Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Multivariate Curve Resolution"”.
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CHARACTERIZATION OF WATER MEDIATED HYDROPHOBIC AND IONIC INTERACTIONS USING RAMAN SPECTROSCOPY
Raman spectroscopy can be combined with multivariate curve resolution (MCR),
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Tissue spectroscopic characterization based on fluorescence, second harmonic generation, and reflected light
… methods - spectral image guided analysis and multivariate curve resolution. This instrument has been applied to the study of human skin luminescence species and in a photoaging study of a skin equivalent model. Second, tri-modal microscopy combines two-photon fluorescence with second harmonic …
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Quantification of molecular aggregation equilibria using spectroscopic measurements and random mixing modeling
… Raman vibrational spectroscopy is combined with multivariate curve resolution (Raman-MCR) to experimentally quantify both the number of hydrophobic contacts between alcohol molecules in water and the affinity of ions for molecular hydrophobic interfaces. Furthermore, a generalized theoretical …
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The use of ATR-FTIR to probe the release mechanism from hydrophilic matrices.
… approaches, such as peak area changes, and multivariate curve resolution (MCR) were applied to these datasets. The MCR studies showed some promise, but also highlighted a need for further development. The standard data analysis showed that the rate of release of the API and citric acid was …
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Multimodal spectroscopy : real-time diagnosis of breast cancer during core needle biopsy
… fluorescence and DRS spectra and analyzed using multivariate curve resolution. Raman spectroscopy data were fit using a linear combination of Raman active components (e.g. collagen, calcium, adipose) found in breast tissue. Prospective validation of Raman spectroscopy resulted in sensitivity and …
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Understanding Radiation Resistance in Head and Neck Tumor Xenografts Using Diffuse Reflectance and Raman Spectroscopy
… collected and the spectra were analyzed using multivariate curve resolution-alternating least squares (MCR-ALS) and pure spectral profiles of biological specimen were extracted. We observed higher contributions to Raman spectra from lipid- and collagen-like species respectively in …
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Mid-IR Imaging and Multivariate Analysis of Dynamic Processes in Pharmaceutically Relevant Microparticles
… the development and optimisation of relevant multivariate image analysis methods for studying the real-time degradation of pharmaceutically relevant biodegradable polymer microparticles and the real-time release of protein based drugs from such microparticle systems. The application of …
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Application of fluorescence spectroscopy for the in-vial investigation of protein solutions
… fluorescence for 4 different proteins. Using a multivariate technique, multivariate curve resolution to resolve 3D emission excitation spectra, the fluorescence of individual amino acid solutions and the total fluorescence of the proteins was correlated. Finally, a partial least squares …
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Étude de données spatio-temporelles pour l’analyse du contrôle environnemental en milieu industriel pharmaceutique
Une quantité importante de procédés industriels sont aujourd’hui monitorés à l’aide de capteurs et d’analyses afin d’avoir de l’information sur l’état des opérations et faciliter la réponse à d’éventuelles déviations. Bien que l’analyse de ces données soit une pratique de plus en plus courante dans …
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Applications and developments of chemometric methods for process analytical chemistry
… upsets to allow the batch to be corrected. Multivariate curve resolution (MCR) was used to extract the concentration profiles from the MW and NIR spectra, and these profiles used to calculate the rate constants, k of the reaction. The MW and NIR calculated k values do not agree, suggesting …