Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Multiple biomarkers"”.
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A covariate-adjusted classification model for multiple biomarkers in disease screening and diagnosis
… methods based on a linear combination of multiple biomarkers have been widely used to improve the accuracy in disease screening and diagnosis. However, it is seldom to include covariates such as gender and age at diagnosis into these classification procedures. It is known that biomarkers …
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Likelihood Ratio Combination of Multiple Biomarkers and Change Point Detection in Functional Time Series
Utilizing multiple biomarkers in medical research is crucial for the diagnostic accuracy of detecting diseases. An optimal method for combining these biomarkers is essential to maximize the Area Under the Receiver Operating Characteristic (ROC) Curve (AUC). The optimality of the likelihood ratio …
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Ketosis Suppression and Ageing (KetoSAge): Suppression of ketosis negatively affects multiple biomarkers associated with chronic diseases and ageing
… profile (metabolic phenotype) and changes in biomarkers associated with ageing and age associated diseases after suppressing ketosis (SuK) for 21 days, followed by a further investigation after removing the intervention of suppressing ketosis, with the participants reverting back to their …
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Classification Tree Models for Predicting Cancer Status
… of cancers might improve the clinical outcomes. Multiple biomarkers with a novel LabMAP technology were used as the laboratory method to develop the diagnostic assay for ovarian, breast, endometrial, and lung cancer. To evaluate the accuracy of early stage detection, logistic regression (with …
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Biomarkers of oxidative stress and inflammation in biological samples collected from recurrent airway obstruction (RAO)-affected horses and their controls
Multiple biomarkers of oxidative stress have been measured and used in human medicine to diagnose and monitor airway disease. The purpose of the study was to determine if similar relationships existed between inflammatory and oxidative stress biomarkers in exhaled breath condensate (EBC), …
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Development of fluorescent semi-conductor nanocrystal conjugates for in vitro and in vivo imaging applications
… mice. The ability to target single cells using multiple biomarkers and track them for the extended periods of time allowed us to study the microenvironment of the endogenous hematopoietic stem cells (HSCs), which was not possible using conventional techniques engaging dye conjugated antibodies. …
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Microfabricated Acoustic Sensors for the Detection of Biomolecules
… devices. Furthermore, they can be designed as multiplexed arrays to detect multiple biomarkers of interest in parallel. In order to develop a microfabricated biosensing platform, a specific and high affinity biodetection platform must be optimized, and the microfabricated sensors must be …
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Development of biomarker-based proxy methods for reconstructing the late Quaternary sea ice history in the Barents Sea
… methods (such as PIP25), and the availability of multiple HBIs characteristic of ice algal and pelagic production within sedimentary archives. This study investigated the potential of incorporating multiple biomarkers to characterise contrasting sea ice and productivity conditions in the …
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Multiplexed protein biomarker analysis on silicon photonic microring resonators: translation towards clinical diagnostics
Protein biomarkers are valuable indicators of human physiological states. In clinical practice, they play a strong role in presymptomatic diagnosis of various diseases, as well as evaluation of disease prognosis and aid in treatment decisions making. Due to the importance of biomarkers, much …
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Point of care platforms for protein and nucleic acid detection
… can detect pathogens, blood and serum-based biomarkers, and identify known disease markers. Many diagnostic systems developed to quantify cellular and proteomic take several hours and require sample purification before producing results. These delays in diagnostic capabilities greatly hinder …
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Development of liquid chromatography with tandem mass spectrometry method for measurement of sepsis biomarkers
… MS-based assay enables accurate measurement of biomarkers in serum and offers multiplexing capability. Measurements of biomarkers aid clinicians in their decision making and helps them to assess the efficacy of treatment. Hence, leading to improvement in the patient’s health and quality of life. …
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Screening of multi-omics biomarkers for Type 2 Diabetes Mellitus among Chinese population
… development and the development of predictive biomarkers for increased FPG level are crucial in Predictive, Preventive and Personalised medicine (PPPM) of T2DM. Established diagnostic tools for T2DM includes the oral glucose tolerance test (OGTT), fasting blood glucose (FBG) and glycated …
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Inflammatory response in maternal serum during preterm labour
… of the condition. PTB is a syndrome initiated by multiple mechanisms including infection or inflammation which is the only pathological process for which both a firm causal link with PTB has been established and a molecular pathophysiology defined. Intrauterine infection evokes an immune response …
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Generation and application of recombinant antibody fragments for prostate cancer detection.
… metastasising to different regions of the body. Multiple biomarkers in serum have been identified for the diagnosis of PCa. However, prostate-specific antigen (PSA) and its isoforms remain the gold standard test for PCa detection. Many antibodies have been generated for the detection of PSA with …