Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Multi-state models"”.
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Continuous Time Multi-state Models for Survival Analysis
… survival analysis techniques for continuous time multi-state models. It explores homogeneous Markov models, homogeneous semi-Markov models, non-homogeneous Markov models, and general models. It also discusses the likelihoods, hazards, and probabilities for each model. This paper examines …
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Multi-state models for the analysis of Wheeze in a birth cohort of Western Cape children
… middle-income contexts. This study aimed to use multi-state models to estimate the rate of transition among various states of wheeze in children from birth to the age of three years. This study also aimed to investigate the association between possible risk factors for childhood wheezing and the …
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On change in length of stay associated with an intermediate event: estimation within multi-state models and large sample properties
… equal to the time spent in the <br>intermediate state. We suggest and study functionals quantifying <br>change in length of stay. Our approach applies quite generally to <br>functionals summarizing the impact of an intermediate on a terminal <br>event.
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Multi-state modelling to estimate infectious disease burden
… lives. In this thesis I aim to develop and apply multi-state models to estimate infectious disease burden from observational data. Multi-state models are a flexible approach to estimating risks and lengths of stay, and capable of accounting for data biases and censoring. I demonstrate the …
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Modelling Hepatitis C virus infection and treatment impact through serological surveillance data
… populations. I first apply catalytic and multi-state models to UAM data to estimate injecting dura- tion–specific and time-varying HCV incidence. By incorporating serological and virological markers, these models are extended to account for reinfection and treatment-induced clearance. …
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Estimating Non-homogeneous Intensity Matrices in Continuous Time Multi-state Markov Models
Multi-State-Markov (MSM) models can be used to characterize the behaviour of categorical outcomes measured repeatedly over time. Kalbfleisch and Lawless (1985) and Gentleman et al. (1994) examine the MSM model under the assumption of time-homogeneous transition intensities. In the context of …
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Longevity Risk: Retirement Product Innovation and Risk Management Strategies
… disability risks in a pooled annuity fund using multi-state models of functional disability and health status. We make two contributions to the literature. First, we propose a theoretical framework for pooling mortality risk across multiple health states. Second, as a practical contribution, we …
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Using biomarker data to monitor the HIV epidemic
… propose a novel approach to make probabilistic statements on the recency of HIV infection by combining the knowledge on the growth of such biomarkers with observations from a newly diagnosed individual. Univariate and bivariate non-linear mixed-effects models are implemented in a fully Bayesian …
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Temporal interactions of microbiota in longitudinal nasopharyngeal samples and association with lower respiratory tract infection
… (during the first year of life). The presence of multiple NP bacteria results in competitive and synergistic associations, however temporal organism interactions have rarely been explored due to limited availability of longitudinal data sets, and the complex statistical methods needed. This study …
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Monitoring for Chronic Wasting Disease in Mule Deer and White-Tailed Deer at Wind Cave National Park: Investigating an Emerging Epizootic
… home ranges with limited social contact. Thus, models of CWD transmission in deer should include home-range overlap because of the possibility of environmental contamination. For objective 3, estimates of mortality rates are essential for understanding population dynamics of ungulates. …