Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Multimodal imaging"”.
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Synaptic Multimodal Imaging and Molecular Network Inference
… previously developed probe exchange multiprotein imaging technique, this thesis presents MINI-ME, a versatile, modular platform for integrating multiple information modalities at single synapses. We developed an approach for tandem live-fixed imaging to combine synaptic calcium dynamics or …
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Multimodal imaging monitoring of key physiological changes of peripheral arterial disease
… “landmarks.” To define these landmarks, we use a multimodal imaging approach starting with Laser Speckle Contrast Imaging (LSCI) and Power Doppler ultrasound for perfusion (superficial and deep tissue, respectively); followed by fluorescent imaging of hypoxia and imaging both angiogenesis and …
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Multimodal Imaging of Inflammation at the Neurovascular Interface in Cerebrovascular Disease
… stroke. While conventional clinical imaging simply measures the degree of vessel stenosis, it is a crude measure that reveals little of the metabolic processes affecting plaque vulnerability. Our research demonstrates the utility of positron emission tomography (PET) using …
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Remembering the past : multimodal imaging of cortical contributions to episodic retrieval
… arising from the recovery processes. A multimodal imaging approach that combined fMRI and MEG was adopted to gain insight into the spatial and temporal brain mechanisms supporting episodic retrieval. Chapter 1 reviews major findings and theories in the episodic retrieval literature …
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Multimodal Imaging Documentation in Dental Medicine // Мултимодално образно документиране в денталната медицина
… perhaps the most innovative invention in dental imaging diagnostics. This modality not only conducts comprehensive radiographic analysis but also allows us to generate 3D models. Data on the application, advantages, and limitations of models generated this way are still extremely limited and …
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Identification of Image-based Markers for Oral Pre-cancers and Cancers using in-vivo Multimodal Imaging
… in cancer, providing in-vivo three-dimensional imaging with contrast from endogenous fluorophores, including tissue metabolites, NADH and FAD. Features revealed by NLOM have shown to parallel histopathology, however, studies are few and have focused on epithelial cells or stromal collagen but …
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Targeting the receptor for advanced glycation end products with a quantitative multimodal imaging method for precision medicine
… suggesting its promise as a molecular target for imaging and therapeutics. In this work, we developed and employed a nanoparticle-based imaging strategy of RAGE, first in a model of hind-limb ischemia (a widely-studied pathological model for RAGE signaling), and subsequently in PCa. Finally, we …
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Responsive, multimodal imaging agents for MRI: advancing the detection of metals and oxidized species implicated in neurodegenerative disorders
The successful development of responsive, multimodal imaging agents required a bottom-up approach starting with the nature of the iron oxide nanoparticles. Thee relaxivity of the nanoparticles was found to be dependent on the total anisotropy of the particles themselves, which is in turn a function …
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Multimodal Imaging of Protein-Based Biomaterials for Delivering Chemo-Agent Cargo for Glioblastoma Treatment in a Murine Model
… across treatment groups, with bimodal in vivo imaging employed for evaluation. Bioluminescence imaging (BLI) tracked tumor cell activity and progression, while magnetic resonance imaging (MRI) measured end-stage tumor volume.</p> <p>Preliminary results indicated that F-TRAP-DOX exhibited …
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A Framework for 3D Mouse Brain Reconstruction: RNA-based Stitching of Adjacent Tissue Slices and Co-Registration of Multimodal Imaging Data
… methods for co-transforming fluorescent protein imaging data were explored to fully resolve the cell boundaries between neurons. These three methods are necessary steps towards creating a fully-resolved, multimodal 3D model of the brain.
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Developing Single-Laser Sources for Multimodal Coherent Anti-Stokes Raman Scattering Microscopy
… applications. It is specifically focused on multimodal nonlinear optical microscopy—the simultaneous combination of different imaging techniques. This allows us to address a diverse range of applications, such as the study of biomaterials, fluid inclusions, atherosclerosis, hepatitis C …
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Joint CT-MRI Image Reconstruction
… have been increasingly reliant on medical imaging techniques. In return, medical images are required to provide more accurate and detailed information than ever. Aside from the evolution of hardware and software, multimodal imaging techniques offer a promising solution to produce higher …
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Structural and functional characteristics of meibomian glands in meibomian gland dysfunction
… disease (DED). The third prospective study used multimodal imaging to evaluate MG orifices and explore their associations with, and ability to predict symptoms. The fourth study investigated inter-day and intersubject variations in meibum lipid and protein profile, and the fifth study …
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Lesion identification and the effect of lesion on motor mapping after stroke
… that includes longitudinal behavioral and multimodal imaging data in both stroke patients and healthy controls for two research projects. Firstly, I improved an automatic lesion segmentation method to aid in the identification of the location and extent of the stroke in structural magnetic …
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Enhancement and wavelength-shifted emission of Cerenkov luminescence using multifunctional microspheres
… microspheres for Cerenkov luminescence imaging and targeting of angiogenesis in cancer and atherosclerosis. Cerenkov luminescence imaging has gained attention as a new type of molecular imaging modality for its potential to bridge optical imaging with nuclear imaging. The engineered …
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Time-of-Flight Secondary Ion Mass Spectrometry Analysis of Microbial Induced Corrosion of Glasses
… (ToF–SIMS) – a powerful mass spectral imaging technique with high surface sensitivity, mass resolution, and mass accuracy – is used to study biofilm effects on different substrates. The first study examined the stress response of a biofilm to low carbon source media and suggested that …
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Understanding The Physics Of Magnetic Nanoparticles And Their Applications In The Biomedical Field
… these materials as candidates in medical imaging. Taken together, these studies have advanced our understanding of the fundamental physical principles that governs magnetism in magnetic materials with a focus on developing these nanoparticles for advanced biomedical applications. The …
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