Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Multidomain protein"”.
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Conformational changes in actinin-type actin binding domains: probing actin-induced structural dynamics in dystrophin and utrophin using EPR spectroscopy.
… is a lack of functional dystrophin, a large multidomain protein. Dystrophin is normally expressed in muscle, where it links the extracellular matrix to the cortical actin cytoskeleton via a complex of associated proteins. Dystrophin, and its autosomal homologue utrophin, connect with the …
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Axon guidance in the zebrafish visual system: Analysis of Esrom Mutant
… to be an orthologue of PAM/Hiw/RPM-1. This large multidomain protein has an E3 ligase activity. Esrom is ubiquitously expressed in the embryo. RGCs require it for proper activation of p38 signal transduction pathway in response to lysophosphatydic acid (LPA). Esrom is also known to regulate …
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Design and development of a site specific protein patterning technique for use in a microfluidic antibody separation device
… surfaces presenting multiple micron scale protein motifs, for integration within a microfluidic channel device, is described in this thesis. <br/><br/>Initial research focussed on conjugating protein motifs on silicon <100> substrates in micron and submicron scale patterns. A method …
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The Structural and Functional Study of GIT1 Paxillin Binding Domain
<p>The G protein coupled receptor (GPCR)-kinase (GRK) interacting protein 1 (GIT1) is a multidomain protein that plays an important role in cell adhesion, motility, cytoskeletal remodeling, and membrane trafficking. GIT1 mediates the localization of p21-activated kinase (PAK) and PAK-interactive …
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In vitro reconstitution of the human pre-mRNA 3′ end processing machinery and mechanistic insights into endonuclease activation
Maturation of protein-coding transcripts in eukaryotes involves several processing steps, including 5′ capping, splicing, and 3′ end processing. The latter entails endonucleolytic cleavage of the nascent pre-mRNA and addition of a poly(A) tail to the resultant free 3′ end. The poly(A) tail then …
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Multi-domain Protein Unfolding Pathway Studies by Single Molecule Techniques
<p>Large multi-domain proteins, which are ubiquitous in the proteomes in eukaryotic and prokaryotic organisms, still lack intensive studies on their folding mechanisms due to their complicated interactions between and inside of their domains. My work is broadly aimed at characterize folding …
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The Role of Cyp33 in MLL Mediated Gene Repression
<p>Mixed Lineage Leukemia (MLL) is a multidomain protein whose gene is translocated in a subset of AML leukemias. Translocation of the MLL gene is present in approximately five percent of adult acute leukemias and ten percent of pediatric leukemias (Daser, A 2004, Look, A 1997, Huret, J 2001) …