Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Multidrug transporters"”.
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Energetics and Structural Aspects of Cation-Coupled Drug Transport by NorM Multidrug Transporters
NorM multidrug transport proteins belong to the multiple antibiotics and toxins extrusion (MATE) family of secondary active transporters. Members of this family are present across all species including bacteria, plants and humans. In bacteria, their over-expression can lead to antibiotic …
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Structural and Functional Analysis of Substrate Recognition and Inhibition of the Multidrug Transporters MRP1 and MRP2
… disease is less than 50%. Overexpression of multidrug resistance protein 1 (MRP1), a plasma membrane ATP-binding cassette (ABC) transporter, is associated with high-risk neuroblastoma. While it is known that MRP1 transports multiple neuroblastoma chemotherapeutic agents out of the cell in a …
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Mechanistic insights into the secondary-active multidrug transporter LmrP
… mechanisms is active drug extrusion by bacterial multidrug transporters. LmrP is a Major Facilitator Superfamily (MFS) multidrug transporter which, when overexpressed in bacteria, can confer resistance to 22 clinically important antibiotics. The structural data for MFS proteins support an …
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Energetics and mechanisms of substrate transport by the MATE transporter PfMATE
Multidrug resistance of microbial pathogens and cancers is a significant global challenge, imposing substantial economic and social burdens. Organisms ranging from bacteria to mammals can develop resistance to previously effective drugs, which compromises the therapeutic outcomes. The misuse and …
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Investigating the function of the multidrug transporter ABCG2
… alone is traditionally thought to drive ABC transporters, but recent research shows that a transmembrane chemical proton gradient (ΔpH) contributes in certain bacterial ABC multidrug transporters. Therefore, this work aimed to elucidate the effect of ΔpH on ABCG2-mediated transport. First, …
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Novel Strategies towards the Inhibition of ATP-Binding Cassette (ABC) Transporters from Pathogenic Bacteria
Multidrug transporters in the ATP-Binding Cassette (ABC) superfamily play critical roles in pathogenic bacteria. These transport systems are particularly important in conferring antibiotic resistance on the cell by mediating the efflux of a wide range of structurally unrelated compounds and the …
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Deciphering Multidrug Efflux: Substrate Interactions and Transport Mechanisms in PatAB and NorM-VC
Multidrug efflux transporters are ubiquitously expressed in all kingdoms of life. In bacteria, they participate in several innate physiological functions to aid survival and adaptation. Given their crucial roles in conferring antimicrobial resistance (AMR), the understanding of the structural and …
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On the Structure and Function of Multidrug Efflux Pumps
Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic …