Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Multicellular organism"”.
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The Inhibitory Effects of Acetic Acid on Enteric Bacteria
The surface of a multicellular organism, exposed to the external environment, either directly or indirectly, is inhabited by a specific microbial flora. This holds true regardless of the species or environment of the multicellular organism's The microbial flora of the multicellular organism, man, …
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An Analysis of Morphogenetic Movements on the Marginal Indentations of the Chick Embryo Yolk Sac
The normal production of a multicellular organism from a single-celled zygote depends upon the processes of growth, differentiation, and morphogenesis. The classification of an organism as multicellular necessitates the involvement of the growth process, since multicellularity implies the …
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The Ribosome and Its Role in Early Development.
The cells of any given multicellular organism arise from a single fertilized egg by mitotic divisions. This implies that every cell has the same chromosomal content and thus the same genetic information. Such an assumption was verified by Gurdon (1962) who transplanted nuclei from single somatic …
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The design, characterization, and application of CRISPR-based tool in human cells
… the diverse phenotypic traits observed within a multicellular organism possessing a single genotype. Now we understand that homeostasis arises when the rich interplay of epigenetic mechanisms functions correctly. With our ever growing set of CRISPR-based tools, we are on the precipice of targeted …
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Temporal control of vulval precursor cell fate patterning in Caenorhabditis elegans
Development of a multicellular organism requires precise coordination of temporal and spatial cues to ensure that developmental events occur at the correct time and place. C. elegans vulval development offers a convenient experimental system for investigating the temporal and spatial regulation of …
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Integrated functional anlaysis of quorum-sensing in the rice pathogenic bacterium Burkholderia glumae
… bacterial cells to collectively behave like a multicellular organism. It regulates the expression of toxoflavin, one of the major virulence factors of the rice pathogen, Burkholderia glumae. The QS system of B. glumae is mediated by the core genes, tofI and tofR. N-octanoyl-L-homoserine …
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Optogenetic control of developmental signaling pathways
How a complex multicellular organism forms from a single cell is a question that defies simplistic understanding. Yet, embryonic developmental programs use a surprisingly small set of signaling pathways to pattern the embryonic tissue into germ layers from which the various tissues and organs …
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Noise and multistability in gene regulatory networks
… In this way, every differentiated cell in a multicellular organism remembers its expression profile throughout its life. On the other hand, biochemical reactions that take place during gene expression involve small numbers of molecules, and are therefore dominated by large concentration …
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The Metabolic Transitions Regulated by the Estrogen-related Receptor (ERR) in Drosophila melanogaster
<p>In multicellular organism, bioenergetic metabolism is strictly regulated toward efficient generation of ATP. However, in certain situations, such as in limiting oxygen or in the rapidly proliferating system like growing juvenile or cancer cells, organisms apply the metabolic strategy that favors …
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PERPETUATION OF NON-GENETIC CHANGES AT A TRANSGENE LOCUS IN C. ELEGANS
Development of a multicellular organism from a single cell or from a few cells in every generation relies on the reproducible expression pattern of genes. At the beginning of every generation in every organism, at least a single progenitor cell is necessary to produce the organism. This cell is …
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The developmental role and regulation of the Anaphase-Promoting Complex/Cyclosome in Drosophila meiosis
… Complex/ Cyclosome (APC/C). During oogenesis of multicellular organisms, molecular control of meiosis has an added complexity because these divisions must be coordinated with the growth and development of the oocyte as well as its fertilization. The Drosophila gene cortex (cort), a putative …
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Specificity of SH2 domains and protein tyrosine phosphatases
A multicellular organism must be able to coordinate the actions of its cells in order to function effectively. As such, cells have developed mechanisms to sense and respond to changes in their environment and signals from other cells. One common mechanism by which signals are transmitted within …
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Characterizing the role of Nucleosome Remodeling Factor (NURF) in tumorigenesis and metastatic progression using mouse models of breast cancer.
… types sharing identical gene sequences in a multicellular organism gives a broad sense for the inherent role of epigenetic influence on cell differentiation. Importantly, the epigenetic mechanisms involved in establishing cell identity unsurprisingly contribute to diseased states, including …
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Gene expression profiling in different stages of development of Arabidopsis thaliana leaftrichomes at the single cell level
Each organ of a multicellular organism is unique at the level of its tissues and cells. Furthermore, responses to environmental stimuli or developmental signals occur differentially at the single cell or tissue level. This underlines the necessity of precise investigation of the “building block of …
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Spatiotemporal control of gene expression in Caenorhabditis elegans
… Caenorhabditis elegans is an important model organism for studying develop- mental processes. At the beginning of my PhD, I helped characterize the dynamics of gene expression and chromatin activity across development and aging. Follow- ing this, I aimed to identify and characterize the …
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Developmental Single-Cell RNA Sequencing in the Sea Urchin Species Lytechinus variegatus and Heliocidaris erythrogramma
… by which a single cell develops into a complex multicellular organism with specified cell types and well-defined cellular roles is not completely understood, and the evolution of that process is even more enigmatic. In sea urchin embryos, cell fate specification and differentiation of cell types …
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A study of mammalian microRNA-mediated repression of gene expression by ribosome profiling
All cells in a multicellular organism carry the same genes, yet these same genes direct the differentiation of many different cell types. This is facilitated by differential gene expression, the control of which can be exerted at the transcriptional, as well as post-transcriptional, level. …
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Molecular Basis of Vertebrate Embryonic Migration
… a single fertilized cell develops into a complex multicellular organism. Initially the embryo is no more than a ball of cells where the three primordial layers, the ectoderm, mesoderm and the endoderm are one on top of the other. The three germ layers will go on to form all the tissues and organs …
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Identification of a Novel Regulator of ER Stress-Induced Apoptosis
<p>The survival and development of a multicellular organism is reliant upon proper cell and organelle function, and the tight regulation of cell number. The endoplasmic reticulum (ER) is the cellular compartment where membrane and secretory pathway proteins are folded and modified for transport …
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Regulation and patterning of cell differentiation and pluripotency
The development of a multicellular organism from an embryo is one of the nature's most remarkable phenomena. Deciphering how this transformation occurs is a fundamental challenge in biology with profound biomedical implications. Insights into the molecular signals guiding developmental patterning …