Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 33 for “"Multivalency"”.
-
A Platform for Analyzing Force Sensitivity and Multivalency in Actin Networks
<p>The physical structure and dynamics of cells are supported by micron-scale actin networks with diverse geometries, protein compositions, and mechanical properties. These networks are composed of actin filaments and numerous actin binding proteins (ABPs), many of which engage multiple filaments …
-
Exploring multivalency and chemical modifications in the development of anti-PD-L1 peptide inhibitors for cancer immunotherapy
The PD-1/PD-L1 immune checkpoint axis is one of the most common pathways exploited by cancers to evade immune surveillance. Many cancers overexpress PD-L1 (programmed cell death ligand 1) on their surface through which they interact with PD-1 (programmed cell death protein 1) on activated immune …
-
Spatiotemporal Control of Actin Cytoskeletal Machinery in Cells: Multivalency Mediated Protein Clustering at the Plasma Membrane and Optogenetic Tool Development
… spatiotemporal control of actin assembly -- multivalency mediated phase separation and subcellular activation of actin polymerization machinery. The plasma membrane of the living cell is believed to function as a dynamic platform for signal transduction, rather than existing simply as a …
-
Exploring multivalent technologies and strategies for directed protein evolution
… abolish access to further phenotypic diversity. Multivalency is a strategy commonly applied by nature that has the potential to increase the strength of interaction and consequently the recovery and fitness of variants. As a result, this strategy may be able to support and tolerate mutations that …
-
Modelling multivalent interactons
… are weak. However, much more interestingly, multivalency enables the design of highly specific interactions using non-specific individual bonds. We attempt to rationalise multivalent effects using simple physical models complemented with numerical simulations. Based on physiochemical …
-
Facilitating Non-Covalent Interactions: 'Nanoglue' for DNA-CNT Nanohybrid Complexes
… in part due to covalent and self-assembled multivalency. Theory and observations gave cause for concern regarding the applicability of the ethidium bromide displacement DNA binding assay to systems containing polycyclic aromatic hydrocarbons, due to the possibility of intercalation into the …
-
Multivalent Supramolecular Systems
Nature uses multivalency as one of the most important governing principles to control selective molecular recognition and assembly. By combining a large number of weak interactions, it is possible to obtain high affinity, selective and reversible non-covalent binding processes. Multivalency has …
-
The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation with Arginine-Rich Nucleolar Proteins through Weak, Multivalent Electrostatic Interactions
… disordered region (IDR), confer additional multivalency and mediate interactions with proteins that contain multiple arginine-rich motifs (R-proteins). Using a variety of techniques, we have identified several nucleolar R-proteins which bind to and phase separate with NPM1. Here we show that …
-
Structually diverse Cu-64-labeled RGD peptide conjugates for PET imaging of αvβ3 expression
… of accomplishing higher binding affinity through multivalency has been pursued by evaluating the binding affinity of nanoparticles presenting multiple peptides on their surface. Copper radionuclides have been the subject of considerable research effort because they offer a varying range of …
-
Regulation of WASP in Actin Signaling: From Angstroms to Microns
… promoting actin assembly by the Arp2/3 complex. Multivalency is widespread from extracellular sugar binding proteins to transmembrane receptors to cytoplasmic adapters to nuclear chromatin. Multivalent interactions play a fundamental but incompletely understood role in biology. To assess its …
-
Design, Synthesis, And Testing Of Multivalent Compounds Targeted To Melanocortin Receptors
… detect, such as melanoma. We wish to apply the multivalency concept to differentiate between healthy cells and melanoma cells. Melanoma cells are known to over-express α-melanocyte stimulating hormone receptors. A successful multivalent construct should show greater avidity towards melanoma …
-
Regulation of Pumilio RNA Binding Proteins by Long Noncoding RNA NORAD
… liquid-like membraneless organelles through a multivalency-induced phase separation mechanism. Moreover, we provide a molecular understanding of the properties of NORAD that promote PUM phase separation, revealing new principles of lncRNA function and demonstrating the physiologic importance of …
-
Systems Materials Design of Ordered Nanocomposite Assemblies
… design dictates the thermodynamic strength and multivalency of nanoparticle superlattice assembly, enabling precise control of thermal stability, crystallographic symmetry, and collective bonding behaviors in massively multivalent systems. Building on these design principles, I develop a …
-
Male Prophets in Early Modern England, 1559-1662
… Grace Sujin Pak has recently highlighted the multivalency of early modern prophecy in a broad European context; her monograph identifies a broadening split between prophecy as scriptural exegesis and direct divine inspiration over the course of the sixteenth and seventeenth centuries. This …
-
Dendrimer Based Nanotherapeutics For Ocular Drug Delivery
… Their favorable properties such as small size, multivalency and water solubility can provide significant opportunities for many biologically unstable drugs and allows potentially favorable ocular biodistribution. This work exploits hydroxyl terminated dendrimers (G4-OH) as drug/gene delivery …
-
Engineering mono- and multi-valent inhibitors on a modular repeat-protein scaffold to target oncogenic Tankyrase
… and TNKS are multivalent, and the effects of multivalency were explored both in the test tube and in the cell. The results show that the proteins interact to form large assemblies. Moreover, the TBP-CTPR proteins were found to have exceptional activity in inhibiting the Wnt signaling pathway …
-
Unlocking precision medicine using DNA nanotechnology
… the concept could become the ideal testbed for multivalency, potentially paving the way to new computationally-designed affinity reagents.
-
Macromolecular design for modulation of amyloid fibrillar assembly
… Aβ aggregation. We investigated the influence of multivalency and specificity of molecular structures and optimized the Aβ modulatory effect by tuning molecular weights of polymers, as well as the loading ratio and the sequences of the attached Aβ recognition peptides. Chapter 4 describes the …
-
Controlling the Properties of Polymer Metal-Organic Frameworks and Cages Through Polymer Ligand Design
… and a coordination block with tunable multivalency for size control. This strategy produces uniform polyMOF-5 and polyUiO66 nanoparticles with sizes down to 20 nm, displaying exceptional structural and colloidal stability. Chapter 3: Radical PolyMOFs: A Role for Ligand Dispersity in …
-
The Synthesis of Amphiphilic Glycolipids as Potential Inhibitors of Bacterial Adhesion
… agents and immunomodulators. The concept of multivalency is also discussed, with specific examples relating to the anti-adhesion approach. A variety of O-glycolipids based around an aspartic acid scaffold were constructed in chapter 2. Based on a modular approach, a diverse range of …
Page 1 of 2