of metabolic and physiological specialization among myofiber subtypes. Previous studies have demonstrated that calcineurin activity is required to maintain slow myofiber identity. I am interested …
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Molecular investigation if the rat jejunal active nucleoside transport protein rCNT1
… its presence has also been suggested in cardiac muscle, skeletal muscle and the spleen, although these observations await further confirmation.
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Fiber Orientation Modeling: a Method to Improve Quantitation of Intramyocellular Lipids in Human Subjects at 7 Tesla
… intramyocellular lipid (IMCL) content in skeletal muscle has been suggested to be a biomarker for insulin resistance. As a noninvasive method of estimating IMCL, 1H MR spectroscopy of muscle fat has been a popular method for measuring the concentration of IMCLs, a goal highly desirable for …
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The effects of maternal diets, varying in fat content, on proximal hepatic and skeletal muscle insulin signalling in neonatal wistar rat offspring
… in peripheral tissues such as the liver and skeletal muscle. Skeletal muscle is the major site for insulin stimulated glucose uptake. Maintenance on a gestational high fat diet may programme insulin resistance. Programming is induced by the exposure of organisms to either a stimulus or insult …
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COMPARISON OF EQUINE BONE MARROW-, UMBILICAL CORD MATRIX-, AMNIOTIC FLUID- AND TENDON-DERIVED PROGENITOR CELLS
… resonance with particular attention to the muscle-skeletal tissues.
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Myogenic Effectors and Disease
Skeletal muscle is essential for life. Inside muscle fibers, filaments of actin and myosin slide on each other to generate the mechanical forces that drive muscle contraction, movement, and breathing. Mutations in muscle-related genes can cause severe diseases in humans. Here we characterize the …
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Selected exercise and skeletal muscle characteristics of African distance runners
… this thesis was to compare selected exercise and skeletal muscle characteristics in well-trained African and Caucasian 10 km runners to determine if evidence exists of differences between these groups with respect to these physiological and biochemical characteristics. Furthermore, the …
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Durability and Longevity of Gene Edited DMD Skeletal Muscle
The content of this work is adapted with or without modifications from the previously published articles that are cited below. Sections that have been reproduced from previously published work have been clearly indicated at the beginning of each section.
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Discovery and Characterization of Genes Involved in Muscle Calcium Handling
Muscle tissue requires continuous cycling of calcium release and clearance to generate and sustain contraction. When the plasma membrane of a muscle fiber becomes electrically excited, a voltage sensor in the membrane, called the dihydropyridine receptor (DHPR), becomes activated and signals to the …
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Voltage-Gated Sodium Channel Activity in Mouse Skeletal Muscle Fibers: Normal Gating and Defects Associated with Periodic Paralysis Mutants
Mutations in SCN4A, the gene encoding the skeletal muscle Na+ channel (NaV1.4) α-subunit, cause several disorders related to skeletal muscle excitability. The functional consequences of these NaV1.4 mutations have been extensively characterized in heterologous expression systems. These studies have …
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The Effects of Zinc on Skeletal Alkaline Phosphatase Activity and Skeletal Tissues
<p>Zinc is essential for normal growth, however, very little is known about the mechanisms by which zinc influences growth. ALP, an ectoenzyme expressed in high levels in osteoblasts, is a zinc-containing metalloenzyme and is important in bone formation. Preliminary studies showed that low levels …
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The impact of cytotoxic chemotherapy on somatic mutation in normal human cells
… of post-mitotic cells such as cardiac muscle, skeletal muscle and the neuron-rich cerebellar granular layer, which have historically been considered not to acquire substantial numbers of somatic mutations during adult life. These burdens are associated with signatures of platinum-based …
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Investigating the Function of an Actin Nucleation-Promoting Factor N-WASP in Mammalian Myoblast Fusion
Pages 61-89 are misnumbered as pages 75-103, and pages 90-100 are misnumbered as pages 102-112.
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Influence of Gender and Aerobic Training Background on Exercise-Induced Increase in Adiponectin
Adipose tissue secretes the adipokine, adiponectin (ADPN), which is insulinsensitizing, anti-inflammatory, and anti-atherogenic. Exercise training improves insulin sensitivity and lowers the risk of cardiovascular complications. As some of the metabolic effects of exercise training and ADPN …
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The Effect of Cervical Muscle Fatigue on Postural Stability during Immersion Virtual Reality
… how motion sensitivity is impacted by neck muscle fatigue in normal healthy participants. The overall aim of the present work was to investigate whether impaired somatosensory information from the cervical spine, caused by neck muscle fatigue, would negatively impact postural stability in …
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Investigating The Effect Of Chronic Muscle Use And Disuse On Innate Immune Signaling In Skeletal Muscle
Skeletal muscle health is highly dependent on the intricate mitochondrial reticulum that exhibits high levels of adaptability. It is now recognized that mitochondrial perturbations can activate innate immune pathways, such as the NLRP3 inflammasome complex, by augmenting the response against …
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Muscle Dynamics as the Result of Whole Body Vibration and Plyometrics
<p>BACKGROUND: Whole body (WBV) vibration and plyometrics are common training techniques which increase strength, blood flow, force and power. The effects these techniques have on sedentary population is unknown. It is our aim to assess the effectiveness of WBV and plyometrics on sedentary …
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THE ROLE OF INNERVATION IN ENGINEERED MUSCLE
Skeletal muscle injuries span a wide spectrum, from minor strains to devastating traumatic events, and represent a significant clinical challenge worldwide. Millions of individuals experience severe muscle deficits each year, including volumetric muscle loss (VML) resulting from ballistic trauma, …
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