Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Multivalent ligands"”.
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Design, Synthesis and Study of Novel Multivalent Ligands - Toward New Markers of Cancer Cells
… towards cancer cells, we propose the use of multivalent interactions targeting specific receptor combinations at the cancer cell surface. In this thesis, we explored the design of multimers, which could provide such interactions. The design was investigated and revisited based on specific …
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The synthesis of WAY-derivatives to find linker location and a new linker to attach a fluorescence tag for homo- or hetero-dimer of 5-HT receptor ligands
… has been on the synthesis and bioactivity of multivalent ligands of M100907 and WAY 163909 for homo- and hetero dimeric ligands. As an extension of previous research, this study includes development of WAY derivatives, which can be developed for homo- or hetero dimeric ligands. In addition, a …
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Relating structure and function: Discovery of novel inhibitors of myotonic dystrophy
… binding mode but also to the development of new ligands through structure-based drug design. The design of base binding ligands was validated by X-ray crystallography. These principles are further investigated in Chapter 3, where the repeated structure of the DNA and RNA targets were used to …
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Design, synthesis and characterization of new iron and aluminium chelating agents
… the following aims: Design and synthesis of new multivalent ligands in order to enhance the efficiency and selectivity of both metal-interaction and biomolecular recognition of available ligands (or metal complexes), as well as the targeting for drug delivery; Assessment of the most important …