Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Multicellular Systems"”.
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Tools for engineering multicellular systems through cell sorting and cell state detection
… that expands our ability to engineer and control multicellular systems by detecting and rewriting the cell state. We first develop a method that enables the creation of a synthetic cell state to control morphogenesis. Using inducible expression of recombinases, we show this approach can induce a …
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Emergence of collective behavior and phase transition in multicellular systems through long-range mechanical interaction
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01
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FREQUENCY AND AMPLITUDE CONTROL OF CORTICAL OSCILLATIONS BY LIPID METABOLISM
… importance to cell physiology in single and multicellular systems. Currently, majority of the studies focus primarily on cytoskeleton-dependent feedbacks. In contrast, information on signaling mechanisms upstream of the actin cytoskeleton remains unclear. In my study, I report …
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Computational Models of Ex Vivo HIV-1 Dynamics and Fitness Across Scales
When modeling multicellular systems, we are often interested in mapping collective macroscopic behavior to cell level characteristics, and vice versa. One of the difficulties in bridging cell level and macroscopic scales is how to interpret the meaning of model parameters when moving from one scale …
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Collective Dynamics of Interacting Cell Types
… new ways to study and conceptualize biological systems. This shift is particularly pronounced in the context of complex multicellular organisms, where single-cell technologies allow us to dissect tissue heterogeneity at the level of individual cells. For the theoretical sciences, this wealth of …
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Thermodynamic and topological characterization of living systems
… dynamics, and response of complex biophysical systems at single-cell and subcellular resolution, from bacterial communities and tissues to intra-cellular signaling and expression dynamics of genes. Despite such progress in data collection, major theoretical challenges remain to find structure …
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Impact of Vimentin Intermediate Filaments on 3D Multicellular Collective Behavior
… in a Matrigel-Alginate gel, which then grow into multicellular systems. The MCF-7 cells utilized are vimentin null, chemically inducible to form vimentin networks that interact with the other components of the cytoskeleton. These MCF-7 allow for controlled expression of mature vimentin …
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Gene Expression Control for Synthetic Patterning of Bacterial Populations and Plants
The development of shape in multicellular organisms has intrigued human minds for millenia. Empowered by modern genetic techniques, molecular biologists are now striving to not only dissect developmental processes, but to exploit their modularity for the design of custom living systems used in …
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Propagation of engineered cellular properties to colony scales in bacterial populations
… avoiding the complexity present in natural multicellular systems. A range of microscopy techniques and image processing tools were established to measure cellular properties and cellular arrangements, as well as the dynamics of colony growth. The experimental work was closely integrated with …
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Technologies to decode the multicellular networks within the human body
… of cells to physically assemble into coordinated multicellular systems. In other words, how millions of individual cells are able to physically interact with each other in an organized way, as well as how pathogens such as viruses can exploit these interaction points in order to infect the body. …