Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Murine Norovirus"”.
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Identification of Viral Determinants of Murine Norovirus Pathogenesis
Human noroviruses are responsible for the majority of cases of epidemic non-bacterial gastroenteritis. Despite their importance as human pathogens, knowledge of the viral life cycle and host pathogenesis is limited due to the lack of practical models to study. In contrast, murine norovirus: MNV) …
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Factors That Influence Murine Norovirus Stability and Tropism
… this work I investigated factors that influence murine norovirus stability and tropism through two independent projects. Murine norovirus (MNV) is a model system used to study human noroviruses due to its robust replication in cell culture and mouse model. I first investigated the interactions …
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UV light inactivation of adenovirus, coxsackievirus and murine norovirus
The overall objective of this research project is to evaluate the efficiency of low-pressure (LP) and medium-pressure (MP) UV light irradiation to inactivate waterborne pathogens that are an increasing concern in drinking water. The inactivation of pathogens depends directly on the total UV dose or …
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Modulators of Innate Gut Immunity to Enteric Viral Infections: Murine Norovirus (MNV) as a Model
… the extremes of age. In this thesis, using the Murine Norovirus (MNV) oral infection model, I aimed to characterize intestinal mucosal antiviral-responses with specific focus on the role of IELs, the impact of aging and the influence of certain micronutrients whose effects are mediated through …
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Investigating the Effects of Glycochenodeoxycholic Acid on Mutant Murine Norovirus P-Domain Structure and Antibody Interactions
… is most frequently caused by exposure to norovirus (NoV) through fecal–oral transfer resulting in severe vomiting and diarrhea lasting between 24 to 48 hours, yet for certain individuals, these infections can be fatal. With epidemic strains continuously emerging, it is imperative to …
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Identification of host cellular factors that regulate human norovirus replication
The human norovirus (HuNoV) is one of the most predominant causes of gastroenteritis, yet no suitable therapeutics are available for its control. Currently, our knowledge of the precise cellular processes that control its replication is limited. In this study, we used the virus replicon system in …
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Innate sensing and regulation during enteric caliciviruses infections
Several decades after the discovery of the human norovirus, with thousands of lives and billions of dollars lost, the lack of a robust cell culture system still severely hampers development of vaccines and therapeutics. This is likely in large part as a result of our limited understanding of the …
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The Role of MDA5 and TLR3 in Response to dsRNA and Viral Infection
… infection. Using two models of viral infection, murine norovirus: MNV) and encephalomyocarditis virus: EMCV), we demonstrate that both MDA5 and TLR3 limit viral replication. Neither MDA5-/- nor TLR3-/- animals controlled MNV and EMCV infection as well as wild type: WT) controls, but DKO mice were …
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New Approaches to the Development of Peptoid Vaccines
… antibodies against West Nile virus and murine norovirus type 1. In addition, the immunogenicity of peptoids was further examined by designing a peptoid-carrier, using it to immunize rabbits, and demonstrating that anti-peptoid antibodies could be affinity-purified from the resulting …
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Norovirus Translation and Replication
Human norovirus (HuNoV) is the leading cause of gastroenteritis worldwide. Despite the significant disease and economic burden, currently there are no licensed vaccines or antivirals. The understanding of norovirus biology has been hampered by the inability to cultivate HuNoV in cell culture. To …
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Characterisation of the Mechanism of Norovirus VPg-Nucleotidylylation
Noroviruses, which belong to the *Caliciviridae* family, have a substantial yearly impact on the global economy of about $60 billion and cause about 200,000 deaths per annum in children under the age of 5. Despite causing most cases of viral gastroenteritis, noroviruses remain poorly characterised …
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Incorporation of selected plant extracts into edible chitosan films and the effect on the antiviral, antibacterial and mechanical properties of the material
… GTE solutions significantly (p<0.05) reduced murine norovirus (MNV-1) plaques by 1.69, 2.47, and 3.26 log after 3 h exposure, respectively. Similarly, the FFS containing 2.5 and 5.0% GTE reduced MNV-1 counts by 2.45 and 3.97 log10 PFU/ml, respectively after 3 h exposure. Additionally, the …