Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 477 for “"Multiple Sclerosis"”.
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Metabolomic characterization of Multiple Sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system with a strong autoimmune component. MS is the most common cause of non-traumatic acquired neurological disability in young adults with a particularly high incidence in Sardinia. Several aspects still represent …
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Imaging and therapy in multiple sclerosis
Multiple sclerosis (MS) is a common, debilitating autoimmune disorder of the central nervous system (CNS). The most visible element of MS pathology is white matter (WM) lesions. However, extra-lesional abnormalities are recognised and appear most marked at the outer (subpial) brain surfaces at …
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Tobacco Smoke Exposure and Pediatric Multiple Sclerosis
Introduction: Multiple sclerosis (MS) is a chronic inflammatory disease which affects approximately 2.5 million people worldwide, including approximately 7,000 children. The etiology of MS is unclear, although researchers generally agree that both environmental and genetic factors are involved. It …
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Gait variability in persons with multiple sclerosis
… examining gait variability in people with multiple sclerosis (MS), which is a neurological disease that can result in significant walking impairment. Gait variability, i.e. fluctuations in the mechanics and kinematics of steps during walking, has been associated with motor control function, …
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Human herpesvirus 6 in multiple sclerosis and encephalitis
… nervous system (CNS) such as encephalitis and multiple sclerosis (MS). The present studies were aimed to elucidate the role of HHV-6 and its two variants in neurological infections. Special attention was given to study the possible role of HHV-6 in the pathogenesis of MS. We studied the …
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Engagement in occupations in persons with Multiple Sclerosis
… of engagement in occupations in persons with Multiple Sclerosis (MS) in order to develop client-centred occupational therapy and rehabilitation. In study I, observations of the performance of self-care and household occupations were pursued in 44 participants, and study II identified …
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Lipid Metabolism in Mild to Moderate Multiple Sclerosis
Objective: The purpose of this study was to assess lipid metabolism in persons with mild to moderate MS through an examination of dyslipidemia. Plasma concentrations of PCSK9 and its potential correlation between LDL-C. Methods: A case-controlled design was used to access potential differences in …
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Dysphagia patient-reported outcome measures in multiple sclerosis
Dysphagia in multiple sclerosis (MS) is poorly characterized. The Dysphagia in Multiple Sclerosis (DYMUS) is a dysphagia questionnaire developed specifically for persons with MS but lacks validation, and recent research has questioned its accuracy as a screening tool. The Sydney Swallow …
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Exploring retinal changes in Dementia and Multiple Sclerosis
… in Alzheimer`s disease (AD) and disability in Multiple Sclerosis (MS). Detection of molecular and morphological hallmarks in the brain or spinal cord is invasive, insensitive and expensive. It has been hypothesized that changes in the retina may mirror changes in the brain. In contrast to brain …
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Differential regulation of cytokine secretion in multiple sclerosis
Multiple sclerosis (MS) is the most common autoimmune inflammatory demyelinating disorder of the human nervous system affecting nearly 1 million people worldwide every year. Current treatments for first-line nontoxic therapy of the relapsing-remitting form of the disease are two forms of …
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Physical fitness and cardiovascular function in multiple sclerosis
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease that affects the central nervous system. Cardiovascular function (CV) has been shown to be impaired in persons with MS which can lead to the development of comorbidities that can promote disability progression. …
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Humanized Chimeric Receptors in the Therapy of Multiple Sclerosis
… encephalomyelitis, the murine model of multiple sclerosis. We here demonstrate the ability of humanized chimeric receptors to suppress experimental autoimmune encephalomyelitis (EAE) in a humanized mouse model by redirecting T lymphocytes against autoreactive T-cells. The receptors were …
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Development of Novel Small-Molecule Therapeutics for Multiple Sclerosis
Protein arginine deiminase (PAD) activity is upregulated in MS and the overactive enzymes convert peptidyl arginine on myelin structural proteins to neutral citrulline variants. Hypercitrullination disrupts key ionic interactions between myelin proteins and lipid bilayers that are necessary to …
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Cognitive Correlates Of Fatigue In Pediatric-Onset Multiple Sclerosis
Fatigue is common in pediatric-onset multiple sclerosis (POMS), yet causal factors and correlates of fatigue are poorly understood in this population. A systematic review of fatigue and cognition was conducted in Chapter 2. The available evidence confirms that fatigue is a common symptom in POMS …
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Factors and processes involved in adjustment to multiple sclerosis
Multiple sclerosis (MS) creates numerous ongoing challenges which, for some, result in negative outcomes such as depression, poor quality of life, and impaired functioning. This thesis aimed to investigate the nature of psychological adjustment to MS and elucidate factors that interventions could …
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