Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Mucus Hypersecretion"”.
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Pathogenic roles of Pseudomonas aeruginosa-derived volatile organic compounds in airway mucus hypersecretion: Molecular mechanisms and immune modulation
This Dissertation was approved for publication on 2024-12-04 at 14:52.
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RESPIRABLE SIRNA TARGETING AT THE NF-KB PATHWAY PROTECTS AGAINST INFLAMMATORY LUNG DISEASES
… and mouse lung. RPS3 siRNA abated HDM-induced mucus hypersecretion, cytokine production, and serum IgE elevation. RPS3 and Rip2 siRNA ameliorated neutrophil infiltration and suppressed CS-induced inflammatory and oxidative damage marker levels. Here we reported that RPS3 and Rip2 siRNA …
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Deciphering the mechanism of foxa2 inactivation by respiratory pathogens in chronically diseased lungs
… box (FOX) family. FOXA2 regulates airway mucus homeostasis and acts as a transcription repressor of airway mucin5ac (MUC5AC) and mucin5b (MUC5B) genes. In diseased human and other mammalian airways, FOXA2 is inactivated in both club cells and ciliated cells, resulting in the …
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A microfluidic mucosal airway model to study airway mucosal function and pathogenesis
Airway mucus hypersecretion or impaired clearance is one of the key pathophysiological features of airborne infection, allergy and severe respiratory diseases. As foreign particles enter the lungs, the airway becomes inflamed and excessive amount of mucus is generated in response. However, little …
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Natural History of Biliary Sludge in Dogs
… associated with gallbladder (GB) dysmotility and mucus hypersecretion suggesting that these factors could lead to GB mucoceles. If biliary sludge does progress to GB mucoceles, treatments to reduce the production and progression of sludge are warranted. Objectives: The aim of this study was to …
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Studies on the effect of cysteinyl leukotrienes on human t cell differentiation and function
… such as eosinophilia, IgE production and mucus hypersecretion. Cysteinyl leukotrienes (CysLTs) are known potent lipid mediators involved in mucus production, bronchoconstriction and leukocyte migration, and act via the receptors CysLTiR and CysLT2R. Recently, CysLTs have been implicated in …
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Determining the Effects and Signaling Properties of β-Blockers in House Dust Mite-Driven Murine Models of Asthma
… features of asthma include airway inflammation, mucus hypersecretion, airway hyper-responsiveness and remodeling causing clinical symptoms such as recurrent coughing, wheezing, chest tightness, and shortness of breath. As often patients require life-long management of these symptoms, health care …
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The Role of Hydrocortisone on the Development and Maintenance of Ion Transport Pathways Essential to Mucociliary Clearance in Differentiated Normal Human Bronchial Epithelial Cells
… polymeric mucins that absorb water to form mucus. Ciliated cells propel the mucus gel towards the pharynx and out of the lungs by the directional, synchronized beating of cilia on the cell surface, effectively removing entrapped particles and pathogens from the lungs by a process known as …
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The role of elastase as an inflammatory stimulus in chronic obstructive pulmonary disease
… Elastase is also known to contribute to the mucus hypersecretion associated with chronic bronchitis. The proteolytic actions of elastase are well characterised but there is gathering evidence to suggest that it may also be able to act as an inflammatory stimulus, thereby increasing its role …