Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 292 for “"Murine model"”.
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A murine model of developmental programming of atherosclerosis
… metabolic syndrome is well established. Animal models are a central tool to investigate the details and mechanistic basis of the effects of the early life milieu. \r\nCoronary artery disease secondary to atherosclerosis remains a major cause of death in most societies. Limited human studies …
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Female-Specific Mechanisms of Nociplastic Pain in Murine Model
… studies on nociplastic pain, we developed a murine model in which postinjury thermal stimulation of injured area triggers the transition to a nociplastic pain state more readily in females. This model manifested mechanical hypersensitivity outside the previously injured area beyond the normal …
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Bi-directional tumour-host interaction in a murine model
… characterised for two histologically distinct murine tumours grown in immunocompetant, syngeneic mice. Immunological response profiles were defined in terms of lymphocyte proliferation, cytotoxic function and lymphocyte subsets in naive non-tumour bearing mice and mice with increasing tumour …
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Atrial arrhythmogenesis in a murine model of mitochondrial insufficiency
… in their pathogenesis was investigated using a murine model with homozygous deficiency of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1 β (Pgc-1β-/-). Pgc-1β regulates mitochondrial biogenesis and function, and unlike other murine models of …
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Male-specific mechanisms in a murine model of nociplastic pain
… transition to nociplastic pain, we developed a murine model in which acute injury-induced mechanical hypersensitivity was prolonged beyond its normal resolution time following postinjury stimulation at normally innocuous intensity. This model utilized intraplantar capsaicin injection or plantar …
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Male-specific mechanisms in a murine model of nociplastic pain
… transition to nociplastic pain, we developed a murine model in which acute injury-induced mechanical hypersensitivity was prolonged beyond its normal resolution time following postinjury stimulation at normally innocuous intensity. This model utilized intraplantar capsaicin injection or plantar …
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Mechanisms of inflammation resolution in a murine model of Lyme arthritis
… in inflammation resolution mechanisms. In the murine model of Lyme arthritis (mLA), B. burgdorferi infection of C3H/HeJ mice induces a self-limiting arthritis, allowing the study of both the development and resolution of inflammation. Our primary interest is the role of bioactive lipid …
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Genomic Instability and the Oncohistone H3K27M Drive Gliomagenesis in a Murine Model
… power of inducible genetically engineered mouse models as an approach to better understand the complexities of providing a connection between genome instability and gliomagenesis.</p>
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Natural Stressors, Posttraumatic Stress Disorder, and Wound Healing, in a Murine Model
… etiology of Posttraumatic Stress Disorder in a murine model. Pilot data suggest that stress effects may lead to an increase in the amount of time needed for cutaneous wounds to heal. Pilot data to support the creation of this model are presented suggesting that a delayed stress response may …
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EXERCISE-INDUCED ORGAN PROTECTION IN A MURINE MODEL OF CARDIAC ARREST AND RESUSCITATION
… injury. Furthermore, characterization of the murine electrocardiogram during and immediately following resuscitated cardiac arrest is exceedingly limited in the current literature. Thus, a clear knowledge gap exists in the methodology of murine models of arrest which we attempted to fill. We …
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Pregnancy Induced Alterations of Reproductive Tract Collagen and Elastin in a Murine Model
… are fragmented and highly tortuous. Our current model suggests that the elastic fiber fragmentation, which occurs over length scales of approximately 10-50 micrometers (the length of an elastic fiber), together with collagen content may play a crucial role in tissue scaffolding than alterations …
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Congenital Chagas Murine Model Development and Nanovaccine Efficacy Against Maternal-fetal Trypanosoma cruzi Pathogenesis
… disease (cCD). The objective was to develop a murine model of cCD to test the efficacy of a DNA nanovaccine developed by our laboratory. In this dissertation, we demonstrate that Tc infection in female mice delayed the initiation of pregnancy, reduced fertility rate, and resulted in vertical …
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The role of inflammasomes in a murine model of acute respiratory distress syndrome (ARDS)
… a key driver in the development of ARDS in this model. NLRP3 has a potential role in the resolution phase of lung injury because NLRP3 protein deficiency caused prolonged lung injury which was associated with increased total cell numbers in the lung on day 7 post-injury, i.e., the resolution …
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Neurochemical Monitoring in a Humanised Murine Model of Parkinson’s Disease using Amperometry and Microdialysis
… sampling. The development of a humanised mouse model of PD provides an invaluable tool in which to study PD in a physiological setting. By application of amperometric sensors and microdialysis sampling in these PD models, the functional neurochemical behaviour of the PD can be assessed in vivo. …
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Investigating DNA Methylation Changes in a Preclinical Murine Model of Cutaneous Squamous Cell Carcinoma
… to treat aggressive cSCC.<br/><br/>Most animal models only partly reflect the complex genetic landscape of cSCC or leave out important parts of the carcinogenic process. We have developed a preclinical mouse model for cSCC by irradiating SKH-1 mice with low chronic doses of solar simulated UVR. …
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The role of Cysteinyl leukotriene receptor-1 during experimental helminth infections in murine model
… cysLTR1 during different helminth infection models. Absence of cysLTR1 during N. brasiliensis leads to delayed expulsion of adult worms and impaired recall of memory responses, indicating that cysteinyl leukotriene signaling via cysLTR1 is essential for orchestrating host protective …
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DENDRITIC CELLS IN A MURINE MODEL OF BREAST CANCER: FUNCTIONAL AND PHENOTYPIC EVALUATION USING NANOPARTICLES
… immune response activation. Studies on mice models reported that tumoral antigens-loaded DCs can induce therapeutic and protective anti-tumour immune responses, both in vitro and in vivo. These results provide an evidence of the possible use of DCs as vaccines. However, the efficacy of such …
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