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Showing 1 to 5 of 5 for “"Multicomponent crystals"”.
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Crystal Engineering of Pharmaceuticals: Modulating Physicochemical Properties of Active Ingredients by the Formation of Cocrystals
… along with solubility and drug release of cocrystals is found to be superior to that of nifedipine. Lastly, crystal engineering principles utilised in preparation of multicomponent crystals of antidiabetic model drugs, glyburide and chlorpropamide with various coformers. Interestingly, during …
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Phase equilibria from molecular simulation
… aimed to elucidate what drives the formation of multicomponent crystals, improve available models for exploring phase equilibria phenomena and explore solubility prediction from first principles as a potentially more powerful alternative to correlation based methods. These three fundamental areas …
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Impact of mixed solvent on co-crystal solubility, ternary diagrams and crystallisation scale-up. Crystallisations of Isonicotinamide ¿Benzoic Acid Co-crystals from Ethanol ¿Water Co-solvent System.
… in the preparation method. The formation of co-crystals has emerged as a new alternate to the salts, hydrates and solvate methods since the molecules that cannot be formed by the usual methods might crystallise in the form of co-crystals. Co-crystals are multicomponent crystals which can be …
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The design and synthesis of novel pro-drugs for the treatment of nephropathic cystinosis.
Cystinosis is a metabolic disorder characterised by the abnormal accumulation of the amino acid cystine in cells leading to a slow destruction of all major organs. If patients diagnosed with cystinosis are untreated, death due to kidney failure ensues in the second decade of life. A number of …
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Evaluation of Dose-Exposure-Response Relationships of Miltefosine and Discovery of Multicomponent Crystal Forms of Artesunate
… Furthermore, the study aimed to discover novel multicomponent crystal forms of ATS with enhanced physicochemical properties. The solubility of ATS and the dissolution performance of ATS and its crystal forms in buffer solutions were also evaluated. Method: The solid-state properties of …