Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"Multiple Tissues"”.
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Translational defects in multiple tissues from the Smn2B/- mouse model of SMA.
… loss on translation in SMA mouse models across tissues, post-natal and pre-natal disease stages, focusing on both mild (Chapter 1) and severe forms of SMA (Chapter 2) respectively. To tackle this question, in this thesis, I took advantage of multiple cutting-edge and sequencing-based techniques …
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Genetic Constraints and the Evolution of Chemical Defenses in Multiple Tissues of Boechera stricta
… plants evolve defenses suited to different tissues and varying patterns of herbivory. If the defense profiles of different tissues share common genetic controls but differ in selective pressures, evolution of effective defenses within the whole plant may be constrained. In my dissertation, I …
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Annotating Human Interactome to Predict Pathways and Systematically Analyzing Network Rewiring in Cancer across Multiple Tissues
… primary cancer and normal samples across sixteen tissues and thirty-five cancer types. I used pairwise gene coexpression and differential coexpression to annotate 276,552 PPIs with tissue- and cancer-specificity. Pan-cancer comparison of annotated PPIs provides novel insights toward dynamics of …
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A multi-level approach of gene expression data analysis to investigate translatome dynamics across multiple tissues, stages, and mouse models of SMA
… in primary motor and cortical neurons, and in multiple tissues at the late stage of disease in the severe Taiwanese mouse model of SMA. Furthermore, SMN protein has been confirmed to be a ribosome-associated protein in vitro, in mouse cell lines and in vivo, and to physiologically regulate the …
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Epigenetic regulation of genes related to lipid metabolism by microrna in mice fed high fat diet
… hydrolysis and lipoprotein uptake in multiple tissues. A previous study reported that miR-29b negatively regulated LPL expression in mammary epithelial cells transfected with miR-29b mimics. The present study investigated changes in LPL expression and epigenetic mechanisms by the …
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The Role of Autophagy in Early Development and Tumor Suppression Using a Zebrafish Model System
… morphogenesis. Active autophagy was observed in multiple tissues during early embryonic development, as evidenced by the presence of autophagosomes in electron microscope images or GFP-LC3 puncta in autophagy reporter fish line Tg(cmv
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Large-scale inference and imputation for multi-tissue gene expression
Integrating molecular information across tissues and cell types is essential for understanding the coordinated biological mechanisms that drive disease and characterise homoeostasis. Effective multi-tissue omics integration promises a system-wide view of human physiology, with potential to shed …
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Genome-Wide Analysis of Transcription Factors Ascl1 and Ptf1a in Development and Cancer
… the same transcription factors can be found in multiple tissue types and are crucial for their development, and at other times these same factors can be misused in disease states. The basic helix-loop-helix (bHLH) factors Ascl1 and Ptf1a are examples of factors that give rise to and function in …
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Investigating 1500 Years of Dietary Change in the Lower Ica Valley, Peru Using an Isotopic Approach
… carbon and nitrogen isotopes. The combination of multiple tissues has allowed analysis at the intra-individual as well as the intra- and inter-group levels creating a detailed and nuanced dietary reconstruction that incorporates dietary information about childhood, adulthood and over a short-term …
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Differential expression of small RNAs in soybean
… RNA isolation and blotting. Purified RNAs from multiple tissues such as immature seed coats and cotyledons, germinated cotyledons, unifoliates, shoot tips, stems, and roots were used to examine differential expression. The RNA blots were probed with the 5’ end-labeled oligonucleotides that would …
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Functional genomics of developmental disorders
… scientific centres and can be generated across multiple tissues. Lastly, I compare DNA methylation signatures generated from methylation microarrays to those generated from genome-wide long read sequencing data, and provide evidence that long read sequencing is a reliable and scalable method to …
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Regulation and function of histone variant H2BE in neurons
… histone proteins affects gene expression through multiple mechanisms, including exchange with histone variants. While variants of H2A and H3 have well defined roles in chromatin regulation, widely expressed variants of H2B remain elusive. Further, while recent findings link histone variants to …
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MULTI-ORGAN FAILURE DRIVEN BY TELOMERE UNCAPPING
… level. Trf2 deletion was rapidly achieved across multiple tissues and this event was accompanied by DDR activation and multi-organ functional failure, ultimately leading to lethality within approximately one week. Trf2 knockout elicited a syndrome resembling that occurring upon exposure to high …
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INVESTIGATING THE ROLE OF LIPID DROPLETS AS INTRACELLULAR MECHANICAL STRESSORS IN NON-ALCOHOLIC FATTY LIVER DISEASE
… been linked to disease and cancer development in multiple tissues, including the liver, where cirrhosis (which increases stiffness markedly) is the major risk factor for hepatocellular carcinoma (HCC). Stiffness is correlated with cancer development and patient prognosis, and is used clinically in …
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Analysis of enzymatic L/D-peptide isomerization in animals
… Furthermore, isomerase activity was detected in multiple tissues in the rat, and a mammalian neuropeptide was found to be isomerized by this activity. These findings advance our understanding of the extent and function of enzymatic L/D-peptide isomerization as a PTM in bioactive peptides.
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The effect of brain-specific VEGF-C deletion on vascular morphology in the brain and skull
… effects on the blood vasculature in the analyzed tissues. However, male mice with Vegfc deletion displayed mLV hypoplasia, which was more severe than in females, and they also had swollen paws. Further immunofluorescence analysis of the ears, genotyping of the toes and qPCR analysis of Vegfc …
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A Novel Role for HAPLN1 in Skeletal Development
… hyaluronic acid (HA) and proteoglycans in multiple tissues. One variant, p.C304S, was predicted to disrupt a critical disulfide bridge of the HAPLN1 C-terminal loop domain. In transient over-expression experiments, we detected wild type mouse Hapln1 protein in the cell lysate, media, and …
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Generation of a human gene index and its application to disease candidacy
… data because one gene can be expressed in multiple tissues, with the result that multiple tissue partitioned transcripts will correspond to the same gene.Therefore, the sequence data represented by each tissue category had to be merged in order to obtain a comprehensive view of expressed …
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Development of A Gene Therapy for Creatine Transporter Deficiency
… resulting in a depletion of creatine in multiple tissues, including the brain. Symptoms include intellectual disability, developmental delays, hyperactivity, and motor function deficits. As creatine is unable to cross cell membranes, supplementation is ineffective, and there are no …
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Mathematical Models of Major Arterial Occlusion
… the effects of major arterial occlusion in multiple tissues and vascular geometries. A network representing the vasculature of the rat hindlimb is used to study peripheral arterial disease characterized by femoral artery occlusion. This work couples responses that occur on different time …
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