Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Multicellular tumour spheroids"”.
-
Differential membrane-type matrix metalloproteinase expression in phenotypically defined breast cancer cell lines: Comparison of MT-MMP expression in environmentally-challenged 2D monolayer cultures and 3D multicellular tumour spheroids
… proliferation, apoptosis, regulation of tumour expansion, angiogenesis and invasion. Previous research has indicated high expression of MT1-MMP in breast cancers suggesting a potential role in tumour progression. Our results confirm that 3D multicellular tumour spheroids (MCTS) using …
-
Solid and hollow gold nanoparticles as radiosensitisers in combination with x-ray radiation and targeted radiopharmaceuticals
… apoptotic cell death was assessed. The growth of spheroids was examined by assessing changes in spheroid volume. Significant radiosensitisation was observed in UVW/NAT and SK-N-BE cells, when solid AuNPs and HGNs were combined with [¹³¹I]-MIBG which was associated with an increase in DNA DSB …
-
Mathematical modelling of tissue metabolism and growth
… cycle and metabolism. We consider two cases; multicellular tumour spheroids and orthopaedic tissue constructs. This thesis is divided into two parts. In the first part we will present a multispecies model of an avascular tumour that studies how a cell’s metabolism affects the cell cycle, …