Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Multiple Drug Resistance"”.
-
Korrelation von in vivo-Resistenz gegen Chloroquin mit allelischen Polymorphismen bei Plasmodium falciparum-Isolaten aus Uganda
… von Tumorzellen im Rahmen der so genannten „multiple drug resistance“. Das Auftreten von bestimmten Punktmutationen im sog. Plasmodium falciparum multiple drug resistance Gen 1 (Pfmdr1 auf Chromosom 5), das für das Efflux-Protein kodieren könnte, ist mit Chloroquinresistenz assoziiert worden …
-
The discovery and bioactivity evaluation of a novel peptide, QUB-1925, and its modified analogue, QUB-2067, from the defensive skin secretion of the frog, Phyllomedusa coelestis
… being or providing lead compounds in the future drug development. Those frog skin antimicrobial peptides with potent activities against a broad range of microorganisms are of highest potential, due to the emergence of the multiple drug resistance issue of conventional antibiotics.<br/>In this …
-
Computational methods for transport properties
Through antimicrobial resistance many bacteria can survive to an ever larger number of antibiotics. This is true in particular for a category of bacteria classified as gram–negative. These kinds of bacteria differ from the other ones by the presence of an outer membrane, which is able to protect …
-
A feasibility study of chemosensitivity testing in primary cultures from malignant gliomas, and analysis of drug resistance mechanisms
… response is limited by the development of drug resistance. A study was undertaken to investigate the feasibility of providing information about tumour chemosensitivity in vitro by culturing glioma tumour cells in a hospital setting and performing chemnosensitivity assays on them using five …
-
Single-molecule visualization of conformational changes in the SecA ATPase
… is great as bacterial strains with single and multiple drug resistance have continued to grow more prevalent since the 1980's. At the same time, the rate of approval of new antibiotics has dropped precipitously. Existing antibiotics commonly target the bacterial ribosome. A or cell wall …
-
Expression profile of multidrug resistance genes and proteins in cancerous and stem cells
… cells and discover their association with multidrug resistance (MDR) related genes, i.e. multiple drug resistance I (mdrl) gene and anti-apoptotic gene (bcl-2) in human glioma compared to normal brain tissues and cell lines. Glioma and normal astrocyte cell lines have been employed for CD133 …
-
Meta-analysis of the population and phenotypic expression of CYP2C9/2C19 polymorphism on drug metabolism in different ethnicities
… study of inherited factors that affect the human drug response. Many pharmacogenetie studies have been published since 1995 and have focussed on the principal enzyme family involved in drug metabolism, the cytochrome P450 family, particularly cytochrome P4502C9 and 2C19. In order to investigate …
-
4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
<p>The development of multidrug resistance in tumor cells has been recognized as a major obstacle to successful cancer treatment. Tumor cells in vitro and in vivo can develop multidrug resistance (MDR) to the lethal effects of a variety of cytotoxic drugs used to treat cancerous tumor cells. The …
-
4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
<p>The development of multidrug resistance in tumor cells has been recognized as a major obstacle to successful cancer treatment. Tumor cells in vitro and in vivo can develop multidrug resistance (MDR) to the lethal effects of a variety of cytotoxic drugs used to treat cancerous tumor cells. The …
-
NEW PREDICTIVE FACTORS IDENTIFIED BY MOLECULAR STUDY IN CHEMORESISTANT HUMAN AND CANINE MAMMARY CARCINOMA CELLS
… is discussed as an adjuvant treatment. However, resistance to treatment is a challenge and may be related to acquired or pre-existing genetic mechanisms in tumors. Genetic mutations, such as the presence of SNPs and CNVs in DNA and miRNAs dysregulation can be involved in CMTs and BC resistance. …
-
Potentiation of drug-induced cytotoxicity by conjugated linoleic acids (CLA) in in vitro models of drug-resistant cancer
… of their potential benefits in targeting drug-resistant cancer cells. Additionally, several lines of evidence implicate a role for sphingolipids in multiple drug resistance. The objective of this study was to evaluate the effects of conjugated linoleic acids (CLA) and various anticancer …
-
Discovery of Novel Tubulin Polymerization Inhibitors and Survivin Inhibitors as Potential Anticancer Agents
… many problems associated with current therapies. Drug resistance to targeted therapies is almost inevitable after short term treatment. Immunotherapies generally have low response rate and the effects vary among patients. Therefore, the need to develop new and more effective treatment for melanoma …
-
The Membrane as a barrier or target in cancer chemotherapy
… the cell membrane as a barrier and/or target for drug action and relate this to the development of strategies for overcoming multiple drug resistance (MDR). The effects of doxorubicin on various bacterial strains expressing different levels of anionic phospholipid were compared. Giowth of …
-
RNA Interference for Improving the Outcome of Islet Transplantation and Polymeric Micelle‑based Nanomedicine for Cancer Therapy
… cell proliferation and was able to circumvent multiple drug resistance (MDR) in cancer cells. SMART‑100 inhibited P‑gp activity, which may be responsible for its ability to overcome MDR. Since SMART‑100 is poorly soluble in water, it was formulated in poly(ethylene glycol)‑b‑poly(D, L‑lactide) …
-
Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents
… often has low therapeutic index and encounters drug resistance shortly after initiation, while immunotherapies exhibit low response rates that vary between patients. As a result, there is a pressing need for the development of novel and effective cancer treatment. The work presented here focuses …
-
“Green” synthetic methodologies for the fabrication of gold nanostructures with photothermal properties for multi-responsive therapies [Metodologie sintetiche “ Verdi” per la fabbricazione di nanostrutture d'oro con proprietà fototermiche per terapie multi-reattive]
Il basso tasso di ricambio dei nuovi farmaci, unito alla resistenza multipla dei farmaci da parte delle cellule tumorali e dei batteri, rende necessaria la ricerca di nuovi approcci terapeutici. Le terapie fototermiche (PTT) e fotodinamiche (PDT), basate sul rilascio foto-controllato di calore e …