Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 66 for “"Multi-drug resistance"”.
-
The Role of Multi-Drug Resistance Associated Protein 4 and P-glycoprotein in Resistance of Neuroblastoma to Topotecan and Irinotecan
… less than 30% despite the use of surgery, multi-agent chemotherapy, radiation, and autologous bone marrow transplant. Novel therapeutic modalities are under development. The camptothecin analogs topotecan and irinotecan have been identified as successful cytotoxic agents. For topotecan, …
-
Prevalence of multi-drug resistance tuberculosis MDR-TB and associated risk factors among patients in Vhembe Region of Limpopo. South Africa
BACKGROUND: The increasing prevalence of drug-resistant tuberculosis (DR-TB) poses a critical and significant obstacle in the management of tuberculosis (TB) worldwide. This driven by the emergence of multidrug-resistant tuberculosis (MDR-TB) strains and co-infection of TB with human …
-
Factors that influence the utilisation of ototoxicity monitoring services for patients on treatment for drug-resistant tuberculosis
Multi-drug resistance is increasingly becoming a challenge to tuberculosis control programmes globally. Treatment of multi-drug resistance tuberculosis (MDR-TB) includes aminoglycoside antibiotics which are known to cause hearing loss. Ototoxicity monitoring services are often provided to patients …
-
In vitro efficacy tests against Mycobacterium species of South African traditional medicinal plants
… people each year, worldwide. The emergence of multi-drug resistance and HIV/AIDS are the major causes of this problem. New therapeutic agents with a different mode of action, and thereby of resistance to Mycobacterium tuberculosis, the causative agent, are needed urgently. Amongst the methods …
-
Targeting Airway Microbiome Dysbiosis for Preventing Pediatric Subglottic Stenosis
… physicians advise against them as the risk of multi-drug resistance and growth retardation outweigh the potential benefits. Therefore, we use antimicrobial peptides (AMPs), small, naturally occurring biomolecules that physically disrupt microbial membranes thus avoiding the risk of multi-drug …
-
Collateral sensitivity and the evolution of drug resistance in Escherichia coli
… could reduce rates of evolution of antibiotic resistance in pathogens. To explore this idea, I tested the key assumption that collateral sensitivity should reduce the frequency of mutation to resistance. Ceftazidime resistant strains showed susceptibility to chloramphenicol. It was therefore …
-
Antimycobacterial 2-aminoquinazolinones and benzoxazole-based oximes: synthesis, biological evaluation, physicochemical profiling and supramolecular derivatization
… such as lengthy and complex treatment regimens, drug-drug interactions, drug toxicities, as well as emergence of widespread multi-drug resistance. Therefore, there is an urgent and compelling need to develop new, more effective, safer drugs with novel mechanisms of action, and which are capable …
-
Populations of Escherichia coli in clinical samples of Urinary Tract Infections and bacteraemia
… in the literature with increased prevalence of multidrug resistance driven by extended spectrum β lactamases (ESBLs). ESBL carriage and multidrug resistance of bacteraemia E. coli is on the increase yet little information is available about their population structure. With the aim to define the …
-
The emergence of <i>Escherichia coli</i> with CTX-M extended-spectrum beta-lactamases in the United Kingdom
In the past decade, multi-resistant <i>Escherichia coli</i> with CTX-M enzymes have rapidly become the leading producers of extended-spectrum β-Iactamases (ESBLs) worldwide. <i>E. coli</i> with CTX-M-15 β-Iactamases are the most common, and are now endemic in many UK hospitals and in the community. …
-
Assessment of motility and hemolytic activity in clinical isolates of Acinetobacter baumannii from University of Kentucky hospital, Lexington, KY
… notoriety worldwide due to outbreaks linked to multi-drug resistant strains. Research is currently focused on identifying virulence factors, which may contribute to increased ability to cause human disease, such as hemolytic activity and surface motility. The aim of this study was to determine …
-
Subcellular Localization and Activity of the Multidrug Resistance Protein 1
<p>Multi-drug resistance or MDR is a major impediment to the successful administration of chemotherapy. Broadly defined, the term MDR applies to any mechanism the cell uses to counter the effects of chemotherapeutic agents, protecting the cell at once against the toxicity of many, structurally …
-
Anti-cancer and anti-malarial 4-aminoquinoline derivatives : synthesis and solid-state investigations
… molecules in an attempt to render these dual drugs water-soluble. Of all the current clinically established antimalarials, the 4-aminoquinolines haveproven to be the most significant and efficacious for the treatment and prophylaxis of malaria. However, their efficacy has decreased by the …
-
QUB-2825: A novel bioactive peptide from the skin secretion of Phyllomedusa hypochondrialis
… as alternative candidates for the treatment of multi-drug resistance microbes. The dermaseptins consist of a superfamily within amphibian AMPs, which also possess anticancer activities with weak haemolytic effect. <br/><br/>My research aims at searching for a novel bioactive peptide from the …
-
Comparison of Redox-Active and Conjugative Enzymes With and Without Efflux Transporters and Their Comparative Effectiveness in Protection Against Cellular Toxicity of 4-Hydroxy-2-Nonenal (HNE), an Aldehyde Lipid Peroxidation Production
… Thus, efflux transporters including multi-drug resistance proteins (MRP1/MRP2) may be required for removal of HNE-SG. The combined role of GSTs with MRP1/2 was studied in stably transfected MCF7 and a HepG2 cell line model. Co-expression of GSTM1 + MRP1 leads to increased HNE-protein …
-
The role of microvesicles in cancer and viral infection
… This thesis also identified a new mechanism for multi-drug resistance involving the efflux of anticancer drugs from cancer cells mediated by release of microvesicles, removing the drug from treated cancer cells. Immunoblotting and flow cytometery data showed that transcriptional silencing of …
-
A study on the detection of extended spectrum beta lactamase producers and class I intergrons in e. coli isolates from urinary tract infected patients at UTH.
… Beta lactamases are the primary cause of resistance to beta lactam antibiotics. These enzymes confer multi drug resistance (MDR) thus limiting and complicating treatment options. The beta lactamase resistant genes are usually encoded on plasmids and often confer resistance to other classes …
-
A study on the detection of extended spectrum beta lactamase producers and class I intergrons in e. coli isolates from urinary tract infected patients at UTH.
… Beta lactamases are the primary cause of resistance to beta lactam antibiotics. These enzymes confer multi drug resistance (MDR) thus limiting and complicating treatment options. The beta lactamase resistant genes are usually encoded on plasmids and often confer resistance to other classes …
-
Genotyping antibiotic resistance properties of escherichia coli and campylobacter jejuni associated with diarrhoea in young children in the Vhembe District
… children in Sub-Saharan Africa. While antibiotic resistance among enteric pathogens such as Escherichia coli (E. coli) and Campylobacter spp. is increasing, surveillance of antimicrobial resistance genes (ARG) is limited in Africa. The need for such studies in Africa was demonstrated by our …
-
Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
… agent of melioidosis. Because of intrinsic multi-drug resistance, lack of effective treatment and high case-fatality rates, this organism is classified as a Tier 1 Select Agent and considered a priority for vaccine development. Previous studies have shown that glycoconjugate vaccines can …
-
Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
… agent of melioidosis. Because of intrinsic multi-drug resistance, lack of effective treatment and high case-fatality rates, this organism is classified as a Tier 1 Select Agent and considered a priority for vaccine development. Previous studies have shown that glycoconjugate vaccines can …
Page 1 of 4