Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Mucosal Immunity"”.
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Systems analysis and characterization of mucosal immunity
… to detrimental disease. Mechanisms underlying immunity to bacterial stimuli span several spatiotemporal magnitudes and the summation of these hierarchical interactions plays a decisive role in pathogenic versus tolerogenic fate for the host. This dissertation integrates diverse data from …
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Interactions Between Gut Microbial Composition, Mucosal Immunity and Metabolism
… affects the microbial ecosystem, intestinal immunity and serum metabolic profiles in C57BL/6 mice. Vancomycin treatment significantly altered gut microbiome composition, affected T cell and innate-like lymphocyte (ILC) populations in the small intestine, and increased levels of intestinal and …
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Characterization of Regulatory Mechanisms in Mucosal Immunity by Systems Immunology
The mucosal immunity of the gastrointestinal (GI) tract is constituted by a complex, highly specialized and dynamic system of immune components that aim to protect the gut from external threats. The sustained exposure of the mucosal immune system of the GI tract to an enormous number of lumen …
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Strategies for the induction of mucosal immunity against hepatitis B virus.
… (ID) injection) and induce systemic but rarely mucosal immunity. Novel vaccination strategies capable of inducing both systemic and mucosal immune responses could greatly reduce infection and morbidity. One such strategy is DNA vaccination whereby the antigen is synthesized in vivo after direct …
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Role of the colonic lymphoglandular complex in mucosal immunity in swine
<p>Colonic lymphoglandular complexes (LGCs) and intestinal mucosa of conventional postweaning pigs were analyzed by flow cytometry and immunohistochemistry using monoclonal antibodies specific for B and T lymphocyte subsets. Lymphocytes were compartmentalized into B (T-independent) and T-dependent …
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Decoding mucosal immunity: Impact of SARS-CoV-2 and Bordetella pertussis vaccination and infection
Contains fulltext : 319744.pdf (Publisher’s version ) (Open Access)
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Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract
… have recently been implicated in regulating gut mucosal immunity during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly. Depletion of Th17 cells from the gut mucosa during HIV infection has been suggested to contribute to elevated microbial …
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ON THE NOSE: MUCOSAL IMMUNE RESPONSES DURING EQUINE HERPESVIRUS TYPE 1 INFECTION
The mucosal immune system is the first line of defense for a broad range of pathogens that greatly impact humans and veterinary species. The respiratory tract is the entry site of many high morbidity and mortality animal viruses, including equine herpesvirus type 1 (EHV-1). EHV-1 is endemic in …
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Modulation of Immune Responses Induced by Vaccination Against Bovine Respiratory Syncytial Virus
… would result in the induction of protective immunity against RSV without risk of deleterious effects. We observed in calves that parenterally delivered FI-bovine RSV (BRSV) formulated with CpG ODN resulted in a shift towards a Th1-biased or more balanced immune response that was protective …
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Interaction between stress and immunity during a week leading to competition in young athletes
… that in the absence of high cortisol levels mucosal immunity is unaffected in young athletes prior to competition.
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The Modulation Of Mucosal Immune Markers, Urs, And Psychological Parameters Following Acute And Chronic Exercise
… provide meaningful contributions to the field of mucosal immune research indicating that a 12 week yoga exercise class may decrease symptomatology of URS. The chronic SIgA secretion increases were attributed to SFR increases and the significant SFR increases may be a benefit for people suffering …
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Immune Dysfunction in Cystic Fibrosis
… that CF patients may have defects in their mucosal immunity, resulting in a predisposition to infection and production of a disproportionate inflammatory response to microbial stimuli. Studies show increased cytokine expression in sputum and bronchoalveolar lavage fluid samples in CF …
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Infekuotų Streptococcus pneumoniae vaikų serologinių ir imunologinių parametrų tyrimai /
… 3, and 18C. Frequently S.pneumonine colonizes mucosal epithelium at nasopharynx without causing any symptoms. In that case the immunity of an organism is of great significance. The second aim of this study is to evaluate the immune response to pneumococcal infection. The amount of separate …
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Characterization of Alpha-Galactosylceramide As A Mucosal Adjuvant
… for immunizations targeting the tolerogenic mucosal tissues, which are more biologically relevant for protective immunity against pathogens transmitted by the mucosal routes. Adjuvants possess the inherent capacity to bridge innate and adaptive immune responses through activating innate …
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Structural studies of the human polymeric immunoglobulin receptor
… epithelial cells. pIgR plays a key role in mucosal immunity and, together with bound immunoglobulins (Igs), provides a first line of specific defense against pathogens and their toxins. pIgR binds dimeric IgA (dIgA) and pentameric IgM (pIgM) produced by local plasma cells and transports …
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The effects of topical calcipotriol treatment on immune responses to vaccination
… vitamin D has been shown to promote mucosal immunity when used as a vaccine adjuvant. We show here that pretreatment of an area of skin with the synthetic vitamin D analog calcipotriol combined with transcutaneous immunization results in the induction of CD4⁺CD25⁺ Tregs capable of …
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INKT CELLS CONTRIBUTE TO COLORECTAL CANCER PROGRESSION INDUCING NEUTROPHILS PRO-TUMORIGENIC FUNCTIONS
… colitis-associated CRC, equally hyporesponsive immunity can promote disease progression, while anti-tumorigenic immunity efficiently limits tumor growth. Mucosal immunity is involved in the patrolling of intestinal tissues and in the maintenance of homeostasis. Disruption of intestinal …
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Mucosal and systemic immune responses induced by immunisation of cotton rats with recombinant adenoviruses
… adenoviruses to elicit gD-specific systemic and mucosal immunity and confer protection against BHV-1 challenge. Immunisation with gD-expressing vectors induced better immunity and protection than immunisation with tgD-expressing viruses. Mucosal immunisation with the replication-competent virus …
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Metabolomic analysis of the interleukin-10-deficient mouse model of Crohn's disease
… arising from the dysregulation of intestinal mucosal immunity. The interleukin-10-deficient (IL10-/-) mouse develops intestinal inflammation with similar characteristics to Crohn’s disease, due to the loss of immune tolerance towards intestinal microbiota. Metabolomic analysis is the study of …
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Functional Characterization of the Avian Inflammatory Mediators Nod1, MIF and IL-22
… the role of these inflammatory mediators in mucosal immunity.
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