Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Munc18-1"”.
-
Insights into the Functions of Munc18-1 in Neurotransmitter Release
… membrane fusion machinery in neurons includes Munc18-1 and the SNARE proteins syntaxin-1, SNAP-25 and synaptobrevin. The SNAREs form tight SNARE complexes that bring the vesicle membrane and plasma membrane into close proximity and provide forces to induce membrane fusion. Munc18-1 is essential …
-
Munc18-1 Is a Master Orchestrator of Synaptic SNARE Assembly
Pages 114-185 are misnumbered as pages 115-186.
-
Structural and Functional Studies of Munc18 and SNARE Proteins
… of this machinery are proteins from the Sec1/Munc18 (SM) and SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptors) families. SNAREs function by forming a four-helix bundle called SNARE complex; assembly of the SNARE complex brings two membranes together and is key for …
-
Fluoreszenzmikroskopische Studien an Plasmamembranen zur Untersuchung der molekularen Mechanismen der neuronalen Exocytose
… Membranen fusioniert. Neben den SNAREs ist auch Munc18-1, das zur Sec1/Munc18-Proteinfamilie gehört, ein essentielles Protein der neuronalen Exocytose. Der Munc18-1-Knockout führt zum Block der neuronalen Exocytose. In vitro bildet Munc18-1 mit Syntaxin1 einen Komplex, der Syntaxin1 in einer …
-
Fluoreszenzmikroskopische Studien an Plasmamembranen zur Untersuchung der molekularen Mechanismen der neuronalen Exocytose
… Membranen fusioniert. Neben den SNAREs ist auch Munc18-1, das zur Sec1/Munc18-Proteinfamilie gehört, ein essentielles Protein der neuronalen Exocytose. Der Munc18-1-Knockout führt zum Block der neuronalen Exocytose. In vitro bildet Munc18-1 mit Syntaxin1 einen Komplex, der Syntaxin1 in einer …
-
Munc18 function in large dense-core vesicle exocytosis
… essential in later steps of exocytosis. The Sec1/Munc18 proteins are also essential in exocytosis and other membrane trafficking processes but their molecular and cellular function is less clear than that of the SNARE proteins.In our work we studied the role of Munc18 in large dense-core vesicle …
-
Structural and Functional Studies of the Munc13 MUN Domain and the RIM C2B Domain
… fusion machinery includes the SNARE proteins and Munc18- 1. Besides these universal components, many other neuronal specific proteins are also involved in regulating Ca2+-triggered neurotransmitter release, such as the key priming factors RIMs and Munc13s. Munc13s are essential for vesicle …
-
Unraveling the Role of SNARE Interactions in Neurotransmitter Release
… a 'closed' conformation, which interacts with munc18-1, an essential protein in the neurotransmitter release. It has been proposed that the binding of munc18-1 might change the closed conformation. To test this model, I solved the solution structure of the N-terminal domain within the closed …
-
Dissecting Roles for the Macromolecular Machinery Involved in Neurotransmitter Release
… in the presence of NSF-αSNAP requires both Munc18-1 and Munc13-1, and is facilitated by synaptotagmin-1. I proposed a model whereby Munc18-1 and Munc13-1 are critical for mediating vesicle priming as well as precluding de-priming by preventing trans-SNARE complex disassembly. Complexin-1 …
-
Unraveling the Functions of Synaptotagmin and Munc13 in Neurotransmitter Release
… sensitive factor adaptor protein receptor) and Munc18-1 as core components. Munc13, synaptotagmin and complexin underlie the exquisitely tight regulation of synaptic exocytosis. The SNAREs form the SNARE complex that brings synaptic vesicles and plasma membrane together. This complex is …
-
Molecular Mechanisms of Presynaptic Plasticity and Function in the Mammalian Brain
… kinase C (PKC) isoforms that phosphorylate Munc18-1 proteins. It is unknown how generally applicable this mechanism is throughout the brain and if other proteins might be able to modulate PTP. Combining genetic (PKCαβy triple knockout [TKO] and Munc18-1SA knock-in [Munc18 KI] mice, in which …