Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Mucosal damage"”.
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Pharmacometric modeling and simulation of ranitidine In human gastric acid secretion.
Stress-related gastric mucosal damage commonly occurs in critically ill patients. Prophylactic therapy has become the standard in patients admitted to intensive care unit to prevent the significant morbidity and mortality associated with acute gastric hemorrhage. Ranitidine has been used widely to …
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Microdialysis to study the Gastrin-ECL cell Axis in the conscious rat
… and limitations of the technique of gastric submucosal microdialysis for the study of ECL-cell histamine mobilization in vivo. We found the microdialysis technique to be a reliable tool for the study of the ECL-cell histamine mobilization in conscious rats. Although there was an inflammatory …
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Effect of Scutellaria Baicalensis on Reduction of Radiation/chemotherapy induced Inflammation
… and radiation therapy for cancer. Mechanism of mucosal damage from both chemotherapy and radiotherapy are thought to be an inflammatory process. It has been known that many herbs have anti-inflammatory effect. This study was aimed to evaluate the anti-inflammatory effect of Scutellaria …
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ISOLATION AND CULTURE OF FIBROBLASTS FROM ENDOSCOPIC DUODENAL BIOPSIES OF CELIAC PATIENTS
… partaker in the pathogenesis of the celiac mucosal damage.
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A Chemically Induced Colitis Screen Reveals the Necessity for Membrane Traffic in Intestinal Homeostasis
… coding/splicing mutations. We induced mild mucosal damage in these mice by orally administering dextran sodium sulfate (DSS) and found mutations that led to diarrhea and weight loss under these conditions. Causative mutations were mapped concurrently with screening using an automated mapping …
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Protective Mechanism of Epigallocatechin-3-gallate against Helicobacter pylori- induced Gastric Epithelial Cytotoxicity via Blockage of TLR-4 Signaling
Helicobacter pylori infection leads to gastric mucosal damage by several mechanisms including the direct effect of virulence factors produced by H. pylori, propagation of inflammation, oxidative stress, DNA damage, and induction of apoptosis. (-)-Epigallocatechin-3-gallate (EGCG), one of green tea …
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Apoptosis in the equine small intestine following experimental ischemia-reperfusion injury
… response. It was designed to determine if mucosal epithelial cells undergo apoptosis during the ischemia phase and also examined if apoptosis is significantly exacerbated by reperfusion. It also investigated whether administration of enalaprilat decreased reperfusion injury secondary to …
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Repair and restitution in the gastrointestinal tract after exposure to a cancer chemotherapy drug.
… was modulated through bioactive factors from mucosal mast cells and cyclooxygenase 2. Sub-epithelial myofibroblast function was also modified, possibly via angiotensin II. Pre-treatment of rats with lectin ameliorated the effects of 5-fluorouracil on the gut. This was due to a novel protective …
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Butyrophilin family genes as putative coeliac disease risk loci
… in intraepithelial lymphocytes (IELs), and mucosal damage, leading to symptoms such as villous atrophy, abdominal pain, malabsorption and malnutrition (5). Currently, the only treatment for CeD is following a gluten-free diet (6). The genetic risk for CeD is not fully understood, as around …
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Nasal delivery of peptides using powder carriers based on starch/poly(acrylic acid)
… with a disruption of the integrity of the mucosal epithelium, in Chapter 4.2 it was investigated if the enhanced nasal bioavailability of insulin after administration of the powder formulation containing (SD 25/75)/CaCO3 90/10 was due to mucosal damage. The possible toxicological effects …