Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Multi-modal Imaging"”.
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Multi-modal imaging of herpesvirus infection
… Furthermore, the precise roles of multiple viral gene products that are important for HSV- 1 assembly remain to be fully characterised. I used cryo-soft-X-ray tomography to image the ultrastructure of cryopreserved infected cells in 3D. In order to analyse these tomograms I …
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In vivo multi-modal imaging approaches for cancer, stem and immune cells
Introduction: Molecular imaging allows for non-invasive longitudinal visualization of cellular functions in vivo. This area of research has provided better understanding of fundamental molecular and biochemical processes, enabled optimization of pre-clinical and clinical assessments for new …
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Multi-modal imaging of cementitious carbonation front – insights on performance of low-clinker blends
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Development of Multi-Modality Imaging Cart for Barrett’s Esophagus
… building a risk progression model by using a multi-modal imaging system combining autofluorescence spectroscopy, optical coherence tomography, and diffuse reflectance spectroscopy to perform label-free optical biopsies on ex-vivo tissue. These images will be co-registered and validated with …
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Anisotropic variational models and PDEs for inverse imaging problems
… equations (PDEs) for solving inverse imaging problems that arise in a variety of real-world applications. Firstly, we introduce a new anisotropic higher-order total directional variation regulariser. We describe both the theoretical and the numerical details for its use within a …
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Ultrasonic imaging methods for quantitative musculoskeletal tissue assessment and improved prosthetic interface design
… are limited since it relies on expensive imaging technologies and robotic indentation devices. Medical ultrasound imaging, a cost-effective modality that can be used at the bedside, is a promising and clinically-viable solution. In order for ultrasound to become a viable scanning method …
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Imaging Correlates of Heterogeneity in the Syndromes Associated with Frontotemporal Lobar Degeneration
… the same clinical presentation can be caused by multiple pathological entities. Heterogeneity makes predicting underlying pathology and longitudinal outcomes challenging in clinical practice and in research settings. I propose that a multi-modal imaging approach, including structural and …
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Visualisation and manipulation of 3D patient-specific bone geometry using augmented reality
… experienced by clinicians due to integrating multi-modal imaging data from several sources while performing the intervention on the patient. Three AR HMD systems have been developed to explore the capabilities of the Microsoft HoloLens as an AR HMD to be used in developing an AR HMD medical …
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Imaging through optical multimode fiber: towards ultra-thin endoscopy
Optical imaging in biomedicine provides pathophysiological information with high resolution, high speed, and minimal invasiveness. Endoscopy in particular has revolutionized healthcare diagnosis and treatment as well as biological research by offering visual access to otherwise unreachable remote …
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Neuronal and Vascular Degeneration of the aging retina in the 3xTg-AD mouse
… dysfunction, and neuroinflammation. Diagnostic modalities to detect the early phases of these CNS pathologies in preclinical AD are inadequate. Vision abnormalities are common in AD, and Aβ and tau have been detected in the retina parallel to the brain. Noninvasive detection of early AD …
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Hierarchical Bayesian Models for Multimodal Neuroimaging Data
Within the past few decades, advances in imaging acquisition have given rise to a large number of in vivo techniques for brain mapping. This wide range of structural and functional imaging modalities provides a major source of information-rich data which may be used to non-invasively understand the …
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AI Assisted Cellular and 3D Spheroid Analyses for Combined Therapies Against Glioblastoma
… For RT+Len in 3D spheroids, brightfield imaging achieved 95% separation of combination therapy from lenalidomide-only spheroids at 24 hours despite subtle visual differences. At 48 hours, calcein viability imaging revealed exceptional clustering quality (silhouette 0.65, cophenetic …
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Transparent neural interfaces for simultaneous electrophysiology and advanced brain imaging
Imaging and electrophysiology are the most fundamental tools in neuroscience research. On the one hand, optical imaging can target specific molecules with high spatial resolution *in vitro* and *in vivo*. Spectroscopic techniques like magnetic resonance imaging (MRI) can access deep regions of the …
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High-sensitivity Full-field Quantitative Phase Imaging Based on Wavelength Shifting Interferometry
Quantitative phase imaging (QPI) is a category of imaging techniques that can retrieve the phase information of the sample quantitatively. QPI features label-free contrast and non-contact detection. It has thus gained rapidly growing attention in biomedical imaging. Capable of resolving biological …
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Multi-modal characterization of cements and irradiated granites
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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Anisotropic surface functionalization and applications of upconversion nanoparticles
… these particles to perform biomolecular assays, multi-scale and multi-modal imaging, as well as targeted delivery of drugs for nanoscale therapies. To make these inorganic nanomaterials practically useful, their surfaces require functionalization with active chemical groups that target important …
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Drug Loaded Multifunctional Microparticles for Anti-VEGF Therapy of Exudative Age-related Macular Degeneration
… perform sustained release of anti-VEGF drug by multifunctional drug-loaded microparticles (MPs).</p><p>A modified double emulsion technique has firstly been used to fabricate biodegradable poly-lactic-co-glycolic acid (PLGA) MPs. The MPs could provide fluorescence, ultrasound, and OCT contrast …
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Tau pathology, microglia activation, and network dysfunction in Alzheimer’s disease
… by combining: 1) positron emission tomography imaging using the [18F-AV]-1451 tracer (measuring in vivo tau pathology) or [11C]PK11195 ligand (indexing in vivo neuroinflammation), with 2) connectivity measures of resting-state functional magnetic resonance imaging. I found increased …