Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Multidrug resistance (MDR)"”.
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Štúdium modulácie cytostatickej rezistencie pomocou vybraných cielených protinádorových liečiv
… thesis: Study of modulation of cytostatic resistance using selected targeted anticancer drugs Cancer diseases rank among the most common causes of death, with increasing prevalence and incidence. The effectiveness of anticancer therapy is often diminished by multidrug resistance (MDR), …
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Comparison of the effect of acetylated polyamines and N⁸-acetylspermidine deacetylase inhibitor, APAH, on LS180 and multidrug resistant cells
<p>Multidrug resistance (MDR) is a major obstacle of current chemotherapy. In this study, we investigated the effects ofpolyamines, acetylated polyamines and APAH, a polyamine deacetylase inhibitor, on LS180 cells and the derived MDR LS180 Ad-50 cells. L.ethal concentrations for 20% of the cells …
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Semi-synthesis and evaluation of fusidic acid derivatives as potential antituberculosis agents
… Although TB is curable, the ability to acquire resistance to various antibiotics by the Mtb organism is well known. The emergence and spread of multidrug resistance (MDR) and extremely drug resistance (XDR) Mtb strains, along with HIV/TB co-infections, has put TB control programmes in jeopardy, …
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Purification and characterisation of the Escherichia coli multidrug efflux protein MdtM
Multidrug resistance (MDR) is the simultaneous acquisition of resistance by bacteria to a broad spectrum of structurally dissimilar compounds to which they have not been previously exposed. The principle cause of MDR has been identified as the efflux of antimicrobials from the cell by proteins …
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Mechanisms of multidrug resistance in bladder cancer: the role of the nuclear membrane
Multidrug resistance (MDR) describes the phenomenon whereby cancer cells<br/>exposed to a single cytotoxic drug develop cross resistance to numerous other<br/>structurally unrelated chemotherapeutics. The development of MDR is a major<br/>cause of cancer chemotherapy treatment failure in all types …
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Development of novel strategies to combat multidrug resistance mediated by efflux transporters and intracellular bacteria
<p>Multidrug resistance (MDR) is the condition where cancer cells or microorganisms cease to respond to multiple drugs. MDR conferred by efflux transporters, that deprive the bioavailability of drugs at their site of action, are a threat to cancer and malarial chemotherapy. Specifically, the …
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Structural mechanism for multidrug efflux systems
… toxic chemicals and mediate a phenomenon of multidrug resistance (MDR) in bacteria. The expression of these efflux transporters is tightly controlled at the transcriptional level by transcriptional regulators. A number of these transcriptional regulators are also multidrug binding proteins, …
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The Relationship Between Biofilm Production and Human Respiratory Cell Attachment and Invasion by Acinetobacter Baumannii
… that often lead to septicemia. Increasing multidrug resistance (MDR) in <em>A. baumannii</em> warrants new approaches to understanding its virulence mechanisms and pathogenicity. As a first step in infection, <em>A. baumannii</em> can attach to host cells, providing a surface for the …
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Characterization of P-glycoprotein expression as a multixenobiotic resistance mechanism in fish
… P-glycoproteins (P-gps) are responsible for multidrug resistance (MDR) phenotypes in tumor cell lines. P-glycoproteins function as energy dependent efflux flippases that prevent the cellular accumulation of a wide variety of compounds. We characterized P-gp expression in populations of …
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Isolation and characterization of a common nuclear matrix protein and other studies
… could play an important role(s) in mitosis. Multidrug resistance (MDR) was also investigated in various human and rat prostate cancer cell lines. The majority of the cell lines analyzed did express an increased MDR phenotype when compared to the MDR negative controls. Two rat prostate cell …
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Mobilome and antibiotic resistance in Acinetobacter baumannii
… infections with a remarkable ability to develop resistance to multiple antibiotics (multidrug-resistance, MDR) which makes it a highly troublesome pathogen in many hospitals around the world. Third-generation cephalosporins (such as ceftazidime) and carbapenems (such as imipenem and meropenem) …
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Understanding the intrinsic antibiotic resistance in Lysobacter enzymogenes, a ubiquitous environmental bacterium
… be resistant to many antibiotics, resulting in multidrug resistance (MDR). Increased understanding of antibiotic resistance in environmental bacteria provides new targets for discovery of novel therapeutics. However, little is known about the antibiotic resistance of the vast majority of …
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Identification and Development of Novel Compounds for the Treatment of Human Cancers
… prevent unraveling of the G-quadruplex.Because resistance to chemotherapy reduces its effectiveness, development of multidrug resistance (MDR) modulators was also studied. Psorospermin is a topoisomerase II-directed DNA alkylating agent active against MDR cell lines. In a study examining the …
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Targeting infectious species by Structure-guided Fragment-based Drug Discovery and in silico approach
… in which several human pathogens have developed multidrug resistance and few new antibiotics are being discovered. In addition to the challenge of the emergence of antibiotic resistance, the bacterial population also harbours mechanisms that increase pathogenicity and virulence by tolerating …
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Expression profile of multidrug resistance genes and proteins in cancerous and stem cells
… cells and discover their association with multidrug resistance (MDR) related genes, i.e. multiple drug resistance I (mdrl) gene and anti-apoptotic gene (bcl-2) in human glioma compared to normal brain tissues and cell lines. Glioma and normal astrocyte cell lines have been employed for …
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In vitro studies on the cellular mechanisms of resistance to cytotoxic compounds with special reference to multidrug resistance and cancer chemotherapy
The development of resistance to antineoplastic drugs is a major obstacle in the treatment of cancer. When resistance develops to natural product, lipophilic antitumour agents the resistance is also conferred to structurally and functionally unrelated compounds. This phenomenon is termed multidrug …
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Molecular Rationale Behind the Differential Substrate Specificity of Homologous RND Transporters in E. coli and P. aeruginosa
… them out of the cells, thereby contributing to multidrug resistance (MDR). Resistance-Nodulation-Division (RND) transporters like AcrB and AcrD in Escherichia coli, and MexB and MexY in Pseudomonas aeruginosa are the most prominent multi-component drug efflux pumps exporting a wide range of …
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Ritonavir - A Novel Multidrug Resistance Modulator in Cancer Chemotherapy and Ocular Neovascular Diseases
Multidrug resistance (MDR), a clinical outcome characterized by subtherapeutic intracellular drug concentration, is one of the predominant factors limiting effective cancer chemotherapy. Several possible mechanisms and molecular alterations have been implicated in the development of MDR, including …
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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
<p>The development of multidrug resistance in tumor cells has been recognized as a major obstacle to successful cancer treatment. Tumor cells in vitro and in vivo can develop multidrug resistance (MDR) to the lethal effects of a variety of cytotoxic drugs used to treat cancerous tumor cells. The …
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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
<p>The development of multidrug resistance in tumor cells has been recognized as a major obstacle to successful cancer treatment. Tumor cells in vitro and in vivo can develop multidrug resistance (MDR) to the lethal effects of a variety of cytotoxic drugs used to treat cancerous tumor cells. The …
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