Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Mucin-1"”.
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Cancer immunotherapy with Mucin-1 and cytokines
Cancer immunotherapy involves the manipulation of the immune response to combat tumour cells. The studies contained within investigated the role of cytokines in the anti-tumour immune response to the cancer antigen, MUCl, which is over produced in an altered form in cancers of the breast, pancreas, …
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Structural study of human antibody fragments with specificity for Mucin-1 antigen
MUC1 is overexpressed in many adenocarcinomas, which makes it a potential target for immunotherapy. A large number of MUC1-specific, monoclonal antibodies have been produced but the stability, solubility and the size of the antibody determines their effectiveness in cancer therapy. Smaller antibody …
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The Biomedical Application of Conducting Polymers for the Electrochemical Detection of Diseases
… molecule adenosine and two cancer-associated mucin 1 polypeptides was developed utilizing a conductive copolymer a transducing agent. First, a method was developed to modify the surface of indium tin oxide slides to enable robust copolymer deposition. The poly(3,4-ethylene dioxythiophene) …
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Protein L Functionalized Microparticles For Early Detection of Surface Markers In Heterogeneous Colorectal Lesions
… Antibody-Protein L functionalized MPs identify Mucin 1 (MUC1) and epithelial cell adhesion molecule EpCAM positive tumoroids proportionally to antigen expression, 2) Antibody-Protein L MPs detect CRC surface antigens on the luminal colon surface in vivo, and 3) concurrent targeting of multiple …
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ROLES OF HAND2 TRANSCRIPTION FACTOR IN UTERINE RECEPTIVITY AND DECIDUALIZATION
… proliferation. The abnormal in expression of Mucin 1, Calcitonin and E-Cadherin in Hand KO uterus may be responsible for defects in the uterine receptivity. The expression of HAND2 was also critical in decidualization in vitro. Silencing and over-expression HAND2 disclosed the roles of HAND2 …
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Influence of infant milk formula processing on protein digestion and gut barrier health in vitro and in vivo
… higher number of goblet cells, acidic mucus and mucin-2 protein in the jejunum compared to pigs fed HT-IMF (P < 0.05). In the duodenum, MEM-IMF fed pigs had higher trypsin activity in the gut lumen, higher mRNA transcript levels of claudin-1 in the mucosal scrapings and higher lactase activity in …
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Unnatural glycopeptides with application on cancer research
… relevant implications to fight against cancer: mucins, such as mucin-1 (MUC1), and antifreeze glycoproteins. Concerning the first mentioned class, mucins are a family of O-glycoproteins with high molecular weight that serve as cell-surface receptors and sensors. Notably, aberration in the …
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A two-pronged approach towards the development of novel therapeutics for advanced endometrial cancer
… of the mechanism and physiological effect of mucin 1 (MUC1)-driven epidermal growth factor receptor (EGFR) expression and signaling. MUC1 is a large, heavily glycosylated transmembrane protein that functions to lubricate surfaces, provides protection from external insult and plays an important …
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MUCIN-MEDIATED AND INTERFERON-DRIVEN DEFENSE MECHANISMS AGAINST INFLUENZA VIRUS INFECTION IN HUMAN AIRWAY EPITHELIUM
… predominantly of individual proteins termed mucins. Additionally, underlying epithelial cells produce interferons upon virus detection that promote the establishment of a local antiviral state through autocrine and paracrine signaling. However, despite these protective measures, IAV continues …
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In silico redesign and de novo design of anti-MUC1 monoclonal antibodies
Mucin 1 (MUC1) is a cellular membrane-tethered protein which is abnormally glycosylated and overexpressed in several epithelial cancers. This abnormal glycosylation is hypothesized to participate in the hyper-activation of signaling pathways which promote tumor growth and provides a suitable target …
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MiR-145 is a tumor suppressor in both tumor progression and metastasis
… part due to the silencing of the metastasis gene mucin 1 (MUC1). Using luciferase reporters carrying the 3′-untranslated region of MUC1 combined with Western blot and immunofluorescence staining, we identify MUC1 as a direct target of miR-145. Moreover, ectopic expression of MUC1 enhances cell …