Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Multiple binding sites"”.
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A Statistical Model to Determine Multiple Binding Sites of a Transcription Factor on DNA Using ChIP-seq Data
… is a new technology that can reveal protein binding sites in genome with superior accuracy. Although many methods have been proposed to find binding sites for ChIP-seq data, they can find only one binding site within a short region of the genome. In this study we introduce a statistical model …
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A Mis-Expression Screen Identifies a PKA -Anchoring Protein in Antenna Lobe Development
… this gene. Akap200 is a Protein Kinase A (PKA) binding protein with multiple binding sites for other signaling molecules, including Protein Kinase C (PKC), Camodulin and F-actin. Further studies showed that ORN axons of the Akap200 mutants stall in the path to their targets. The loss of Akap200 …
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Investigations on the role of SLP-65 and other B cell signaling proteins in human leukemia
… mediated signal transduction. By providing multiple binding sites for other cellular effector molecules it assembles various proteins into one signaling complex. Therefore SLP-65 is involved in the control of different signaling pathways important for B cell development, survival and …
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A Network Approach to Understanding miRNA Regulation in Adipose Tissue
… in adipose tissue with an emphasis on miRNA binding activity. Most notably, we used Ago HITS-CLIP to comprehensively map mRNA:miRNA interactions in brown and white fat, revealing 21,281 unique miRNA binding sites in 6,717 genes. Most binding sites were shared between brown and white fat, …
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Statistical theory of selectivity and conductivity in narrow biological ion channels : studies of KcsA
… canonical ensemble for narrow channels with multiple binding sites and mixed-species bulk solutions; a derivation of the linear response theory of multi-species conduction in such channels; development of non-equilibrium multi-species kinetic equations, that describe the conductivity; the …
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Computer-Aided Design of Ligands at Multiple Protein Targets for Multifactorial Diseases
… to discover novel compounds active at multiple proteins/multiple binding sites including allosteric ligands. Calpain-1, a challenging target, was selected to develop and evaluate computational approaches to the discovery of novel ligands. Current selective calpain-1 inhibitors are …
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Dissecting the molecular role of distinct binding interfaces on the retinoblastoma tumor suppressor in growth control and tumorigenesis.
… These functions of pRB are mediated by distinct binding interfaces and their contributions to the overall functionality of pRB are not well defined. In this thesis multiple experimental approaches are employed to study the function of the distinct binding sites in isolation to better define their …
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Viral subversion of host cell membrane trafficking
… HDV genotypes revealed that HDV interacts with multiple binding sites on NTD promiscuously, prompting re-evaluation of the binding between cellular peptides and NTD. Surprisingly, co-crystal structures and pull-down capture assays showed that cellular peptides containing clathrin-binding motifs …
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Molecular and microscopical analysis of pathogenic streptococci - studies on surface proteins interacting with human cells and extracellular matrix
… (S. pneumoniae) with collagen type VI, the binding of S. pyogenes M1 protein and leucine rich (Slr) protein to collagen type I, and Slr’s interaction with human keratinocytes. The adherence of S. pyogenes and S. pneumoniae to collagen type VI in murine upper and lower airways was restricted …
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Applications of functional nucleic acids in imaging, sensing and drug delivery and investigations of DNAzyme-metal interactions
… reaction catalyzed by a DNAzyme/ribozyme or the binding event of an aptamer to a fluorescent, colorimetric or electrochemical signal. While a number of studies have been reported for in vitro sensing using DNAzymes or aptamers, there are few reports on in vivo sensing or imaging. MRI is a …
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Exploring Multiple Hydrogen Bonding and Ionic Bonding in the Design of Supramolecular Polymers
… and recyclability. Dynamic bonding with multiple binding sites, such as multiple hydrogen bonding or multiple ionic bonding, exhibits much stronger binding strength compared to the counterparts containing only a single binding site, thereby allowing for enhanced mechanical integrity to …