Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Multi-drug resistant TB"”.
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Three-Dimensional (3D) pharmacophore-based identification of possible ATP-synthase inhibitors for mycobacterium tuberculosis (Mtb)
Tuberculosis (TB) is defined as a chronic infectious disease caused by the air-borne transmission of Mycobacterium tuberculosis (Mtb). Due to high prevalence of Mtb in South Africa, it is classified as a high burden country by the World Health Organization (WHO). Multi-drug resistant TB (MDR-TB) …
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Synthesis, characterisation, structure-activity and structure-property relationship studies of quinazolinones as antimycobacterial agents
Mycobacterium tuberculosis (Mtb) is the pathogen responsible for Tuberculosis (TB), one of the most prolific killers among communicable diseases, second only to HIV/AIDS. The World Health Organisation (WHO) estimated 10.4 million people contracted TB in 2015, with 1.4 million fatalities recorded in …
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Design, Synthesis, and Evaluation of Novel Antimycobacterial Agents With Enhanced Pharmacokinetic Profiles
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb), is one of the leading causes of death worldwide. The present short-course therapy is six months long for drug-susceptible M. tb strains, and up to two years for multi-drug-resistant TB (MDR-TB) and extensively drug-resistant TB …
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Prevalence of drug-resistant tuberculosis and associated risk factors among patients in the Northern Region of South Africa
Background: Drug-resistant TB is a major global health threat, driving the ongoing TB epidemic and increasing morbidity and mortality worldwide. Currently, national tuberculosis (TB) control programmes are challenged by the emergence of drug resistance to more anti-TB drugs resulting in multi-drug …
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Development and validation of selective and sensitive LC-MS/MS Methods for determination of para-aminosalicyclic acid and cycloserine/terizidone applicable to clinical studies for the treatment of tuberculosis
… 3000 mass spectrometer at unit resolution in the multiple reaction monitoring (MRM) mode was used to monitor the transition of the protonated precursor ions m/z 154.1 and m/z 181.2 to the product ions m/z 80.2 and m/z 95.2 for PAS and the ISTD, respectively. Electro Spray Ionisation (ESI) was used …