Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Mucociliary Clearance"”.
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Nebulized Hypertonic Saline-Triggered Increase in Mucociliary Clearance Rate is Mediated by the Nervous System
… into the airway lumen and, thus, increasing mucociliary clearance (MCC). However, recent research has also demonstrated that HTS-triggered increase in ASL height is mediated by the nervous system, whereby HTS stimulates sensory neurons to promote active secretion of ASL via airway epithelia. …
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The Role of Hydrocortisone on the Development and Maintenance of Ion Transport Pathways Essential to Mucociliary Clearance in Differentiated Normal Human Bronchial Epithelial Cells
… pathogens from the lungs by a process known as mucociliary clearance. Current treatment strategies for patients with asthma, COPD and other inflammatory airway disorders emphasize a combined therapy involving inhaled corticosteroid (ICS) and long-acting β2-agonists (LABA) aimed at reducing …
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The biochemical characterisation of respiratory mucus & mucins in normal, asthma & COPD
… enable it to be transported out of the lungs by mucociliary clearance.
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Channel activating proteases: molecular targets for correction of sodium channel dysfunction in cystic fibrosis airways disease
… airways dehydration, thickened mucus, impaired mucociliary clearance and is thought to be a major contributor to the pathogenesis of lung disease. Previous work has shown that QUB-TL1, an active site directed inhibitor of trypsin and trypsin-like enzymes, reduces ENaC-mediated sodium absorption …
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Regulation of airway epithelial cell migration by the cystic fibrosis transmembrane conductance regulator.
… particles in inspired air and the lung tissue. Mucociliary clearance is an essential function of the airway epithelium to protect against infection and airway damage. By this process, inhaled particles are trapped in the mucus lining the airway and propelled out of the airways by ciliary …
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Cirrhosis-Induced Defects in Innate Puemonary Defenses Against Streptococcus Pneumoniae
… defenses analyzed within this research included mucociliary clearance, early pre-neutrophil- and later neutrophil-mediated defenses, and in vivo complement deposition inside the lungs. Cirrhosis was induced in male Sprague-Dawley rats by weekly gavage with carbon tetrachloride, whereas control …
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Primary Ciliary Dyskinesia: An Epidemiological Exploration. Furthering our understanding of the burden of disease in PCD
… by dysfunctional motile cilia and abnormal mucociliary clearance. In recent years, there have been significant advancements in the understanding of PCD including, but are not limited to, disease frequency estimates in specific ethnic groups and geographical regions, the expansion of …
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Novel endoscopes for microscopic assessment of airway clearance using micro-optical coherence tomography
… respiratory system depends critically on airway clearance via motile hair-like structures (cilia), which transport and eliminate unwanted particles trapped within mucus. Impairment of mucociliary clearance (MCC) can lead to life-threatening airway narrowing and lung infections, and is a major …
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The development of novel strategies to modulate epithelial sodium channel (ENaC) activity in chronic obstructive pulmonary disease (COPD)
Impaired mucociliary clearance (MCC) which leads to infection, inflammation, and progressive lung damage is a hallmark of the chronic bronchitis (CB) phenotype in COPD, and the hydration status of the airways has been indicated as the main factor affecting this disorder. Inhibition of ENaC function …
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Comparison of Potential Salmonella Portals of Entry and Tissue Distribution Following Challenge of Poultry
… oral ingestion, due to the presence of the mucociliary clearance was evaluated. Suspension in 1% mucin failed to increase the infectivity at any dose of Salmonella when compared to OR administration without mucin and intratracheal (IT) challenge, which was also recovered from lung tissue. IT …
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Understanding the Collective Dynamics of Motile Cilia in Human Airways
… and one that is central to this thesis, is mucociliary clearance in human airways: A carpet of motile cilia helps keeping the cell surface free from pathogens and foreign particles by constantly evacuating from lungs, bronchi, and trachea a barrier of mucus. The question of how motile cilia …
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TAp73 regulates mitochondrial dynamics through an OPA1 axis
… defective cilia have a reduced capacity for mucociliary clearance of inhaled toxic particles. Loss of TAp73 function and the concomitant increase in sensitivity to apoptosis may therefore further enhance vulnerability to inhaled pathogens or pollutants, highlighting a possible role for TAp73 …
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An investigation of the cellular effects of novel agents and multi-drug combinations in cystic fibrosis
… fibrosis (CF), airways dehydration and impaired mucociliary clearance (MCC) is due to a lack of cystic fibrosis transmembrane conductance regulator (CFTR) chloride secretion and overactive epithelial sodium channels (ENaC), which leads to hyper-absorption of Na+ and water from the airway lumen. …
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INVESTING THE ROLES OF E26 TRANSFORMATION-SPECIFIC HOMOLOGOUS FACTOR IN CYSTIC FIBROSIS LUNG DISEASE
… disease (CFLD) where CF airways have impaired mucociliary clearance and undergo constant remodelling and chronic inflammation, ultimately leading to irreversible loss of lung function. Interestingly, within CF patients carrying the same CFTR mutation resides a high variability in terms of CFLD …
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Exploring Ciliary Dynamics: Assessing Motility and Induced Velocity in Human Airway Cell Cultures
The human respiratory tract going from the nose to the terminal bronchioles is lined by a mucociliated epithelium. Here, cilia underpin an essential defence mechanism known as MCC. This process clears inhaled pathogens and contaminants from the airways and exhibits various degrees of complexity. …
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LIPID-BASED APPROACHES TO OPTIMIZE THE EFFECTIVENESS OF INNOVATIVE DRUG MODULATORS IN CYSTIC FIBROSIS
… primarily the respiratory system, with impaired mucociliary clearance and airway surface liquid dehydration, leading to recurrent infections and high morbidity. The most common mutation, the deletion of phenylalanine at position 508 (F508del), induces misfolding and retention of CFTR in the …
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Understanding and predicting pulmonary exacerbations in Cystic Fibrosis using Machine Learning
… and viscous outer mucous layer, and impaired mucociliary clearance. This in turn leads to airway obstruction and chronic bacterial infection. Recurring, sudden, clinical deteriorations in respiratory symptoms - termed acute pulmonary exacerbations (APEs) - cause cumulative damage to the lungs, …
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Der Einfluss der Therapie mit Dornase alfa auf Beatmungsdauer und Entzündungsmediatoren bei beatmeten neurologischen Patienten
Nosokomiale Pneumonie stellt laut aktuellen Ergebnissen des Krankenhaus-Infektions-Surveillance-Systems (KISS) die häufigste Hospitalinfektion dar. Bei einem über 48 Std. beatmeten Patienten liegt die Inzidenz einer nosokomialen Pneumonie zwischen 10-20 %. Die neurologischen Patienten nehmen eine …