Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Mucosal immune system"”.
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ON THE NOSE: MUCOSAL IMMUNE RESPONSES DURING EQUINE HERPESVIRUS TYPE 1 INFECTION
The mucosal immune system is the first line of defense for a broad range of pathogens that greatly impact humans and veterinary species. The respiratory tract is the entry site of many high morbidity and mortality animal viruses, including equine herpesvirus type 1 (EHV-1). EHV-1 is endemic in …
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Characterization of Regulatory Mechanisms in Mucosal Immunity by Systems Immunology
The mucosal immunity of the gastrointestinal (GI) tract is constituted by a complex, highly specialized and dynamic system of immune components that aim to protect the gut from external threats. The sustained exposure of the mucosal immune system of the GI tract to an enormous number of lumen …
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Systems Immunology Approaches for Precision Medicine
The mucosal immune system encompasses a wide array of interactions that work in concert to protect an individual from harmful agents while retaining tolerance to molecules, microbes, and self-antigens that present no danger. The upheaval in the regulation-response balance is a critical aspect in …
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Immunomodulatory effects of dietary fibre supplementation: effects on cytokine and antibody production and lymphocyte population profiles
… have a bi-directional relationship with the host immune system. A variety of fermentable carbohydrate polymers largely pass through the small intestine, providing fermentable substrates for gut microflora. Dietary fibre supplementation may provide a strategy for manipulating the intestinal …
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Development of a mucosal vaccine delivery system
Vaccine delivery systems that target the mucosal immune system carry important advantages in terms of accessibility and acceptability. Lipid based nanoparticles with and without the incorporation of bile salts were formulated by novel preparation methods in order to provide suitable immunogen …
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Transdisciplinary Strategies for the Characterization of Mucosal Immune Responses to Enteric Pathogens
The gastrointestinal mucosal immune system has the daunting task of maintaining immune homeostasis by eliminating potentially harmful microorganisms and limiting tissue injury while inducing tolerogenic responses to luminal antigens including innocuous food, commensal bacteria and self-antigens. …
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The effect of iron supplementation and tumour location on the mucosal microbiological and immunological environment in colorectal cancer patients with iron deficiency anaemia
… the potential to alter the gut microbiota and mucosal immune system, potentially leading to inferior oncological outcomes. Previous animal studies have supported this association; however, here is provided the first human clinical studies to assess the microbiological and immunological outcomes …
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Modeling Host Immune Responses in Infectious Diseases
… people with suppressed and compromised immune systems are at higher risk of suffering from infectious diseases. In spite of significant advancements in infectious diseases research, the control or treatment process faces challenges. The mucosal immune system plays a crucial role in …
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Exploring the gut microbiome: metaproteome analysis of HIV-exposed uninfected infants
… to be more vulnerable to disease and have weaker immune responses. The gut microbiome plays a pivotal role in human health by aiding in metabolism, nutrient availability and immune development and function. The mucosal immune system and microbiome work in synergy to maintain host immunity and …
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IDENTIFICATION OF ADHERENT-INVASIVE ESCHERICHIA COLI (AIEC) VIRULENCE DETERMINANTS LEADING TO ACTIVATION OF PATHOGENIC TH17 CELLS IN CROHN¿S DISEASE.
… and persistent activation of the gut mucosal immune system in genetically predisposed individuals. So far, the accepted dogma is that CD arises from the overly activation of tissue-resident T-cells in response to a dysbiotic composition of the gut microbiota. In particular, the …
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Lactoferrin in neonatal development: effects on intestinal structure and intestinal function and immune response in a piglet model of systemic Staphylococcus aureus infection
… and formula-fed infants is in part explained by immune factors present in human milk that provide specific and innate immune factors that protect against and directly interact with pathogens (Stuebe 2009). The consumption of human milk also impacts the development of the intestinal microbiota in …