Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Murine xenograft model"”.
-
Investigations into the role of inflammation in tumorigenesis
… HS both as an experimental and translational model, we sought to create a murine xenograft model. In Chapter 5, we discuss the development of our model and the results of pilot studies using targeted drug therapy. The focus of Chapters 3-5 is to further explore the role of inflammation in the …
-
Analyzing The Role of Αvβ8 Integrin In Glioma-Induced Angiogenesis
… glioblastoma multiforme (GBM). Indeed, a murine xenograft model of astrocytoma suggested a role for the integrin in glioma-induced angiogenesis. Primary mouse astroglia were cultured from wild type (WT) and β8 KO neonates and were immortalized (HPV:E6/E7) and transformed (HRas:G12V). WT …
-
Polymerizable Peptide Monomers for the Targeted and Intracellular Delivery of Cancer Therapeutics
… polymeric carrier via disulfide exchange. In a murine xenograft model of B-cell lymphoma, steric hindrance significantly enhanced conjugate stability, peptide half-life and peptide deposition into tumors. However, benefits were relatively minor with much left to be desired. Next an enzyme-labile …
-
Procaspase-3 activation as a strategy to overcome resistance to targeted anticancer therapies
… significant reduction in tumor volume in a murine xenograft model of BRAFV600E melanoma, beyond the antitumor effects of the individual agents. In addition, the combination is also effective in significantly delaying the regrowth of cells after exposure to vemurafenib. Finally, PAC-1 remains …
-
An Activity-Based Proteomics Approach for Identifying Ajoene's S-thiolation Protein Targets in Blood and Cancer Cells
… of ajoene and selected derivatives in a murine xenograft model for human oesophageal cancer (WHCO1). This concluded, disappointingly, that no significant differences in terms of tumour volume, mass and growth rate were observed compared to an untreated control. A follow-up study using a …
-
Novel immunotherapy for paediatric cancers
Chimeric antigen receptors (CAR) are synthetic receptors that redirect T lymphocytes to specific tumour antigens. CART cells targeting CD19 (CAR19) have demonstrated remarkable efficacy against B cell malignancies in clinic. Currently used methods of CAR gene transfer to T cells based on viral …