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Showing 1 to 11 of 11 for “"Mukaiyama Aldol Reaction"”.
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I. Chemoselective Dehydrative Glycosylation With Application Toward Oligosaccharide Synthesis. II. Sulfide-Mediated Direct Glycosylation of C(1)-Hydroxyl Glycosyl Donors. III. Studies Toward the Total Synthesis of Auriside A
… is accomplished in 17 linear steps using the Mukaiyama aldol reaction, the intramolecular Mitsunobu macrolactonization, and the Julia olefination for the installation of the C(5)-stereogenic center, the 14-membered macrolactone, and the conjugated bromodiene moiety, respectively.
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The progress towards the total synthesis of (ent)-MPC1001
… However, the key ring-closing metathesis reaction provided irreproducible results. Therefore, a macrolactonization was utilized to synthesize an advanced lactone derivative. Current research is focused on the elaboration of the lactone to the oxepin ring. Efforts were also focused on the …
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Efforts towards the Total Synthesis of Azaspiracid-3
… ABCD domain involved an efficient NHK coupling reaction between C1-C12 segment and C13-C22 segment. The trioxadispiroketal skeleton was constructed under the influence of acid catalysis. The EFGHI domain highlighted a chelate controlled Mukaiyama aldol reaction to produce C22-C40 linear …
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Studies directed towards the synthesis of (-)-Ebelactone-A
… enriched 20 devised by Williams, employing a Mukaiyama aldol reaction directed by Oppolzer's sultam to establish the anti-anti stereotriad of the fragment. We modelled the coupling of this to 115 using isobutyraldehyde in place of 20 and vinyl iodide 133 in place of 115, and verified that the …
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Applications of novel boron-nitrogen containing heterocycles : design and synthesis o planar-chiral Lewis acids for stereoselective organic synthesis
… reagents to imines and Lewis acid mediated Mukaiyama aldol reaction of aldehydes with silyl ketene acetals.
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The Kinetic Resolution of Secondary Alcohols Through A Tandem Enantioselective Silylation and the Synthesis of Bis(Oxazolidinyl)Pyridine Metal-Organic Complexes
… mild conditions in which to carry out the Mukaiyama aldol reaction. The design of a bi-functional organic chiral catalyst, which comprises of a Lewis base acetate anion paired with a chiral quaternary ammonium cinchona alkaloid, is discussed. We found that when the addition of a silyl …
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Studies Towards the Total Synthesis of the Chivosazoles
… three key fragments A, B and C, their coupling reactions and subsequent modifications for assembling the backbone of chivosazole F. Paterson boron aldol methodology and Evans-Tishchenko reduction were utilised to construct the 1,4-syn and 1,3-anti stereochemical relationships within both …
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Rhodium-Catalyzed Asymmetric Ring Opening of Oxabicyclic Alkenes and Palladium-Catalyzed Carbon-Halogen Bond Forming Reactions
Atom-economical addition reactions to unsaturated carbonâ carbon bonds represent a powerful class of transformations in organic chemistry, since a great deal of molecular complexity can be generated from simple starting materials. Highly regio- and stereoselective processes have been made possible …
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Lanthanide-Based Precatalysts For Carbon-Carbon Bond-Forming Reactions In Aqueous Media
… majority of biologically active compounds. The Mukaiyama aldol reaction is a Lewis-acid-catalyzed carbon-carbon bond-forming reaction that has the ability to produce optically active β-hydroxy carbonyls which can be found in many pharmaceuticals and natural products. Because of precatalyst …
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New adaptations of analytical tools for the study of dynamic interactions of lanthanide-based catalysis in aqueous media
… acid catalyzed carbon-carbon bond-forming reactions are of great interest in organic synthesis. However, many conventional Lewis acids, and almost all enantioselective Lewis acid catalysts, must be used under strictly anhydrous conditions to avoid hydrolysis and the difficulties associated …
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Quantenchemische Berechnungen zur enantioselektiv katalysierten Aldolreaktion
Die Mukaiyama-Aldolreaktion ist die Umsetzung eines Silylenolethers mit einer Carbonylverbindung in Gegenwart einer Lewis-Säure. Diese Reaktion ist eine wichtige Methode zur Knüpfung einer Kohlenstoff-Kohlenstoff-Bindung in der Organischen Chemie. In der vorliegenden Arbeit wird mittels …