Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Multi-protein complex"”.
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Computational Investigations of Cellular Functions: Three Cases on Membrane Morphogenesis, Organization and Assembly of a Multi-Protein Complex, and the Molecular Origin of Muscle Elasticity
Titin is a mechanical protein that protects muscle from overstretching by producing a restoring force when a muscle fiber is extended beyond its normal length. Force spectroscopy studies have shown that titin exhibits several regimes of elasticity. Disordered segments bring about a soft, entropic …
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Computational investigations of cellular functions: Three cases on membrane morphogenesis, organization and assembly of a multi-protein complex, and the molecular origin of muscle elasticity
… of the biological membrane, assembly of a multi-protein complex, and the molecular origin of elasticity in muscle protein. In the photosynthetic purple bacterium Rhodobacter (Rba.) sphaeroides, light is absorbed by membrane-bound light-harvesting proteins LH1 and LH2. LH1 directly surrounds …
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Identification and Characterization of Pat-6/actopaxin in Caenorhabditis Elegans Body Wall Muscle
In addition, I identified PAT-4/ILK and a novel protein, K10B2.5, as putative binding partners of PAT-6/actopaxin. PAT-6/actopaxin and PAT-4/ILK colocalize in vivo, forming a multi-protein complex with UNC-112. The accumulation of PAT-6/actopaxin in body wall muscle cells requires PAT-4/ILK kinase …
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The proteasome and its ancillary proteins
The proteasome is an essential multi-protein complex found within all eukaryotes. It degrades unwanted proteins and is involved in regulating many cellular functions, including cell homeostasis and apoptosis. Previous research in the field mainly focused on the mechanisms by which substrate …
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Role of the COP9 Signalosome In Defense Responses In tomato
… Signalosome (CSN) is an evolutionarily conserved multi-protein complex that regulates proteasome-mediated proteolysis. While the CSN has been shown to function in various growth and developmental processes, the involvement of the CSN in the regulation of defense responses is largely unknown. It …
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Mechanisms that prevent DNA re-replication in the yeast Saccharomyces cerevisiae
… regulate the components of the pre-Replicative Complex (pre-RC) to prevent re-replication. The pre-RC is a multi-protein complex that assembles at origins during G1, before DNA replication begins. After an origin initiates pre-RC components must be prevented from reassembling at origins until …
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Investigation of coiled-coil interactions between proteins of the spindle pole body
The spindle pole body (SPB) is a large multi-protein complex that organizes microtubules in yeast. Through its function of nucleating and anchoring microtubules, the SPB is essential for cell viability. High-resolution structures of the SPB have not been achieved using x-ray crystallography, due to …
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Structure-function analysis of ZapC, an FtsZ-ring stabilizer, in Escherichia coli cytokinesis
… Division also involves the formation of a multi-protein complex at midcell known as the divisome. Several divisome proteins promote the assembly/disassembly processes of FtsZ, thereby exercising spatiotemporal control over division. Among FtsZ regulatory proteins are the FtsZ ringassociated …
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Extracellular matrix protein receptors in Drosophila melanogaster
… matrix (ECM) is defined as the many different proteins and secreted substances between cells. The ECM plays a major role in the signaling pathways that stimulate cells to perform many varied functions, ranging from control of gene expression at the cellular level to differentiation and …
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Kinetochore Structural Plasticity and its Regulation in <i>Saccharomyces cerevisiae</i>
The kinetochore is a multi-protein complex that connects the chromosome with microtubule and pulls the chromosome during chromosome segregation. In yeast, a single kinetochore assembles on a Cse4 nucleosome and attaches to a single microtubule, making it an ideal system for studying the …
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Architecture of eukaryotic mRNA 3' end processing machinery and insights into the mechanism of polyadenylation
… (polyA) tail at their 3′ end that is added by a multi-protein complex known as cleavage and polyadenylation factor (CPF). CPF, along with accessory cleavage factors (CF) IA and IB, cleaves the pre-mRNA within the 3' untranslated region (UTR) and adds a poly(A) tail. Previous work has shown that …
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Mechanisms of mRNA substrate-selection by the Ccr4-Not deadenylase complex
… is predominantly catalysed by a conserved multi-protein complex called Ccr4-Not. While the poly(A) tail is a feature of almost all mRNAs, cells control the rate at which each undergoes decay by the precise targeting of Ccr4-Not in both a gene-dependent and a context-dependent fashion. …
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Single molecule fret study on the mechanism of RecA mediated strand exchange
… resolution to observe the encounter complex between the RecA filament and dsDNA, we present evidence in support of the “sliding model” wherein a RecA filament diffuses on a dsDNA track. Our results suggest that the sliding of the dsDNA relative to the RecA filament can explain the …
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Battling Bacteria: Characterizing the NOD-Like Receptor (NLR) Immune Response to <i>Brucella abortus</i> and <i>Borrelia burgdorferi</i> in Host-pathogen Interactions
… of pro-inflammatory receptors that form a multi-protein complex termed the inflammasome, as well as regulatory NLRs that modulate inflammation. Here, we investigated the roles of inflammasomes and negative regulatory NLRX1 in response to bacterial diseases. First, we studied brucellosis, a …
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Modulation of Alphaviruses by Small RNAs
… viral RNAs when loaded and retained in a multi-protein complex called the RNA-induced silencing complex. Here, we show that mosquito vectors mount a redundant double defense against virus infection mediated by two different small RNA pathways. Specifically, we demonstrate that in addition …
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Testing the T-loop Model of Telomeric End Protection
… through the action of shelterin. Shelterin is a multi-protein complex where each subunit is dedicated to a specific role in repressing a form of DNA damage signaling, repair, or recruiting telomerase to extend the telomere end. One of the critical anchor points of shelterin is a protein known as …
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Endosomal membrane dynamics underlying cell spreading: A role for the small GTPase Arf6
… is an orchestrated and highly coordinated multi-step process that is central to the development and maintenance of multicellular organisms. Dysregulated migration however, is associated with pathological states such as tumor formation and metastasis; thus a clear understanding of the …
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Investigation of the role of CUZD1-STAT5 signaling in mammary gland development and breast cancer
… (CUB and zona pellucida-like domain containing protein- 1) as a novel mediator of PRL signaling in steroid hormone-primed mouse mammary gland and undertook an examination of its role in growth and differentiation of this tissue during pregnancy. CUZD1 expression is markedly induced in …
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Molecular modeling and simulation of bacterial chemosensory arrays
… which involves the clustering of thousands of proteins into a highly cooperative signaling network. The present dissertation will present my work using techniques in computational modeling and simulation to investigate the molecular structure and function of the bacterial chemosensory array. A …
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The Role of IGF-1 and Notch Signaling in Thoracic Malignancies.
… T antigen (Tag), p53, pRb and p300 function in a multi-protein complex to promote transcription of the IGF1 gene. Depletion of p53 in these cells causes growth arrest because of lack of IGF-1 synthesis. These results provide a novel mechanistic and biological interpretation of the p53/Tag …
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