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Showing 1 to 20 of 237 for “"Multivalent"”.
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Modelling multivalent interactons
A Multivalent entity, which could represent a protein, nanoparticle, polymer, virus or a lipid bilayer, has the ability to form multiple bonds to a substrate. Hence, a multivalent interaction can be strong, even if the individual bonds are weak. However, much more interestingly, multivalency …
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Multivalent Supramolecular Systems
… deals with the study of chelate cooperativity in multivalent supramolecular systems. Firstly, a well-known H-bonded rosette system was revisited and the effective molarity was determined experimentally by 1H NMR titrations to be around 2 M, which is a high chelate cooperativity compared to other …
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Phase Transitions of Multivalent Adaptor Proteins
… proposes a hypothesis based on polymerization of multivalent proteins that causes these complexes to phase separate in solution. The behavior of multivalent proteins and their ligands to phase separate may be a general property that allows cells to regulate their activities in certain localized …
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Development of Electrolyte Salts for Multivalent Ion Batteries
… of new electrolyte salts for rechargeable multivalent ion batteries. In chapters 2 and 3 the synthesis of Mg and Ca hexafluoropnictogenate salts as well as the electrochemical behaviour of Mg(PF6)2 is presented. Pure samples of Mg(EF6)2 (E = P, As, and Sb) can be synthesized using Mg metal …
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Targeting RNA Structures with Multivalent Branched Peptide Libraries
… of these compounds was demonstrated to provide a multivalent binding interaction with the RNA. Furthermore, these compounds were shown to be cell permeable and displayed little to no cytotoxicity in HeLa and A2780 cells.
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Exploring multivalent technologies and strategies for directed protein evolution
… during the selection process, a new in vitro multivalent selection system was developed, that allowed for the display of proteins of interest under defined valencies. Using this system, different valency effects could be quantified and mapped. The observations of vastly improved recoveries and …
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Better multivalent battery materials through diffusion high-throughput computations
Accelerating the discovery of advanced materials is essential for human beings. However, the traditional trial-and-error way of developing materials is often very empirical and time- consuming. In 2011, the launch of Materials Genome Initiative marked a large-scale collaboration between computer …
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Development of a flagellin-based multivalent vaccine against Pseudomonas aeruginosa
… goal of my research was to establish whether a multivalent vaccine containing P. aeruginosa type A and B flagellins as well as the outer membrane proteins OprF and OprI would promote enhanced clearance of P. aeruginosa. To test this I utilized two animal models, mice and 4-6 month old African …
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Multivalent Programmable Interactions Between Lipid Vesicles: Towards Responsive Soft Materials
… with a variety of structures. More recently, multivalent interactions have been exploited to drive self-assembly of nanoparticles, hard colloids and compliant units including emulsion droplets and lipid vesicles. By applying this to deformable lipid vesicles, formation of links between two …
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Thermodynamics and kinetics of Mg intercalation for multivalent cathode applications
Energy storage, especially through electrochemical mechanisms such as batteries, is crucial for sustaining the ever-increasing energy needs of the future in a fossil-free manner. While the current industrial workhorse, lithium ion batteries, has shown tremendous improvements in energy and …
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Solar desiccant evaporative cooling with multivalent use of solar thermal heat
… with coexisting heating demand particularly, a multivalent system approach that utilizes solar-heat not only for air-conditioning but also for hot water preparation and heating has potential as a feasible concept. However, previous research focused on systems using solar heat exclusively for the …
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Multivalent Random Walkers:A computational model of superdiffusive transport at the nanoscale
… rates in artificial molecular systems. Our \emph{multivalent random walker} model describes the motion of a walker with a rigid, inert body and flexible, enzymatic legs. A leg can bind to and irreversibly modify surface-bound chemical substrate sites arranged as nanoscale tracks. As the legs …
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Design, Synthesis, And Testing Of Multivalent Compounds Targeted To Melanocortin Receptors
… stimulating hormone receptors. A successful multivalent construct should show greater avidity towards melanoma cells than healthy cells due to the synergistic effects arising from multivalency. Both oligomeric and shorter linear constructs bearing the minimum active sequence of melanocyte …
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Electrodeposition and speciation processes of multivalent metals for next generation batteries
Made available in DSpace on 2020-10-07T22:48:06Z (GMT). No. of bitstreams: 3 TA-DISSERTATION-2020.pdf: 4971482 bytes, checksum: 0f3c243cc42c7c69a390ca8a96c80a45 (MD5) LICENSE.txt: 4203 bytes, checksum: 5e1abe676aebe4555d7f7816e803330c (MD5) PROQUEST_LICENSE.txt: 4549 bytes, checksum: …
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Design and synthesis of mechanoresponsive materials and multivalent polymer-peptide conjugates
… are subjected to mechanical force. Second, multivalent polymer-peptide conjugates (mPPCs) are synthesized by the post polymerization modification of a polymer backbone with peptides and interact with amyloid beta to inhibit its aggregation. These examples of functionalized polymers elucidate …
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Nanoscale defect engineering and mapping for cathode materials of multivalent ion batteries
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
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Multivalent activation in temporary phosphate tethers: A new tether for small molecule synthesis
… esters as temporary tethers, capable of multivalent activation is the broad focus of the dissertation research reported herein. Specifically, the utility of phosphate tethers has been demonstrated through the divalent activation of allylic C2-symmetric monocyclic phosphates. Within these …
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Development of a broadly protective protein-based multivalent vaccine against cholera and beyond
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01
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Characterizing Multivalent Interactions Between Folded Protein Domains and Intrinsically Disordered Regions or Peptide Substrates
<p>Protein-protein interactions (PPIs) play central roles in most biological processes. Studying PPIs is a fundamental step in understanding the molecular basis of cellular processes such as cell-cell contact, enzyme activity, and transient assembly of signaling complexes or cellular structures. In …
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