Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Multinucleation"”.
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Regulatory Mechanisms of Mitotic Catastrophe Induced by Doxorubicin
… of doxorubicin-induced mitotic catastrophe (or multinucleation) to understand the regulatory mechanisms of mitotic catastrophe in human colorectal carcinoma cells. MATERIALS AND METHODS: We used human hepatoma (Huh-7) and human hepatocellular carcinoma cell lines (SNU-354, -398, -449, and -475) …
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Étude de l’expression et du rôle du ligand du co-stimulateur inductible des cellules T (ICOSL) dans les ostéoclastes humains
… in human osteoclasts, and its impact on multinucleation and bone resorption, two phenotypic features of these cells. We were able to demonstrate ICOSL expression in our model of fetal monocyte-derived osteoclasts in long-term culture. Inhibition of ICOSL expression by DsiRNA resulted in a …
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Sublethal Hepatic Pathology and Evidence of Intranuclear Effects of the Cyanobacterial Toxin Microcystin -Lr
… induced hepatocytomegaly and karyomegaly with multinucleation. Hepatocyte nuclei were strongly labeled by MCLR-IHC, 4 hours after one sublethal dose. Western blotting confirmed the presence of toxin in the nucleus bound to protein phosphatases 1 and 2A. Nuclear phosphatase activity of mice …
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Homology-Directed Repair of Dna Lesions Generated by the Mismatch Repair Dependent Processing of Cytotoxic Guanine Adducts
… formation of radial chromosomes, aneuploidy and multinucleation. This study suggests that HR-insufficiency would likely present a risk factor for the development of secondary cancers resulting from methylating chemotherapeutic and thiopurine treatment. Therefore, the novel findings presented here …
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Significance of Altered Golgi Apparatus and Cell Fusion Events in Ovarian Cancer Cells
… for transcription adapter-3 (TADA3)-mediated multinucleation has been suggested. Treatment of ovarian cancer cells with cisplatin resulted in significant fragmentation of the Golgi apparatus with cisplatin-induced Golgi fragmentation detected before cisplatin-induced DNA damage. Inhibition of …
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An investigation of mutant p53 function.
… to influence mitotic pathways, resulting in multinucleation, and enhance the invasive and migratory properties of cancer cells. Importantly, an endogenous protein, ANKRD11, is identified with the capacity to suppress the oncogenic properties of mutant p53 and provide a potential target for …
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Multinuclear and Mononuclear Polyploidy in the Drosophila Hindgut and Heart
<p>A fundamental question of biology is how tissues are organized. Tissues can be composed of many small cells or comparatively fewer large cells that add nuclear content to facilitate tissue growth. The cells can be separate, discrete units or interconnected collectives. The nuclear composition of …