Global ETD Search
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Showing 1 to 9 of 9 for “"Munc18 Proteins"”.
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The Role of Munc18 Proteins in Physiologic and Pathologic Exocytoses in the Pancreatic Acinar Cell
… interactions between distinct sets of SNARE proteins forming exocytotic complexes, whose assembly is modulated by distinct Munc18 proteins. The Munc18 isoform responsible for these exocytotic events in the acinar cell is unknown. Here, I postulate Munc18b to regulate apical exocytosis in the …
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Reconstitution of Munc18-Dependent Mast Cell Degranulation
… membrane fusion machinery. These proteins, called SNAREs are regulated by the Sec1/Munc18 (SM) protein family (Axle Lorentz, Baumann, Vitte, & Blank, 2012). Mast cells express three mammalian Munc18 isoforms (a, b, and c), which are linked to SNARE-dependent exocytosis in numerous …
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Packaging and Secretion of Airway Mucins
… take place on a scaffold provided by a Munc18 protein. Prior work in the Dickey-Tuvim laboratory has shown that different Munc18 proteins mediate baseline and stimulated mucin secretion, indicating that different plasma membrane exocytic machines underlie baseline and stimulated mucin …
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Munc18 function in large dense-core vesicle exocytosis
… sequential steps of exocytosis are executed by proteins and protein complexes. Formation of the SNARE complex is essential in later steps of exocytosis. The Sec1/Munc18 proteins are also essential in exocytosis and other membrane trafficking processes but their molecular and cellular function is …
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Munc18-1 Is a Master Orchestrator of Synaptic SNARE Assembly
Pages 114-185 are misnumbered as pages 115-186.
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Structural and Functional Studies of Munc18 and SNARE Proteins
… Essential components of this machinery are proteins from the Sec1/Munc18 (SM) and SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptors) families. SNAREs function by forming a four-helix bundle called SNARE complex; assembly of the SNARE complex brings two membranes …
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Insights into the Functions of Munc18-1 in Neurotransmitter Release
… triggered by Ca2+. Several conserved proteins are involved in regulating the entire process. The central membrane fusion machinery in neurons includes Munc18-1 and the SNARE proteins syntaxin-1, SNAP-25 and synaptobrevin. The SNAREs form tight SNARE complexes that bring the vesicle …
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Unraveling the Functions of Synaptotagmin and Munc13 in Neurotransmitter Release
… sensitive factor adaptor protein receptor) and Munc18-1 as core components. Munc13, synaptotagmin and complexin underlie the exquisitely tight regulation of synaptic exocytosis. The SNAREs form the SNARE complex that brings synaptic vesicles and plasma membrane together. This complex is …
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Dissecting Roles for the Macromolecular Machinery Involved in Neurotransmitter Release
… in the presence of NSF-αSNAP requires both Munc18-1 and Munc13-1, and is facilitated by synaptotagmin-1. I proposed a model whereby Munc18-1 and Munc13-1 are critical for mediating vesicle priming as well as precluding de-priming by preventing trans-SNARE complex disassembly. Complexin-1 …