Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Mucoadhesion"”.
-
Development of novel formulations for mucosal delivery of protein based drugs
… 2% mucin concentration was found optimum for mucoadhesion studies of the chitosan based xerogels. EI (glutathione; GSH and aprotinin; APR) effect on mucoadhesion was concentration dependent and inhibitor specific. In vitro BSA release profiles from annealed xerogels were similar and …
-
Elucidating bioadhesive processes in nasal drug delivery systems
… viscosity. Thixotropy, a vital property in mucoadhesion, was also assessed. The greatest thixotropy was found with polymers of increasing molecular weight whereas low molecular weight polymers exhibited little or no thixotropy. As expected, high molecular weight polymers produced strongly …
-
Formulation of novel buccal mucosal drug delivery systems for nicotine replacement therapy (NRT)
… using texture analyser (TA) (mechanical and mucoadhesion properties), scanning electron microscopy (SEM) (surface and internal morphology), X-ray diffractometry (XRD) (physical form), attenuated total reflectance – Fourier transform infrared (ATR-FTIR) spectroscopy (physical interactions), …
-
Development and characterisation of medicated wound dressings for chronic wound healing
… films and wafers were analysed for swelling, mucoadhesion (in presence of normal and viscous simulated wound fluid), in vitro drug dissolution and anti-bacterial activity and compared against marketed medicated wound dressings. Addition of drug (STP and DLF) resulted in fair transparency of …
-
A Novel IN SITU Gel for Sustained Drug Delivery and Targeting
… and mucin type III as the substrate for mucoadhesion. Combination of chitosan and GMO, showed a 3-7 fold increase in the mucoadhesion. In conclusion, the novel chitosan-GMO delivery system can be used both for oral and parenteral drug delivery to sustain the release of both hydrophilic …
-
The physico-chemical and biological analysis of microbial biosurfactants (BSs) for applications towards cancer therapies, wound healing dressings and drug delivery
… characterised for hardness, ATR-FTIR, XRD, mucoadhesion and exudate handling properties. Anticancer activity was successfully detected and compared in all BSs selected for investigation in cancerous cells, additionally, all BSs had higher selectivity index than doxorubicin (DOX) and …
-
Formulation of Hyaluronidase Enzyme Sensitive Topical Nanomicrobicides for HIV Virus Transmission Prevention
… morphology, surface chemistry, crystallinity, mucoadhesion property, and in vitro drug release profile using size exclusion chromatography, powder X-ray diffraction, FT-IR, and ¹H-NMR analyses. Mucin interaction and ellipsometer measurements confirmed that mucoadhesion of HA-SH-NFs was …
-
Formulation and characterisation of novel films for buccal mucosa drug delivery for paediatric patients
… Results obtained for the hydration and in vitro mucoadhesion studies showed that plasticised films had higher swelling capacity and mucoadhesivity than unplasticised films. In addition, BLK films showed higher swelling index and adhesion than DL films, whilst gelatine equilibrated with PBS showed …
-
Towards a more efficacious treatment for Oropharyngeal Candidiasis (OPC): Hydrogel-forming tablets for the controlled release delivery of Chlorhexidine diacetate
… for their physical properties, ex vivo mucoadhesion, the rate of hydration, gelling efficiency using image analysis, differential scanning calorimetry (DSC), Fourier transforms infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and in vitro dissolution using Apparatus I and a novel …
-
Development and Evaluation Of HIV gp120 Responsive Microbicide Formulation for the Prevention of HIV Sexual Transmission
… drug release studies as well as ex vivo vaginal mucoadhesion studies. HIV gp120 triggered TFV release from 𝐶+𝑀𝑅𝑃 in a concentration dependent manner, and following Hixson–Crowell and Hopfenberg kinetic models, consistent with drug release from diminishing surface or matrix eroding drug particles. …
-
Novel polyelectrolyte complexes for oral insulin delivery.
Oral delivery of insulin used for the management of Type 1 diabetes could be referred to as one of the major long-term goals of diabetes research. However, the bioavailability of orally-administrered insulin is significantly compromised by enzymatic degradation in the GI tract, and poor enteral …
-
Chitosan and PLGA microspheres as drug delivery system against pulmonary mycobacteria infections
Various types of rifampicin (RIF)-loaded microparticles were compared for their stability during nebulization. Poly(lactide-co-glycolide) (PLGA), chitosan (CHT) and PLGA/CHT microparticles (MPs) were prepared by emulsion, precipitation or spray-drying techniques. MPs ability to be nebulized (NE%) …