Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 492 for “"Mucosal"”.
-
A microfluidic mucosal airway model to study airway mucosal function and pathogenesis
Airway mucus hypersecretion or impaired clearance is one of the key pathophysiological features of airborne infection, allergy and severe respiratory diseases. As foreign particles enter the lungs, the airway becomes inflamed and excessive amount of mucus is generated in response. However, little …
-
Regulation of duodenal mucosal bicarbonate secretion
The present research studied the regulation of duodenal bicarbonate secretion in the anaesthetized guinea-pig, using a model that permitted the study of active transport of bicarbonate. It was determined that dibutyryl 3' ,5'-cyclic adenosine monophosphate, vasoactive intestinal polypeptide, …
-
Mucosal Immunopathogenesis of Feline Immunodeficiency Virus (FIV)
… model of HIV immune dysfunction but the mucosal pathogenesis of FIV infection has not been well studied. In the present study, we (1) identify the normal phenotype of feline small intestinal leukocyte populations; (2) characterize changes occurring in the gastrointestinal immune system of …
-
The mucosal microbiome of inflammatory bowel diseases
… other cutting edge techniques to elucidate the mucosal associated microbiome in Inflammatory Bowel Disease and finally examines the viability of using mucosal samples for shotgun metagenomics or metatranscriptomics. Taxonomic classification is a corner stone for the characterisation of microbial …
-
Mucosal HIV-1 Transmission in Humanized Mice
… and safety testing. Given the importance of mucosal HIV-1 transmission, the susceptibility of humanized mice to intrarectal and intravaginal HIV-1 infection was investigated. Human lymphocytes, including CD4+ T cells, generated in situ from hematopoietic stem cells reconstitute the …
-
Development of a mucosal vaccine delivery system
Vaccine delivery systems that target the mucosal immune system carry important advantages in terms of accessibility and acceptability. Lipid based nanoparticles with and without the incorporation of bile salts were formulated by novel preparation methods in order to provide suitable immunogen …
-
Systems analysis and characterization of mucosal immunity
… driven by computational modeling to study mucosal immunity. Two contrasting microbes, enteroaggregative Escherichia coli and Helicobacter pylori, are used to perturb gut immunity in order to discover host-centric targets for modulating the host immune system. These findings have the …
-
Characterization of Alpha-Galactosylceramide As A Mucosal Adjuvant
… for immunizations targeting the tolerogenic mucosal tissues, which are more biologically relevant for protective immunity against pathogens transmitted by the mucosal routes. Adjuvants possess the inherent capacity to bridge innate and adaptive immune responses through activating innate …
-
Mucin and mucin glycans alter behaviorof mucosal pathogens
The majority of the microorganisms that colonize the human body, collectively the human microbiota, reside within the mucus layer. While mucus hydrates and lubricates host tissues, it also serves as a protective barrier. Mucus physically blocks pathogens and other microorganisms from reaching host …
-
Interactions Between Gut Microbial Composition, Mucosal Immunity and Metabolism
While evidence that the intestinal microbiome contributes to host health and disease has rapidly developed, the causal mechanisms that link these microbes to disease are largely elusive. The goal of this project was to explore the complex crosstalk between the microbiome and the immune system using …
-
An investigation of novel biomarkers of gastric mucosal preneoplasia
… have described the role of various gastric mucosal proteins in carcinogenesis following H. pylori infection. We hypothesised that these proteins might be upregulated in gastric preneoplasia and might in turn be used as biomarkers of the same. We recruited patients attending hospital for …
-
Mucosal Barrier Injury, Innate Immunity, and Stem Cell Transplantation
Contains fulltext : 87189.pdf (Publisher’s version ) (Open Access)
-
Optimisation and validation of an alternative mucosal irritation test
… met de mucosa in contact komen na te gaan of ze mucosale irritatie en beschadiging veroorzaken. De regelgevende instanties vereisen over het algemeen dat de lokale tolerantie van producten in vertebraten wordt beoordeeld. Het gebruik van vertebraten voor veiligheidstests wordt echter sterk in …
-
Characterization of mucosal dysplasia with ultraviolet resonance Raman spectroscopy
Thesis (Ph. D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 1997.
-
Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action
Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis spans several areas that are important for future development of mucosal …
-
The Role of Mucosal Epithelial Cells In Hiv-1 Infection
… pathogens, are the first cell type at these mucosal tissues to encounter the virus but their role in HIV infection has not been clearly elucidated. Although mucosal epithelial cells express only low levels of the receptors required for successful HIV infection, productive infection does occur …
-
Regulation of macrophage subsets in homeostatic and inflammatory mucosal environments
… epithelial cells and macrophages is integral to mucosal immune fate: determining the decision between tolerance and immune activation/inflammation. Endotoxin tolerisation (ET) is a circumstance where cells go through a hypo-responsive state, unable to respond to further endotoxin-LPS challenge. …
Page 1 of 25