Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Multivalent Binding"”.
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Probing DNA-Induced Colloidal Interactions and Dynamics with Scanning-Line Optical Tweezers
… between pairs of polystyrene microspheres at binding strengths comparable to those used in self-assembly experiments. The pair-interaction energies measured with our optical tweezers instrument can be modeled quantitatively with a conceptually straightforward and numerically tractable model, …
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Computational insights into multivalently binding polymers
Multivalent binding is commonly used throughout biology to create strong, conformal bonds using multiple weak binding interactions simultaneously. Bonds are considered multivalent when multiple ligands on one species simultaneously bind to multiple receptors on another species. Together, this bond …
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Experimental and Computational Studies in Bioorganic and Synthetic Organic Chemistry
… Ï interaction. In nature, dramatic increases in binding affinity can be achieved through multivalent binding. Following a fragmentation-dimerization approach, we synthesized Taxol-based dimer in which the baccatin III core of Taxol is coupled with flexible PEG linker. However, microtubule …
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Targeting RNA Structures with Multivalent Branched Peptide Libraries
… library designed to target RNA was screened for binding to RRE. Each of these efforts resulted in the identification of selective binders to their respective RNA targets, and the unnatural branching of these compounds was demonstrated to provide a multivalent binding interaction with the RNA. …
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Modelling multivalent interactons
A Multivalent entity, which could represent a protein, nanoparticle, polymer, virus or a lipid bilayer, has the ability to form multiple bonds to a substrate. Hence, a multivalent interaction can be strong, even if the individual bonds are weak. However, much more interestingly, multivalency …
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Saccharide recognition : boronic acids as receptors in polymeric networks
… and the characterisation of saccharide binding by means of isothermal titration calorimetry and displacement assay (ARS) to enhance the association constant to saccharides at pH 7.4 • Enhancement of selectivity in polymeric systems by means of molecular imprinting using fructose as …
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Interactions between nucleoid associated proteins and DNA in the presence of mechanical and chemical forces
… elucidate how their physical properties (such as binding kinetics or DNA manipulation) aid in regulating cell function. It has been shown in experiment and simulation that NAPs can adopt multiple binding states (i.e., the protein can be partially associated with its DNA substrate), which leads to …
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Making Molecular Movies: Using Single-Molecule Techniques to Unveil Hidden Features of Protein-Chromatin Interactions
… that regulates the function of every DNA-binding protein that exists. These proteins can assemble, translocate, and change conformation while bound to DNA and can even alter its physical state, which are often crucial to their physiological roles in the cell. Eukaryotic genomic DNA is also …