Global ETD Search
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Showing 1 to 7 of 7 for “"Multidrug-Resistance Transporter"”.
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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
<p>The development of multidrug resistance in tumor cells has been recognized as a major obstacle to successful cancer treatment. Tumor cells in vitro and in vivo can develop multidrug resistance (MDR) to the lethal effects of a variety of cytotoxic drugs used to treat cancerous tumor cells. The …
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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
<p>The development of multidrug resistance in tumor cells has been recognized as a major obstacle to successful cancer treatment. Tumor cells in vitro and in vivo can develop multidrug resistance (MDR) to the lethal effects of a variety of cytotoxic drugs used to treat cancerous tumor cells. The …
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Broad Ligand Specificity in the Small Multidrug Resistance Transporter EmrE
<p>EmrE, an <italic>E. coli</italic> small multidrug resistance transporter, effluxes a diverse range of toxic polyaromatic cations, thus imparting resistance to drug compounds of this type. Transporters must interconvert between inward- and outward-facing structures during the transport cycle to …
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The Evaluation of Conserved Amino Acids that Influence Polysubstrate Specificity in the Multidrug Resistance Transporter, EmrE
… mechanism of substrate recognition/binding by multidrug resistance transporters has taken different approaches. I have utilized a PCR-driven site-directed mutagenesis analysis to alter conserved amino acid residues within the Escherichia coli small multidrug transporter, EmrE. The EmrE variants …
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Investigations into the Lipid Transport Mechanisms and Energetics of Bacterial ATP-Binding Cassette (ABC) Transporters MsbA and LmrA
LmrA and MsbA are two paradigms in research on multidrug ATP-binding cassette (ABC) transporters. The bacterial transmembrane protein LmrA from *Lactococcus lactis* was the first known prokaryotic ABC transporter homologue of the mammalian multidrug resistance transporter ABCB1 (P-glycoprotein) …
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Novel Determinants That Influence Azole Susceptibility in Candida glabrata and Candida albicans
… </em>infections, expresses high rates of resistance to treatment with arguably the best class of currently available antifungals - the azoles.</p> <p>Other available antifungals have associated toxicities, are not available as oral dosage forms or are cost prohibitive. As multidrug …
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Mechanism of Action Studies of Phenotypic Whole-cell Active Antimalarial Leads Through Target Identification
… tools for mode of action studies. In vitro resistance selections represent one of the genomics tools for target deconvolution of hit and lead molecules. The mechanism of resistance of the pyrido[1,2- a]benzimidazoles was investigated through resistance selection. Whole-genome sequencing of …